Results 31 to 40 of about 3,715,994 (387)
Frontiers in Molecular Neuroscience, 2019 The orphan cytokine receptor-like factor 3 (CRLF3) was identified as a neuroprotective erythropoietin receptor in locust neurons and emerged with the evolution of the eumetazoan nervous system.
Nina Hahn +8 more
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Role of IL-33 in inflammation and disease [PDF]
, 2011 Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is expressed by mainly stromal cells, such as epithelial and endothelial cells, and its expression is upregulated following pro-inflammatory stimulation.
Miller, Ashley M.
core +3 more sources
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
Science, 2019 Exploring a range of signaling Cytokines are small proteins that bind to the extracellular domains of transmembrane receptors to activate signaling pathways inside the cell.
K. Mohan +12 more
semanticscholar +1 more source
Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads
Frontiers in Immunology, 2017 Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Chandra S. Chirumamilla +18 more
doaj +1 more source
Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice [PDF]
, 2001 Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson S. +64 more
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Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease
Molecular Neurodegeneration, 2018 Background Neuronal Ca2+ dyshomeostasis and hyperactivity play a central role in Alzheimer’s disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer’s disease contributes to increased Ca2+ influx and aberrant ...
Michael Dumbacher +16 more
doaj +1 more source
Pharmacology Research & Perspectives, 2019 Janus kinase (JAK) inhibitors have emerged as an effective class of therapies for various inflammatory diseases such as rheumatoid arthritis (RA). JAK inhibitors function intracellularly by modulating the catalytic activity of JAKs and disrupting the ...
M. Dowty +7 more
semanticscholar +1 more source
Scientific Reports, 2017 The glucocorticoid receptor (GR) is a transcription factor of which the underlying gene regulatory mechanisms are complex and incompletely understood. The non-steroidal anti-inflammatory Compound A (CpdA), a selective GR modulating compound in various ...
S. J. Desmet +9 more
doaj +1 more source
Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. [PDF]
, 2018 HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination
DeChristopher, Brian A +11 more
core +1 more source
The case for absolute ligand discrimination : modeling information processing and decision by immune T cells [PDF]
, 2015 Some cells have to take decision based on the quality of surroundings ligands, almost irrespective of their quantity, a problem we name "absolute discrimination". An example of absolute discrimination is recognition of not-self by immune T Cells. We show
Altan-Bonnet, Grégoire, François, Paul
core +2 more sources