Results 121 to 130 of about 3,715,994 (387)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]

, 2010
The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...
Al-Riyami, Al-Riyammi, Aoyama, Baev, Bashir, Bogoyevitch, Borghouts, Bowdish, Bowdish, Bradley, Brattig, Burke, Burke, Burke, Busse, Calpe, Choubey, Clutter, Cooper, Couper, Croese, Dagia, Deehan, Diaz, Dittrich, Divangahi, Elliott, Elliott, Elliott, Everts, Fabriek, Falcone, Fulkerson, Goodridge, Goodridge, Goodridge, Goodridge, Goodridge, Gu, Hamerman, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, He, Houston, Hunter, Ishibashi, Jayapal, Johnson, Kakinuma, Katschke, Kean, Khan, Kim, King, Kitagaki, Kuroki, Lai, Lai, Lamb, Lubberts, Maizels, Mansoor, Marshall, Maurer, McInnes, McInnes, Melendez, Mendoza, Mi, Mori, Moriyama, Moriyama, Moriyama, Nagel-Wolfrum, Node, Page, Polfliet, Pushparaj, Pushparaj, Rajan, Reddy, Rioja, Rogers, Satoh, Saunders, Schnoeller, Schramm, Schramm, Steinfelder, Strickland, Subramanian, Suciu-Foca, Thalhamer, Thomas, Tilstra, van Riet, Wang, Wang, WHO, Wills-Karp, Wilson, Wohlleben, Wong, Wray, Zaccone   +111 more
core   +2 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy. [PDF]

, 2018
BACKGROUND:The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal immune mediators have been associated with pregnancy complications as well as susceptibility to ...
Ashwood, Paul, Croen, Lisa A, DeLorenze, Gerald N, Heuer, Luke S, Jones, Karen L, Kharrazi, Martin, Traglia, Michela, Van de Water, Judy, Weiss, Lauren A, Yolken, Robert   +9 more
core  

Latent Kaposi's Sarcoma-Associated Herpesvirus Infection of Monocytes Downregulates Expression of Adaptive Immune Response Costimulatory Receptors and Proinflammatory Cytokines [PDF]

, 2012
Sean M. Gregory, Ling Wang, John A. West, Dirk P. Dittmer, Blossom Damania   +4 more
openalex   +1 more source

Supplementary Figure 1 from Tumor-Induced Suppressor of Cytokine Signaling 3 Inhibits Toll-like Receptor 3 Signaling in Dendritic Cells via Binding to Tyrosine Kinase 2 [PDF]

, 2023
Bin Zeng, Haijie Li, Yu Liu, Zhuohan Zhang, Yuan Zhang, Rongcun Yang   +5 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Association Between Gene Polymorphisms of Inflammatory Cytokines and Vitamin D Receptor Gene with the Risk of Insulin Resistance and Dyslipidemia in Type 2 Diabetic Patients

, 2022
Moushira Zaki, S Assaad Khalil, M Megallaa, K Rohoma, H Ismael, M Abouseif, I Kharboush, D Elkaffash, M Hassanein, M Abdel Wahab, A Malaty, S Wild, G Roglic, A Green, R Sicree, H King, E Collaboration, S Paul, R Kulal, R Nath, K Rodrigues, N Pietrani, V Sandrim, C Vieira, A Fernandes, A Bosco, K Gomes, J Lee, C Herder, M Carstensen, D Ouwens, J.-P Bastard, C Jardel, E Bruckert, P Blondy, J Capeau, M Laville, H Vidal, B Hainque, D Hansen, P Dendale, M Beelen, R Jonkers, A Mullens, L Corluy, R Meeusen, L Van Loon, P Kern, S Ranganathan, C Li, L Wood, G Ranganathan, R Starkie, S Ostrowski, S Jauffred, M Febbraio, B Pedersen, J Senn, P Klover, I Nowak, T Zimmers, L Koniaris, R Furlanetto, R Mooney, K Rehman, M Akash, A Liaqat, S Kamal, M Qadir, A Rasul, S Rasool, O Qasim, S Muslem, M Al-Taee, V Boraska, N Rayner, C Groves, T Frayling, M Diakite, K Rockett, D Kwiatkowski, A Day-Williams, M Mccarthy, E Zeggini, C Cefalo, C Conte, G Sorice, S Moffa, V Sun, F Cinti, E Salomone, G Muscogiuri, A Brocchi, A Pontecorvi, A Pramono, J Jocken, M Adriaens, M Hjorth, A Astrup, W Saris   +99 more
openalex   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source