Results 241 to 250 of about 799,218 (270)
Advanced Healthcare Materials, EarlyView.A new dual‐layer hydrogel barrier for preventing postoperative abdominal adhesions is developed. The inner layer, consisting of polyethyleneimine (PEI) and thioctic acid (TA), enhanced adhesion to moist tissues. The outer layer combines zwitterionic, thermoresponsive hyaluronic acid with anti‐inflammatory epigallocatechin gallate (EGCG) and forms a ...
Mena Asha Krishnan +6 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth +10 more
wiley +1 more source
Imine Crosslinked, Injectable, and Self‐Healing Fucoidan Hydrogel with Immunomodulatory Properties
Advanced Healthcare Materials, EarlyView.This study develops an injectable fucoidan‐based hydrogel with tunable properties for tissue engineering. By oxidizing fucoidan (OFu) to introduce aldehydes, imine crosslinks are formed with amine‐containing polymers, enabling self‐healing, injectability, and long‐term stability (≥28 days). The OFu‐gelatin hydrogel demonstrated biocompatibility, immune‐
Asma Talib Qureshi +3 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey +5 more
wiley +1 more source
Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response
Advanced Healthcare Materials, EarlyView.In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim +11 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Qiang Zeng +9 more
wiley +1 more source
Advanced Materials, EarlyView.A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen +7 more
wiley +1 more source
Cytokine and complement levels in patients undergoing cardiopulmonary bypass
, 1993 John B. Steinberg +3 more
openalex +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma
Advanced Materials, EarlyView.A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura +19 more
wiley +1 more source