A Network‐Driven Framework for Drug Response Precision Prediction of Acute Myeloid Leukemia
Advanced Science, EarlyView.A network‐based precision medicine platform, named NetAML is offered for personalized treatment of AML. It combines network analysis and machine learning to develop 87 models predicting drug sensitivity for clinical drugs. NetAML identifies interpretable gene signatures that drive differential drug responses, enabling the prediction of individual ...
Yinyin Wang +7 more
wiley +1 more source
Hereditary multiple exostoses caused by a chromosomal inversion removing part of EXT1 gene
Molecular Cytogenetics, 2023 Background Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder characterized by the development of multiple, circumscript and usually symmetric bony protuberances called osteochondromas.
Angelos Alexandrou +10 more
doaj +1 more source
Metaphase and Interphase Cytogenetics with Alu-PCR-amplified Yeast Artificial Chromosome Clones Containing the BCR Gene and the Protooncogenes c-raf-1, c-fms, and c-erbB-21 [PDF]
, 1992 A human yeast artificial chromosome (YAC) library was screened by polymerase chain reaction with oligonucleotide primers defined for DNA sequences of the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erB-2.
Becher, Reinhard +8 more
core
Molecular cytogenetic differentiation of paralogs of Hox paralogs in duplicated and re-diploidized genome of the North American paddlefish (Polyodon spathula). [PDF]
, 2017 BackgroundAcipenseriformes is a basal lineage of ray-finned fishes and comprise 27 extant species of sturgeons and paddlefishes. They are characterized by several specific genomic features as broad ploidy variation, high chromosome numbers, presence of ...
Amemiya, Chris T +7 more
core +4 more sources
Cytogenetics of hepatoblastoma
Frontiers in Bioscience, 2012 The cytogenetics of hepatoblastoma demonstrate recurring events which include whole chromosome trisomies, most commonly trisomy of chromosome 2, 8, or 10. In addition, unbalanced translocations involving a breakpoint on the proximal short arm of chromosome 1 are observed which result in a duplication of the long arm of chromosome 1q.
openaire +3 more sources
Advanced Science, EarlyView.High‐resolution spatiotemporal transcriptomic data from male and female spinach inflorescences across four key stages first reveal the sex differentiation initiates at the four‐leaf stage and is governed by epigenetic regulation via the SpMSI1‐SpHDT2 complex.
Chen You +10 more
wiley +1 more source
Candidate genes for infertility: an in-silico study based on cytogenetic analysis
BMC Medical Genomics, 2022 Background The cause of infertility remains unclear in a significant proportion of reproductive-age couples who fail to conceive naturally. Chromosomal aberrations have been identified as one of the main genetic causes of male and female infertility ...
Jatinder Singh Sahota +3 more
doaj +1 more source
Genetic analysis of products of conception. Should we abandon classic karyotyping methodology?
Einstein (São Paulo), 2021 Objective: To compare the results obtained by the classic and molecular methodology in the analysis of products of conception, the advantages and disadvantages of each method.
Denise Maria Christofolini +5 more
doaj +2 more sources
Chromosomal in situ suppression hybridization of human gonosomes and autosomes and its use in clinical cytogenetics [PDF]
, 1990 DNA libraries from sorted human gonosomes were used selectively to stain the X and Y chromosomes in normal and aberrant cultured human cells by chromosomal in situ suppression (CISS-) hybridization.
Cremer, Thomas +5 more
core +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov +2 more
wiley +1 more source