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Naturwissenschaften, 1995
The defense of the organism against pathogens involves complex processes in which many different types of cells take part. Their functions are coordinated by polypeptide mediators collectively named cytokines. The intense research devoted to these molecules in the past has yielded an insight into their molecular characteristics, mode of action ...
H, Holtmann, K, Resch
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The defense of the organism against pathogens involves complex processes in which many different types of cells take part. Their functions are coordinated by polypeptide mediators collectively named cytokines. The intense research devoted to these molecules in the past has yielded an insight into their molecular characteristics, mode of action ...
H, Holtmann, K, Resch
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Cytokine-Cytokine Interactions in the Context of Cytokine Networking
American Journal of Respiratory Cell and Molecular Biology, 1992The start of the field of cytokine biology has been variously dated to 1951 with the discovery of nerve growth factor, 1954 with the discovery of interferon, the 1960s with the first description of "lymphokines," and 1966 with the discovery of "migration inhibitory factor" (1).
J A, Elias, R J, Zitnik
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Immunity, 2005
Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune regulation, and inflammation. Insight into their biological functions has led to novel therapeutic approaches to treat human
J. Schmitz +13 more
semanticscholar +1 more source
Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune regulation, and inflammation. Insight into their biological functions has led to novel therapeutic approaches to treat human
J. Schmitz +13 more
semanticscholar +1 more source
Cytokine–cytokine interactions and the brain
Brain Research Bulletin, 2000Cytokine-cytokine interactions play a role in health and are crucial during immunological and inflammatory responses in disease. Cytokine interactions can result in additive, antagonist, or synergistic activities in maintaining physiological functions such as feeding, body temperature, and sleep, as well as in anorectic, pyrogenic, and somnogenic ...
N P, Turrin, C R, Plata-Salamán
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Cytokine Regulation and Function in T Cells.
Annual Review of Immunology, 2021T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune responses to mediate inflammation and regulate other types of immune cells.
C. Dong
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Cytokines, antibodies to cytokines and autoimmunity
Drugs of Today, 1998It is commonly accepted that cytokines play a major role in the generation of immune responses to various stimuli, whether to exogenous antigens or to autoimmune events. This process must be regulated via complex mechanisms that maintain the normal immune homeostasis. Anti-cytokine antibodies (ACAs) are one of the components that take part in confining
H, Amital, Y, Shoenfeld
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Inhibitory cytokines and cytokine inhibitors
Neurology, 1995Cytokines such as interleukin-1 and tumor necrosis factor are involved in the triggering of the immune response, induction of acute inflammatory events, and transition to, or persistence of, chronic inflammation. The action of proinflammatory cytokines is regulated by their receptor expression, downregulation and shedding, by specific inhibitors, and ...
Burger D, Dayer JM
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Current Opinion in Immunology, 1989
Cytokines manifest multiple biological activities in different target cells, and many cytokines are produced by a variety of cell types in response to different stimuli. Furthermore, the expression of a given cytokine gene is invariably influenced by other cytokines, forming a network of ‘cytokine cascades’.
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Cytokines manifest multiple biological activities in different target cells, and many cytokines are produced by a variety of cell types in response to different stimuli. Furthermore, the expression of a given cytokine gene is invariably influenced by other cytokines, forming a network of ‘cytokine cascades’.
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Cytokine storm and sepsis disease pathogenesis
Seminars in Immunopathology, 2017Benjamin G Chousterman +2 more
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Cytokines regulate immune responses essential for maintaining immune homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders.
Nitish Kumar Bhol +7 more
semanticscholar +1 more source
Cytokines regulate immune responses essential for maintaining immune homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders.
Nitish Kumar Bhol +7 more
semanticscholar +1 more source