Results 11 to 20 of about 3,593,223 (396)

Mapping Determinants of Cytokine Signaling via Protein Engineering [PDF]

Frontiers in Immunology, 2018
Cytokines comprise a large family of secreted ligands that are critical for the regulation of immune homeostasis. Cytokines initiate signaling via dimerization or oligomerization of the cognate receptor subunits, triggering the activation of the Janus ...
Claire Gorby, Jonathan Martinez-Fabregas, Stephan Wilmes, Ignacio Moraga   +3 more
doaj   +5 more sources

IL-21 receptor expression in human tendinopathy [PDF]

, 2014
The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role.
Campbell, Abigail L., Fazzi, Umberto G., Kerr, Shauna C., Leach, William J., Millar, Neal L., Murrell, George A.C., Reilly, James H., Rooney, Brian P., Smith, Nicola C.   +8 more
core   +7 more sources

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

eLife, 2023
Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM) helices within a receptor ...
Jean-Philippe Defour, Emilie Leroy, Sharmila Dass, Thomas Balligand, Gabriel Levy, Ian C Brett, Nicolas Papadopoulos, Céline Mouton, Lidvine Genet, Christian Pecquet, Judith Staerk, Steven O Smith, Stefan N Constantinescu   +12 more
doaj   +1 more source

Identification of cytokine-induced cell communications by pan-cancer meta-analysis [PDF]

PeerJ, 2023
Cancer immune responses are complex cellular processes in which cytokine–receptor interactions play central roles in cancer development and response to therapy; dysregulated cytokine–receptor communication may lead to pathological processes, including ...
Yining Liu, Min Zhao, Hong Qu
doaj   +2 more sources

Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor [PDF]

Open Biology, 2012
Certain disulfide bonds present in leucocyte membrane proteins are labile and can be reduced in inflammation. This can cause structural changes that result in downstream functional effects, for example, in integrin activation.
Clive Metcalfe, Peter Cresswell, A. Neil Barclay   +2 more
doaj   +1 more source

Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer

Cancer Medicine, 2021
The colony stimulating factor 2 receptor subunit beta (CSF2RB) is the common signaling subunit of the cytokine receptors for IL‐3, IL‐5, and GM‐CSF. Several studies have shown that spontaneous and random mutants of CSF2RB can lead to ligand independence ...
Mamoon Rashid, Rizwan Ali, Bader Almuzzaini, Hao Song, Alshaimaa AlHallaj, Al Abdulrahman Abdulkarim, Omar Mohamed Baz, Hajar Al Zahrani, Muhammed Mustafa Sabeena, Wardah Alharbi, Mohamed Hussein, Mohamed Boudjelal   +11 more
doaj   +1 more source

Safe eradication of large established tumors using neovasculature‐targeted tumor necrosis factor‐based therapies

EMBO Molecular Medicine, 2020
Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index.
Leander Huyghe, Alexander Van Parys, Anje Cauwels, Sandra Van Lint, Stijn De Munter, Jennyfer Bultinck, Lennart Zabeau, Jeroen Hostens, An Goethals, Nele Vanderroost, Annick Verhee, Gilles Uzé, Niko Kley, Frank Peelman, Bart Vandekerckhove, Peter Brouckaert, Jan Tavernier   +16 more
doaj   +1 more source

Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression

Frontiers in Molecular Biosciences, 2022
Objective: Osteoarthritis (OA) is the most common chronic degenerative joint disease, which represents the leading cause of age-related disability. Here, this study aimed to depict the intercellular heterogeneity of OA synovial tissues.Methods: Single ...
Wenzhou Liu, Yanbo Chen, Gang Zeng, Shuting Yang, Tao Yang, Mengjun Ma, Weidong Song   +6 more
doaj   +1 more source

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma [PDF]

, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a
Beyaert, Rudi, Braun, Harald, Dansercoer, Ann, De Winter, Hans, Hammad, Hamida, Lambrecht, Bart, Lippens, Guy, Lopez, Juan, Pauwels, Kris, Peelman, Frank, Savvides, Savvas, Tavernier, Jan, Van Rompaey, Dries, Vandenberghe, Isabel, Verstraete, Kenneth   +14 more
core   +2 more sources

Cytokine Receptor

Definitions, 2020
A cytokine receptor is a protein on the cell surface that specifically binds cytokine ligands which are small proteins secreted by immune cells. These receptors mediate molecular functions such as signal transduction.

semanticscholar   +1 more source