Results 161 to 170 of about 2,857,482 (280)

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Cytokine Release Syndrome after Haploidentical Transplantation is Associated with Improved Survival Without Increasing Transplant-Related Mortality. [PDF]

Mediterr J Hematol Infect Dis
Avenoso D, Difrancesco N, Morello E, Magliano G, Farina M, Radici V, Hanmantgad S, Bernardi S, Re F, Leoni A, Russo D, Malagola M.   +11 more
europepmc   +1 more source

Low Dose Tocilizumab for Mitigation of Cytokine Release Syndrome With T-Cell Engaging Bispecific Antibodies. [PDF]

Clin Lymphoma Myeloma Leuk
Hamadeh IS, Merz M, Derkach A, Modelevsky L, Lesokhin AM, Mailankody S, Hultcrantz ML, Tan CR, Hassoun H, Shah UA, Maclachlan K, Rajeeve S, Hashmi H, Maura F, Firestone RS, Wang AX, Amin A, Patel D, Scordo M, Shah GL, Landau HJ, Giralt S, Usmani SZ, Korde N.   +23 more
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Epcoritamab Step-Up Dosing Regimen Selection and Optimization Using Repeated Time-to-Event Modeling for Cytokine Release Syndrome Risk Mitigation. [PDF]

Clin Pharmacol Ther
Li T, Tredennick A, Polhamus D, Putnins M, Liu S, Sanghavi K, Thalhauser CJ, Parikh A, Noorani B, Mohamed MF, Le Gallo C, Elliott B, Gupta M, Xu S.   +13 more
europepmc   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Detection of cytokine release syndrome using wearables and cytokine profiling following CAR-T therapy for myeloma. [PDF]

JCI Insight
Rajeeve S, Wilkes M, Zahradka N, Tomalin L, Quidwai M, Pan D, Calafat NJ, Cusack M, Aleman A, Serebryakova K, Kappes K, Jackson H, Agte S, Thibaud S, Sanchez L, Richard S, Richter J, Rodriguez C, Cho HJ, Chari A, Jagannath S, Laganà A, Rossi AC, Parekh S.   +23 more
europepmc   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

Enhancing persistence while managing cytokine release syndrome to embrace next-generation CAR-T cell therapy. [PDF]

J Transl Med
Yang Y, Sun Y, Kang H, Guan E, Liu R, Yang K, Jiang D.   +6 more
europepmc   +1 more source