Results 51 to 60 of about 132,265 (338)

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease [PDF]

, 2014
© 2014 John Wiley & Sons Ltd. Defining the prognosis of individual cancer sufferers remains a significant clinical challenge. Here we assessed the ability of high-resolution single telomere length analysis (STELA), combined with an experimentally ...
Allan, James M., Allsup, David J., Bailey, James, Baird, Duncan M., Britt-Compton, Bethan, Cawkwell, Lynn, Fegan, Chris, Grimstead, Julia W., Heppel, Nicole H., Hills, Robert, Jones, Rhiannon E., Lin, Thet Thet, Norris, Kevin, Pepper, Chris, Pratt, Guy   +14 more
core   +1 more source

RanBALL: An Ensemble Machine Learning Framework for Accurate Subtype Identification of Pediatric B‐Cell Acute Lymphoblastic Leukemia

Advanced Intelligent Systems, EarlyView.
Here, we present RanBALL, an ensemble random projection‐based model for accurate and cost‐effective identification of B‐cell acute lymphoblastic leukemia subtypes is presented. By preserving patient‐to‐patient distance after dimension reduction by random projection and ensemble learning, RanBALL can facilitate the discovery of B‐ALL subtype‐specific ...
Lusheng Li, Hanyu Xiao, Xinchao Wu, Zhenya Tang, Joseph D. Khoury, Jieqiong Wang, Shibiao Wan   +6 more
wiley   +1 more source

Post-cancer Treatment with Condurango 30C Shows Amelioration of Benzo[a]pyrene-induced Lung Cancer in Rats Through the Molecular Pathway of Caspa- se-3-mediated Apoptosis Induction

Journal of Pharmacopuncture, 2013
Objectives: The present investigation aimed at examining if post-cancer treatment with a potentized homeopathic drug, Condurango 30C, which is generally used to treat oesophageal cancer, could also show an ameliorating effect through apoptosis induction ...
Sikdar Sourav , Mukherjee Avinaba , Bishayee Kausik , Paul Avijit , Saha Santu Kumar , Ghosh Samrat , Khuda-Bukhsh Anisur Rahman   +6 more
doaj   +1 more source

Extramedullary Disease—Achilles Heel in Myeloma?

American Journal of Hematology, EarlyView.
ABSTRACT Despite advances in therapy, extramedullary disease (EMD) remains an aggressive form of multiple myeloma associated with poor outcomes. Patients with true EMD, in which plasmacytomas have become completely independent of bone, have a particularly poor prognosis. The pathogenesis of EMD is driven by complex mechanisms involving loss of adhesion
Shaji Kumar, Joshua Richter, Saad Z. Usmani, Yael C. Cohen, Jing Christine Ye, María‐Victoria Mateos, Vania Hungria, Elena Zamagni   +7 more
wiley   +1 more source

IMPACT OF HIGH-RISK CYTOGENETICS ON THE SURVIVAL OF NON-APL ACUTE MYELOID LEUKEMIA PATIENTS

Hematology, Transfusion and Cell Therapy
Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the rapid proliferation of abnormal myeloid cells in the bone marrow and peripheral blood.
FMCP Pessoa, DS Oliveira, IV Barreto, AKC Machado, BMD Nogueira, CB Machado, RM Ribeiro, MOM Filho, MEA Moraes, CA Moreira-Nunes   +9 more
doaj   +1 more source

23rd International Colloquium on Animal Cytogenetics and Genomics (23 ICACG) June 9–12, 2018, Saint-Petersburg, Russia

Comparative Cytogenetics, 2018
In memory of Ingemar Gustavsson 23rd International Colloquium on Animal Cytogenetics and Genomics (23 ICACG) took place in June 9–12, 2018 in Saint-Petersburg, Russia. Organized biennially, the Colloquium runs from 1970.
Svetlana Galkina, Maria Vishnevskaya
doaj   +3 more sources

Genetic and linguistic non-correspondence suggests evidence for collective social climbing in the Kol tribe of South Asia

Scientific Reports, 2020
Both classical and recent genetic studies have unanimously concluded that the genetic landscape of South Asia is unique. At long distances the ‘isolation-by-distance’ model appears to correspond well with the genetic data, whereas at short distances ...
Anshika Srivastava, Prajjval Pratap Singh, Audditiya Bandopadhyay, Pooja Singh, Debashruti Das, Rakesh Tamang, Akhilesh Kumar Chaubey, Pankaj Shrivastava, George van Driem, Gyaneshwer Chaubey   +9 more
doaj   +1 more source

Polyploid races, genetic structure and morphological features of earthworm Aporrectodea rosea (Savigny, 1826) (Oligohaeta: Lumbricidae) in Ukraine [PDF]

, 2011
Four chromosomal races (2n=36, 3n=54, 6n=108, 8n=144) and 96 clones have been revealed among 224 specimens of the earthworm A. rosea over the territory of Ukraine by means of karyological analysis and biochemical genetic marking.
Garbar, А. V., Kotsuba, Yu., Mezhzherіn, S. V., Vlasenкo, R. Р.   +3 more
core  

Homologies in human and Macasa fuscata chromosomes revealed by in situ suppression hybridization with human chromosome specific DNA libraries [PDF]

, 1992
We established chromosomal homologies between all chromosomes of the human karyotype and that of an old world monkey (Macaca fuscata) by chromosomal in situ suppression (CISS) hybridization with human chromosome specific DNA libraries.
Cremer, Thomas, Jauch, Anna, Stanyon, Roscoe, Wienberg, Johannes   +3 more
core   +1 more source