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Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
Journal of Xenobiotics, 2022 The endocrine disruptors are mostly small organic molecules developed for numerous and very diverse industrial applications. They essentially act through nuclear receptors with small and hydrophobic endogenous ligands.
Yves Combarnous, Thi Mong Diep Nguyen
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Soluble cytokine receptors [PDF]
Blood, 1996 HE WORD “HORMONE” comes from the Greek, meaning to set in motion, whereas “humoral” comes from the Latin for ‘‘liquid.’’ Classical hormones are delivered in the blood “to set in motion” target cell proliferation or functional activation. Therefore, humoral specificity depends on the hormone’s ability to interact only with cells expressing the ...
David W. Golde, Mark L. Heaney
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Frontiers in Immunology, 2019 Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS).
Nadia Bougarne +24 more
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Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies
Pharmaceuticals, 2021 The cytokine interleukin-7 (IL-7) and its receptor are critical for lymphoid cell development. The loss of IL-7 signaling causes severe combined immunodeficiency, whereas gain-of-function alterations in the pathway contribute to malignant transformation ...
Inge Lodewijckx, Jan Cools
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Scientific Reports, 2017 The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s ligand ...
Ioanna Petta +12 more
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Frontiers in Molecular Neuroscience, 2019 The orphan cytokine receptor-like factor 3 (CRLF3) was identified as a neuroprotective erythropoietin receptor in locust neurons and emerged with the evolution of the eumetazoan nervous system.
Nina Hahn +8 more
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Macrophage-derived upd3 Cytokine causes impaired glucose homeostasis and reduced lifespan in drosophila fed a lipid-rich diet [PDF]
, 2014 Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that ...
Dionne, MS +5 more
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Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads
Frontiers in Immunology, 2017 Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Chandra S. Chirumamilla +18 more
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Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
Science, 2019 Exploring a range of signaling Cytokines are small proteins that bind to the extracellular domains of transmembrane receptors to activate signaling pathways inside the cell.
K. Mohan +12 more
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Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease
Molecular Neurodegeneration, 2018 Background Neuronal Ca2+ dyshomeostasis and hyperactivity play a central role in Alzheimer’s disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer’s disease contributes to increased Ca2+ influx and aberrant ...
Michael Dumbacher +16 more
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