Results 131 to 140 of about 517,948 (338)

A strategy to design protein-based antagonists against type I cytokine receptors.

PLoS Biology
Excessive cytokine signaling resulting from dysregulation of a cytokine or its receptor can be a main driver of cancer, autoimmune, or hematopoietic disorders.
Timo Ullrich, Olga Klimenkova, Christoph Pollmann, Asma Lasram, Valeriia Hatskovska, Kateryna Maksymenko, Matej Milijaš-Jotić, Lukas Schenk, Claudia Lengerke, Marcus D Hartmann, Jacob Piehler, Julia Skokowa, Mohammad ElGamacy   +12 more
doaj   +1 more source

Goose Hepatic IGFBP2 Is Regulated by Nutritional Status and Participates in Energy Metabolism Mainly through the Cytokine-Cytokine Receptor Pathway. [PDF]

Animals (Basel), 2023
Li F, Xing Y, Zhang J, Mu J, Ge J, Zhao M, Liu L, Gong D, Geng T.   +8 more
europepmc   +1 more source

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP‐IgG‐positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio‐Techne).
Yahel Segal, Georgios Mangioris, Vanda Lennon, Binxia Yang, Divyanshu Dubey, Eoin P. Flanagan, Andrew McKeon, John R. Mills, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +11 more
wiley   +1 more source

A novel TRIM22 gene polymorphism promotes the response to PegIFNα therapy through cytokine-cytokine receptor interaction signaling pathway in chronic hepatitis B. [PDF]

Microbiol Spectr, 2023
Wang L, Lin N, Zhang Y, Guo S, Liu C, Lin C, Zeng Y, Wu W, Guo J, Zhu C, Zhan F, Ou Q, Xun Z.   +12 more
europepmc   +1 more source

Cytokine and Cytokine Receptor Pleiotropy and Redundancy [PDF]

Journal of Biological Chemistry, 2002
Warren J. Leonard, Katsutoshi Ozaki
openaire   +2 more sources

Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist

, 1994
John Mansfield, Hazel M. Holden, Joanna K. Tarlow, Francesco S. di Giovine, Tarra L. McDowell, Anthony G. Wilson, C D Holdsworth, Gordon W. Duff   +7 more
openalex   +1 more source

Combined Systemic Immunotherapy and Intrathecal Dexamethasone in Febrile Infection Related Epilepsy Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Febrile infection related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus with immune dysregulation as a potential pathologic mechanism. Despite promising results from second‐line immunomodulators, approximately 30% remain refractory to treatment.
Kristen S. Fisher, Alexander Ankar, Jon Cokley, Eyal Muscal, James J. Riviello, Yi‐Chen Lai   +5 more
wiley   +1 more source

A common single nucleotide variant in the cytokine receptor-like factor-3 (CRLF3) gene causes neuronal deficits in human and mouse cells. [PDF]

Hum Mol Genet, 2023
Wilson AF, Barakat R, Mu R, Karush LL, Gao Y, Hartigan KA, Chen JK, Shu H, Turner TN, Maloney SE, Mennerick SJ, Gutmann DH, Anastasaki C.   +12 more
europepmc   +1 more source

Cytokine regulation of low density lipoprotein receptor gene transcription in HepG2 cells

, 1993
Alison Stopeck, Andrew Nicholson, Francesco Paolo Mancini, D P Hajjar   +3 more
openalex   +1 more source

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A. Thackaberry, Marco Colonna, Raj Rajagovindan   +8 more
wiley   +1 more source