Results 41 to 50 of about 21,084,718 (300)

Electrophoretic behavior of mammalian-type cytochromes c.

Journal of Biological Chemistry, 1966
Anomalous boundaries resulting from the binding of a buffer constituent give the appearance of electrophoretic inhomogeneity to pure crystalline native monomeric cytochromes c from 10 species (man, horse, hog, guanaco, Pekin duck, pigeon, turkey, tuna, a
G. Barlow, E. Margoliash
semanticscholar   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Efficient and selective isotopic labeling of hemes to facilitate the study of multiheme proteins

BioTechniques, 2012
Specific isotopic labeling of hemes provides a unique opportunity to characterize the structure and function of heme-proteins. Unfortunately, current methods do not allow efficient labeling in high yields of multiheme cytochromes c, which are of great ...
Bruno M. Fonseca, Ming Tien, Mario Rivera, Liang Shi, Ricardo O. Louro   +4 more
doaj   +1 more source

Iron or sulfur respiration—an adaptive choice determining the fitness of a natronophilic bacterium Dethiobacter alkaliphilus in geochemically contrasting environments

Frontiers in Microbiology, 2023
Haloalkaliphilic microorganisms are double extremophiles functioning optimally at high salinity and pH. Their typical habitats are soda lakes, geologically ancient yet widespread ecosystems supposed to harbor relict microbial communities.
Daria G. Zavarzina, Alexander Yu Merkel, Alexandra A. Klyukina, Ivan M. Elizarov, Valeria A. Pikhtereva, Valeria A. Pikhtereva, Vyacheslav S. Rusakov, Nataliya I. Chistyakova, Rustam H. Ziganshin, Alexey A. Maslov, Sergey N. Gavrilov   +10 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Deep-branching ANME-1c archaea grow at the upper temperature limit of anaerobic oxidation of methane

Frontiers in Microbiology, 2022
In seafloor sediments, the anaerobic oxidation of methane (AOM) consumes most of the methane formed in anoxic layers, preventing this greenhouse gas from reaching the water column and finally the atmosphere.
David Benito Merino, David Benito Merino, Hanna Zehnle, Hanna Zehnle, Hanna Zehnle, Andreas Teske, Gunter Wegener, Gunter Wegener   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The complex of cytochrome c and cytochrome c peroxidase: The end of the road?

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2011
Cytochrome c (Cc) and cytochrome c peroxidase (CcP) form a physiological complex in the inter-membrane space of yeast mitochondria, where CcP reduces hydrogen peroxide to water using the electrons provided by ferrous Cc. The Cc-CcP system has been a popular choice of study of interprotein biological electron transfer (ET) and in understanding dynamics ...
Volkov, A.N., Worrall, J.A.R., Nicholls, P.   +2 more
openaire   +3 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Optimizing Electroactive Organisms: The Effect of Orthologous Proteins

Frontiers in Energy Research, 2019
Extracellular electron transfer pathways allow bacteria to transfer electrons from the cell metabolism to extracellular substrates, such as metal oxides in natural environments and electrodes in microbial electrochemical technologies (MET).
Bruno M. Fonseca, Luís Silva, Inês B. Trindade, Elin Moe, Pedro M. Matias, Pedro M. Matias, Ricardo O. Louro, Catarina M. Paquete   +7 more
doaj   +1 more source