Results 81 to 90 of about 3,593,223 (396)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation

Nature Communications, 2022
The mode of cytokine receptor activation is diverse. Here, the authors find that the marine-sponge derived lectin ThC, a bivalent sugar binding protein, activates human cytokine receptor MPL. This mode of action resembles the pathogenic activation of MPL
Hiromi Watari, Hiromu Kageyama, Nami Masubuchi, Hiroya Nakajima, Kako Onodera, Pamela J. Focia, Takumi Oshiro, Takashi Matsui, Yoshio Kodera, Tomohisa Ogawa, Takeshi Yokoyama, Makoto Hirayama, Kanji Hori, Douglas M. Freymann, Misa Imai, Norio Komatsu, Marito Araki, Yoshikazu Tanaka, Ryuichi Sakai   +18 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Cytokines of Birds: Conserved Functions [PDF]

, 2001
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F., Kaspers, Bernd, Puehler, Florian, Schneider, Kirsten, Staeheli, Peter   +4 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

T-Cell activation: a queuing theory analysis at low agonist density [PDF]

, 2006
We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Bossi, Chan, Chan, Chan, Coombs, Das, Dittel, Dummer, Dustin, Dustin, Dustin, Faeder, Faroudi, Freiberg, Gett, Grakoui, Gunzer, Hemmer, Hoffmann, Hopfield, Huppa, Iezzi, Irvine, Itoh, J.R. Wedagedera, Kedl, Kersh, Krogsgaard, Krummel, Lee, Lewis, Lezzi, Li, Liu, Lollo, Lyons, N.J. Burroughs, Noest, Purbhoo, Rabinowitz, Randriamampita, Rees, Revy, S McKeithan, Schluns, Schrum, Schwarzmann, Sousa, Stefanova, Valitutti, Valitutti, Valitutti, van Bergen, van den Berg, van der Merwe, van Stipdonk, Veillette, Weiss, Werlen, Wofsy, Wulfing, Yang   +61 more
core   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Combination of levofloxacin and cisplatin enhances anticancer efficacy via co-regulation of eight cancer-associated genes

Discover Oncology, 2022
Chemosensitizer or combined chemotherapy can sensitize cancer cells to therapy and minimize drug resistance. We reveal that levofloxacin has broad-spectrum anticancer activity.
Xiaoqiong He, ·Qian Yao, Dan Fan, Yutong You, Wenjing Lian, Zhangping Zhou, Ling Duan   +6 more
doaj   +1 more source

Reversal of tumor immune inhibition using a chimeric cytokine receptor.

Molecular Therapy, 2014
The success of adoptively transferred tumor-directed T cells requires them to survive and expand in vivo. Most tumors, however, employ immune evasion mechanisms, including the production of inhibitory cytokines that limit in vivo T-cell persistence and ...
A. Leen, S. Sukumaran, N. Watanabe, Somala Mohammed, J. Keirnan, R. Yanagisawa, U. Anurathapan, David Rendon, H. Heslop, C. Rooney, M. Brenner, J. Vera   +11 more
semanticscholar   +1 more source

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. [PDF]

, 2016
Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung.
Austen, K Frank, Barrett, Nora A, Kanaoka, Yoshihide, Locksley, Richard M, O'Leary, Claire E, von Moltke, Jakob   +5 more
core   +1 more source