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Advanced cytokine-based immunotherapies: targeted cis-delivery strategies for enhanced anti-tumor efficacy and reduced toxicity. [PDF]
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Cytokine release syndrome in severe COVID-19
Science, 2020Lessons from arthritis and cell therapy in cancer patients point to therapy for severe disease In December 2019, a new strain of coronavirus, severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), was recognized to have emerged in Wuhan, China ...
J. B. Moore, C. June
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Cytokine Regulation and Function in T Cells.
Annual Review of Immunology, 2021T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune responses to mediate inflammation and regulate other types of immune cells.
C. Dong
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Is a "Cytokine Storm" Relevant to COVID-19?
JAMA Internal Medicine, 2020In its most severe form, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), leads to a life-threatening pneumonia and acute respiratory distress syndrome (ARDS).
P. Sinha, M. Matthay, C. Calfee
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Interleukin-6: A Masterplayer in the Cytokine Network
Oncology, 2020Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.
P. Uciechowski, W. Dempke
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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
Nature, 1994John C. Lee +17 more
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IL-6 as a keystone cytokine in health and disease
Nature Immunology, 2015C. Hunter, Simon A. Jones
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