Results 191 to 200 of about 1,308,694 (239)

Design and Validation of Hybrid Polymer‐Lipid Nanoparticles as Novel Transfection Vectors for MicroRNA Delivery to Human Cardiac Fibroblasts

Advanced Healthcare Materials, EarlyView.
Hybrid NPs are developed as efficient, scalable nanocarriers for in vitro microRNA delivery, ensuring high loading efficiency, controlled release, physiological and long‐term storage stability. They outperform commercial lipid‐based reagents in terms of transfection efficiency and biocompatibility.
Letizia Nicoletti, Camilla Paoletti, Martina Coletto, Elena Marcello, Giovanni Paolo Stola, Francesca Cossetta, Francesco Schiavone, Ilaria Andreana, Barbara Stella, Silvia Arpicco, Clara Mattu, Valeria Chiono   +11 more
wiley   +1 more source

Evaluation of humoral and cellular immune responses in healthcare workers with varying levels of SARS-CoV-2 exposure: effects of CoronaVac vaccination followed by heterologous booster. [PDF]

Front Immunol
Gomes SMR, Ribeiro-Alves M, Ribeiro RSA, Brito ACS, Lisboa VDC, de Azevedo SG, Nogueira JS, Castilho LDR, Pôrto LCS, da Silva SAG, Dutra PML, Manfro WFP, Rodrigues LS.   +12 more
europepmc   +1 more source

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery

Advanced Healthcare Materials, EarlyView.
Lipid nanoparticles (LNPs) have rapidly become the delivery system of choice for RNA therapeutics. Here, a rational design approach is taken to improve the effectiveness of LNPs based on an ionizable thioether lipid library. The incorporation of unsaturated tails and bulkier, hydrophobic head groups significantly enhances their functionality and ...
Eleni Samaridou, Johanna Simon, Moritz Beck‐Broichsitter, Gary Davidson, Pavel A. Levkin   +4 more
wiley   +1 more source

Molecular dynamics simulation and docking studies reveals inhibition of NF-kB signaling as a promising therapeutic drug target for reduction in cytokines storms. [PDF]

Sci Rep
Kumar A, Bharadwaj T, Muthuraj L, Kumar J, Kumar P, Lalitha R, Sigamani G, Ahmad S, Bhanu P, Pathak RK, Uttarkar A, Niranjan V, Mishra V.   +12 more
europepmc   +1 more source

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J. Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L. Mangal, Abhirami P. Suresh, Niveda M. Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D. Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E. Stabenfeldt, Abhinav P. Acharya   +28 more
wiley   +1 more source

Distinct metabolome and flux responses in the retinal pigment epithelium to cytokines associated with age-related macular degeneration: comparison of ARPE-19 cells and eyecups. [PDF]

Sci Rep
Hansman DS, Lim K, Thomas D, Casson RJ, Peet DJ.   +4 more
europepmc   +1 more source

Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back, Moonkyoung Jeong, Huyen‐Thao Le, Ji‐Ho Park   +3 more
wiley   +1 more source

Rapid Reduction of Pro-Inflammatory Cytokines with an Oral Topical Composition Comprising Olive Oil, Trimethylglycine and Xylitol: A Randomized Double-Blind Controlled Trial. [PDF]

Int J Mol Sci
López-López J, Reuss JM, Vinuesa-Aumedes T, Egido-Moreno S, Roselló-Llabres X, Pereira-Riveros T, Reuss D, Alonso-Gamo L, Rodríguez-Vilaboa B.   +8 more
europepmc   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source