Results 41 to 50 of about 3,547,192 (423)

Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression [PDF]

Cellular Immunology, 2008
Opioids were originally discovered because of their ability to induce analgesia, but further investigation has shown that the opioids regulate the function of cells involved in the immune response. We suggest that the regulation of cytokine, chemokine, and cytokine receptor expression is a critical component of the immunomodulatory activity of the ...
Christine Happel, Matthew J. Finley, Thomas J. Rogers, D. E. Kaminsky   +3 more
openaire   +3 more sources

The Common Cytokine Receptor γ Chain Family of Cytokines.

Cold Spring Harbor Perspectives in Biology, 2018
Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their sharing the common cytokine receptor γ chain (γc), which was originally discovered as the third receptor component of the IL-2 receptor, IL-2Rγ.
Jian-Xin Lin, W. Leonard
semanticscholar   +1 more source

Metareview-informed Explainable Cytokine Storm Detection during CAR-T cell Therapy [PDF]

arXiv, 2022
Cytokine release syndrome (CRS), also known as cytokine storm, is one of the most consequential adverse effects of chimeric antigen receptor therapies that have shown promising results in cancer treatment. When emerging, CRS could be identified by the analysis of specific cytokine and chemokine profiles that tend to exhibit similarities across patients.
arxiv  

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-kappa B activation [PDF]

, 2014
Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders ...
Baker, D, Cerutti, C, de Vries, HE, Hirst, MC, King-Robson, J, Lopez-Ramirez, MA, Male, DK, Michael, GJ, Pryce, G, Romero, IA, Sharrack, B, Simpson, JE, van der Pol, SMA, Wu, D   +13 more
core   +2 more sources

Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]

arXiv, 2022
The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv  

Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice [PDF]

, 2001
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson S., Anderson S., Anderson S., Artis D., Bancroft A. J., Bancroft A. J., Barner M., Belkaid Y., Brewer J. M., Brombacher F., Coulson P. S., D'Andrea A., de Andres B., Dean D. A., Delgado V., Donaldson D. D., Faquim-Mauro E. L., Galbiati F., Grunig G., Guler M. L., Hilton D. J., Hoffmann K. F., Hsieh C. S., James S. L., Jankovic D., Jankovic D., Jankovic D., King C. L., King C. L., Kopf M., Magram J., Mangold B. L., Matthews D. J., Mattner F., McKenzie G. J., Metwali A., Mohrs M., Mohrs M., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Muchamuel T., Nelms K., Noben-Trauth N., Noben-Trauth N., Noben-Trauth N., O'Garra A., Pearce E. J., Reiner S. L., Scott P., Seder R. A., Sher A., Shibuya K., Smythies L. E., Smythies L. E., Street M., Szabo S. J., Urban J. F., Wilson R. A., Wynn T. A., Wynn T. A., Zurawski G.   +64 more
core   +2 more sources

P1 receptors and cytokine secretion [PDF]

Purinergic Signalling, 2007
Evidence has accumulated in the last three decades to suggest tissue protection and regeneration by adenosine in multiple different cell types. Adenosine produced in hypoxic or inflamed environments reduces tissue injury and promotes repair by receptor-mediated mechanisms.
M.P. Abbracchio, S. Ceruti
openaire   +3 more sources

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

bioRxiv, 2019
Cytokines activate downstream signaling networks via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes.
J. Martínez-Fábregas, S. Wilmes, Luopin Wang, M. Hafer, E. Pohler, J. Lokau, Christoph Garbers, A. Cozzani, J. Piehler, M. Kazemian, Suman Mitra, Ignacio Moraga Gonzalez   +11 more
semanticscholar   +1 more source

Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy

Nature reviews. Immunology, 2021
A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting specific signalling pathways, have been joined by cellular immunotherapies ...
E. Morris, S. Neelapu, Theodoros Giavridis, M. Sadelain   +3 more
semanticscholar   +1 more source

Cell Surface Markers in HTLV-1 Pathogenesis

Viruses, 2011
The phenotype of HTLV-1-transformed CD4+ T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors ...
Andrea K. Kress, Bernhard Fleckenstein, Ralph Grassmann   +2 more
doaj   +1 more source