Results 311 to 320 of about 1,857,465 (364)

Cytokine Drizzle: The Rationale for Abandoning “Cytokine Storm”

Journal of the American College of Surgeons, 2021
ABSTRACT Background: “Cytokine storm” has been used to implicate increased cytokine levels in the pathogenesis of serious clinical conditions. Similarities with Severe Acute Respiratory Syndrome Coronoavirus-2 (SARS CoV-2) and the 2012 Middle Eastern Respiratory Syndrome led early investigators to suspect a “cytokine ...
Allan E, Stolarski, Jiyoun, Kim, Qiuyang, Zhang, Daniel G, Remick   +3 more
openaire   +2 more sources

Cytokines and natural regulators of cytokines

Immunology Letters, 1994
Cytokines are polypeptide or glycopeptide signalling molecules with molecular weights from 5 to 70,000 Daltons (Table 1). They act at extremely low concentrations (picomolar and femtomolar levels) as essential mediators of infectious and immunoinflammatory reactions.
openaire   +2 more sources

Is a "Cytokine Storm" Relevant to COVID-19?

JAMA Internal Medicine, 2020
In its most severe form, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), leads to a life-threatening pneumonia and acute respiratory distress syndrome (ARDS).
P. Sinha, M. Matthay, C. Calfee
semanticscholar   +1 more source

Inhaled cytokines and cytokine antagonists

Advanced Drug Delivery Reviews, 2006
Cytokine and cytokine antagonist have provided novel and effective therapies for many human diseases. A number of approved cytokines including the interferons (alpha, beta and gamma), interleukin-2 (IL-2), granulocyte macrophage colony stimulating factor (GM-CSF) as well as novel cytokine antagonists have been administered by the pulmonary route for ...
openaire   +2 more sources

Cytokines and anti-cytokines as therapeutics — An update

European Journal of Pharmacology, 2008
Cytokines which comprise of a family of proteins--interleukins, lymphokines, monokines, interferons, and chemokines, are important components of the immune system. They act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune response.
Vandana, Tayal, Bhupinder Singh, Kalra
openaire   +2 more sources

Interleukin-6: A Masterplayer in the Cytokine Network

Oncology, 2020
Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.
P. Uciechowski, W. Dempke
semanticscholar   +1 more source

Cytokines in Cytokine Storm Syndrome

2019
As the eponymous mediators of the cytokine storm syndrome, cytokines are a pleomorphic and diverse set of soluble molecules that activate or suppress immune functions in a wide variety of ways. The relevant cytokines for each CSS are likely a result of differing combinations of environmental triggers and host susceptibilities.
openaire   +2 more sources

Update on cytokines

Journal of Allergy and Clinical Immunology, 1996
Summary Cytokines that are important in the pathophysiology of allergic disorders are summarized on Table V. The IgE isotype switch results from the activities of IL-4 and IL-13 and is inhibited by IFN-ggg and TGF-β. IL-2, IL-5, and IL-6 synergize with IL-4 and IL-13 to enhance IgE secretion.
L, Borish, L J, Rosenwasser
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Cytokines and Cytokine-Specific Therapy in Asthma

2012
Asthma is increasing in prevalence worldwide. It is characterized by typical symptoms and variable airway obstruction punctuated with episodes of worsening symptoms known as exacerbations. Underlying this clinical expression of disease is airway inflammation and remodeling.
Dhananjay, Desai, Christopher, Brightling   +1 more
openaire   +2 more sources

Anti-inflammatory Cytokines and Cytokine Antagonists

Current Pharmaceutical Design, 2000
Cytokines are critical mediators of protective host responses, including defense against microbial invasion and tumorigenesis. However, the production of specific proinflammatory cytokines must be tightly regulated and compartmentalized to prevent the overzealous expression of these molecules that can culminate in unabated inflammation and tissue ...
openaire   +2 more sources