Results 231 to 240 of about 318,819 (293)

Massive immune-related myositis and cytokine release syndrome during dual immunotherapy plus chemotherapy for recurrent lung adenocarcinoma: case report. [PDF]

Respir Med Case Rep
Nakai S, Inoue Y, Karayama M, Yasui H, Suzuki Y, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Suda T.   +10 more
europepmc   +1 more source

Experimental and clinical evidence of leukocyte activation in trauma and sepsis [PDF]

, 1994
Bahrami, S., Bengtsson, A., Davies, J., Jochum, Marianne, Levin, Jack, Redl, H., Schlag, G.   +6 more
core  

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi, Miriam T. Jackson, Cindy C. Shu, Susan M. Smith, Margaret M. Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R. Scanzello, Christopher B. Little   +10 more
wiley   +1 more source

m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis. [PDF]

Front Immunol
Moreno-Castaño AB, Fernández S, Brillembourg H, Iraola G, Moreno DF, Ventosa-Capell H, Martinez-Sanchez J, De Moner B, Molina P, Ramos A, Palomo M, Gómez-Ramírez P, Ortiz-Maldonado V, Martínez-Cibrián N, Delgado J, Oliver-Caldés A, Fernández de Larrea C, Salas MQ, Urbano Á, Téllez A, Nicolás JM, Juan M, González-Navarro A, Penack O, Escolar G, Carreras E, Fernández-Avilés F, Castro P, Diaz-Ricart M.   +28 more
europepmc   +1 more source

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

Emapalumab for severe cytokine release syndrome in solid tumor CAR-T: a case report. [PDF]

Front Oncol
Ruemmele T, Macedo R, Stein MN, Chan HT, Mapara MY, Jacquemont CF, Reshef R.   +6 more
europepmc   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Cytokine Release Syndrome and Neurotoxicity Following CD19 CAR-T in B-Cell Lymphoma. [PDF]

Transplant Cell Ther
Shouval R, Strouse C, Kim S, Oloyede T, Ahmed S, Awan FT, Luan D, Bachanova V, Badar T, Bar M, Barba P, Beitinjaneh AM, Cashen A, Dholaria B, Elsawy M, Ganguly S, Geethakumari PR, Greenbaum U, Hashmi H, Hill LC, Jain MD, Jain T, Kebriaei P, Kittai AS, Locke FL, Lulla PD, Mead E, McGuirk JP, Mussetti A, Nishihori T, Olson AL, Pennisi M, Perales MA, Riedell PA, Saber W, Mirza AS, Magalhaes-Silverman M, Shpall EJ, Sorror M, Wudhikarn K, Turtle CJ, Moskop A, Pasquini MC.   +42 more
europepmc   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Teclistamab-associated cytokine release syndrome in multiple myeloma: a case-based literature review of mechanisms, management, and clinical implications. [PDF]

Arch Clin Cases
Cheema M, Syed S, Ghuman Z, Iftikhar A.
europepmc   +1 more source