Results 11 to 20 of about 3,715,994 (387)
Frontiers in Molecular Neuroscience, 2017 The cytokine erythropoietin (Epo) mediates various cell homeostatic responses to environmental challenges and pathological insults. While stimulation of vertebrate erythrocyte production is mediated by homodimeric “classical” Epo receptors, alternative ...
Nina Hahn +10 more
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Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. [PDF]
Science, 2022 Cytokines signal through cell surface receptor dimers to initiate activation of intracellular Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy structure of full-length JAK1 complexed with a cytokine receptor ...
Glassman CR +5 more
europepmc +2 more sources
Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins. [PDF]
Nat Biotechnol, 2023 Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an important means to modulate extracellular biology. However, these approaches have limitations due to lack of modularity, ease of development, restricted tissue ...
Pance K +7 more
europepmc +2 more sources
Definitions, 2020 A cytokine receptor is a protein on the cell surface that specifically binds cytokine ligands which are small proteins secreted by immune cells. These receptors mediate molecular functions such as signal transduction.
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Soluble cytokine receptors [PDF]
Blood, 1996 HE WORD “HORMONE” comes from the Greek, meaning to set in motion, whereas “humoral” comes from the Latin for ‘‘liquid.’’ Classical hormones are delivered in the blood “to set in motion” target cell proliferation or functional activation. Therefore, humoral specificity depends on the hormone’s ability to interact only with cells expressing the ...
M L, Heaney, D W, Golde
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Science, 2020 Activated by interaction Cytokines trigger immune responses when they bind to their cognate receptors. Class I cytokine receptors rely on the associated Janus kinase 2 (JAK2) to initiate signal transduction.
S. Wilmes +18 more
semanticscholar +1 more source
THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling
Annual Review of Immunology, 1997 Erika A Bach +2 more
openalex +3 more sources
Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor [PDF]
Open Biology, 2012 Certain disulfide bonds present in leucocyte membrane proteins are labile and can be reduced in inflammation. This can cause structural changes that result in downstream functional effects, for example, in integrin activation.
Clive Metcalfe +2 more
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Identification of cytokine-induced cell communications by pan-cancer meta-analysis [PDF]
PeerJ, 2023 Cancer immune responses are complex cellular processes in which cytokine–receptor interactions play central roles in cancer development and response to therapy; dysregulated cytokine–receptor communication may lead to pathological processes, including ...
Yining Liu, Min Zhao, Hong Qu
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Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer
Cancer Medicine, 2021 The colony stimulating factor 2 receptor subunit beta (CSF2RB) is the common signaling subunit of the cytokine receptors for IL‐3, IL‐5, and GM‐CSF. Several studies have shown that spontaneous and random mutants of CSF2RB can lead to ligand independence ...
Mamoon Rashid +11 more
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