Results 51 to 60 of about 3,593,223 (396)
Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase
Frontiers in Endocrinology, 2018 JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1–3 and TYK2. JAKs serve as the cytoplasmic signaling components of cytokine receptors and are activated through cytokine-mediated trans ...
Stevan R. Hubbard
doaj +1 more source
Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K
Frontiers in Endocrinology, 2017 Type I and II cytokine receptors are cell surface sensors that bind cytokines in the extracellular environment and initiate intracellular signaling to control processes such as hematopoiesis, immune function, and cellular growth and development.
Lily Jun-shen Huang +2 more
doaj +1 more source
Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. [PDF]
PLoS ONE, 2011 Length and intensity of signal transduction via cytokine receptors is precisely regulated. Degradation of certain cytokine receptors is mediated by the ubiquitin ligase SCF(βTrCP).
Joyce Putters +5 more
doaj +1 more source
Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes
Frontiers in Immunology, 2018 Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic inflammation. They play important roles in regulating the responses of lymphocytes, myeloid cells, and non-hematopoietic cells.
I. Junttila
semanticscholar +1 more source
, 2004 Complementary (antisense) peptide mini-receptor inhibitors are complementary peptides designed to be receptor-surrogates that act by binding to selected surface features of biologically important proteins thereby inhibiting protein-cognate receptor ...
Bhakoo, Ashish +4 more
core +1 more source
HiJAKing innate lymphoid cells? [PDF]
, 2017 The family of innate lymphoid cells (ILCs) consists of a heterogeneous group of cytokine-producing cells that have features in common with adaptive T helper (Th) cells.
Gadina, Massimo +2 more
core +1 more source
Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction [PDF]
, 2015 Oxidative stress in heart failure or during ischemia/reperfusion occurs as a result of the excessive generation or accumulation of free radicals or their oxidation products.
Cerretani D. +6 more
core +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
Frontiers in Physiology, 2014 Granulocyte-colony stimulating factor (G-CSF) increases recovery of rodent skeletal muscles after injury, and increases muscle function in rodent models of neuromuscular disease.
Craig Robert Wright +5 more
doaj +1 more source
Cancer Discovery, 2016 UNLABELLED Chimeric antigen receptor (CAR)-modified T cells with anti-CD19 specificity are a highly effective novel immune therapy for relapsed/refractory acute lymphoblastic leukemia.
D. Teachey +26 more
semanticscholar +1 more source