Results 41 to 50 of about 19,718,861 (281)

Amino Acid Substitutions in the Non-Ordered Ω-Loop 70–85 Affect Electron Transfer Function and Secondary Structure of Mitochondrial Cytochrome c

Crystals, 2021
The secondary structure of horse cytochrome c with mutations in the P76GTKMIFA83 site of the Ω-loop, exhibiting reduced efficiency of electron transfer, were studied.
Rita V. Chertkova, Tatyana V. Bryantseva, Nadezhda A. Brazhe, Kseniya S. Kudryashova, Victor V. Revin, Alexei N. Nekrasov, Alexander I. Yusipovich, Alexey R. Brazhe, Andrew B. Rubin, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Georgy V. Maksimov   +11 more
doaj   +1 more source

Cytochromes P460 and c′-beta; A new family of high-spin cytochromes c

, 2007
Cytochromes-P460 of Nitrosomonas europaea and Methylococcus capsulatus (Bath), and the cytochrome c′ of M. capsulatus, believed to be involved in binding or transformation of N-oxides, are shown to represent an evolutionarily related new family of ...
Bradley O. Elmore, Elmore, Bradley O, Klotz, Martin G, Hooper, Alan B, Alan B. Hooper, Martin G. Klotz, David J. Bergmann, Bergmann, David J   +7 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Vibrio natriegens as a superior host for the production of c-type cytochromes and difficult-to-express redox proteins

Scientific Reports
C-type cytochromes fulfil many essential roles in both aerobic and anaerobic respiration. Their characterization requires large quantities of protein which can be obtained through heterologous production.
Helena Fuchs, Sophie R. Ullrich, Sabrina Hedrich   +2 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

The structure of protozoan cytochromes [PDF]

, 1974
C-type cytochromes from two protozoa, Crithidia oncopelti and Kuglena gracilis. were purified and partly characterised. Crithidia cytochrome C557 and Euglena cytochrome C558 had certain atypical spectral characteristics. The sequence of amino acids in
Pettigrew, Graham Walter
core   +3 more sources

Aspongopus chinensis-derived cytochrome c delivered via lentivirus-like particles induces mitochondrial apoptosis to inhibit HER2-positive breast cancer

陆军军医大学学报
Objective Human epidermal growth factor receptor 2 (HER2)-positive breast cancer accounts for approximately 20% of all breast cancer cases. Persistent activation of the HER2/PI3K/AKT signaling pathway enables tumor cells to evade mitochondrial apoptosis
Li Xiping, Li Xiping, Wang Min, Peng Li   +3 more
doaj   +1 more source

Efficient and selective isotopic labeling of hemes to facilitate the study of multiheme proteins

BioTechniques, 2012
Specific isotopic labeling of hemes provides a unique opportunity to characterize the structure and function of heme-proteins. Unfortunately, current methods do not allow efficient labeling in high yields of multiheme cytochromes c, which are of great ...
Bruno M. Fonseca, Ming Tien, Mario Rivera, Liang Shi, Ricardo O. Louro   +4 more
doaj   +1 more source

Iron or sulfur respiration—an adaptive choice determining the fitness of a natronophilic bacterium Dethiobacter alkaliphilus in geochemically contrasting environments

Frontiers in Microbiology, 2023
Haloalkaliphilic microorganisms are double extremophiles functioning optimally at high salinity and pH. Their typical habitats are soda lakes, geologically ancient yet widespread ecosystems supposed to harbor relict microbial communities.
Daria G. Zavarzina, Alexander Yu Merkel, Alexandra A. Klyukina, Ivan M. Elizarov, Valeria A. Pikhtereva, Valeria A. Pikhtereva, Vyacheslav S. Rusakov, Nataliya I. Chistyakova, Rustam H. Ziganshin, Alexey A. Maslov, Sergey N. Gavrilov   +10 more
doaj   +1 more source