Results 121 to 130 of about 22,374,088 (435)

Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia. [PDF]

, 2019
Dasatinib, a second-generation BCR-ABL1 tyrosine kinase inhibitor, is approved for the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, both as first-line therapy and after imatinib intolerance or ...
Abruzzese, Elisabetta, Cortes, Jorge E, Hochhaus, Andreas, Hughes, Timothy P, Laneuville, Pierre, Lipton, Jeffrey H, Paar, David, Rea, Delphine, Rousselot, Philippe, Shah, Neil P, Snyder, David S   +10 more
core   +2 more sources

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source

Medical Implementation of Microarray Technology

Korean Journal of Clinical Laboratory Science, 2020
Microarray technology represents a critical new advance in molecular cytogenetics. The de-velopment of this approach has provided fundamental insights into the molecular pathogenesis in clinical cytogenetics and has provided a clue to many unidentified ...
Ji Un Kang
doaj   +1 more source

Kanserli hücre hatları, pasaj sayısı arttıkça genomik organizasyonunu ve karyotipini değiştirir: sitogenetik bir çalışma

Cukurova Medical Journal, 2018
Amaç: İnsan sağlığına ilişkin bilimsel araştırmalarda memelilerin sınırlı kullanımı yeni araştırma stratejilerinin geliştirilmesine yol açmıştır. Bunlardan birisi memeli hücre kültürü tekniğidir.
M. Bertan YILMAZ, Erdal TUNÇ, N. Seda ILGAZ, Hale ÖKSÜZ, Ezgi ÖZTECİK, Lütfiye ÖZPAK, İşıl ÖCAL, Ayfer PAZARBAŞI, Osman DEMİRHAN   +8 more
doaj   +1 more source

A comparative cytogenetic analysis of 2 Bothriuridae species and overview of the chromosome data of Scorpiones.

Journal of Heredity, 2009
The order Scorpiones is one of the most cytogenetically interesting groups within Arachnida by virtue of the combination of chromosome singularities found in the 59 species analyzed so far.
M. C. Schneider, A. A. Zacaro, R. Pinto‐da‐Rocha, D. Cândido, D. Cella   +4 more
semanticscholar   +1 more source

BCR::ABL1‐Positive Acute Myeloid Leukemia

American Journal of Hematology, EarlyView.
Alban Canali, Jean‐Baptiste Rieu, Leopoldine Lapierre, Barbara J. Bain   +3 more
wiley   +1 more source

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp, Elizabeth A. VanSickle, Julianne Michael, Chad R. Schultz, Kelly Nguyen, Melissa Hoefer, Surender Rajasekaran, André S. Bachmann   +7 more
wiley   +1 more source

Exploring the Effects of Robertsonian Translocation 1/29 (Rob (1;29)) on Genetic Diversity in Minor Breeds of Spanish Berrenda Cattle via Genome-Wide Analysis

Animals
Most of the previous studies on the genetic variability in Spanish “Berrenda” breeds have been carried out using DNA microsatellites. The present work aimed to estimate the genetic diversity, population structure, and potential genetic differences among ...
Rafael González-Cano, Ana González-Martínez, Manuel Ramón, Miriam González Serrano, Miguel Moreno Millán, Alejandro Rubio de Juan, Evangelina Rodero Serrano   +6 more
doaj   +1 more source

Molecular markers and cytogenetics of Eleven O’Clock Portulaca umbraticola: a non-conventional edible ornamental crop [PDF]

Brazilian Journal of Biology
Portulaca umbraticola, commonly known as “Eleven o'clock”, is a popular ornamental plant in Brazil, but its potential as a non-conventional food source remains underexplored.
J. S. Souza, C. C. C. G. Nunes, M. M. Rêgo, A. M. S. Santos, C. A. P. S. Rodrigues, S. H. Unêda-Trevisoli, E. R. Rêgo   +6 more
doaj   +1 more source

The Karyotype Ontology: a computational representation for human cytogenetic patterns [PDF]

arXiv, 2013
The karyotype ontology describes the human chromosome complement as determined cytogenetically, and is designed as an initial step toward the goal of replacing the current system which is based on semantically meaningful strings. This ontology uses a novel, semi-programmatic methodology based around the tawny library to construct many classes rapidly ...
arxiv