Results 91 to 100 of about 1,666,972 (256)

A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls

Frontiers in Immunology, 2019
Cytokines and chemokines are key signaling molecules of the immune system. Recent technological advances enable measurement of multiplexed cytokine profiles in biological samples.
Liel Cohen, Liel Cohen, Andrew Fiore-Gartland, Adrienne G. Randolph, Adrienne G. Randolph, Angela Panoskaltsis-Mortari, Sook-San Wong, Jacqui Ralston, Timothy Wood, Ruth Seeds, Q. Sue Huang, Richard J. Webby, Paul G. Thomas, Tomer Hertz, Tomer Hertz, Tomer Hertz   +15 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Experimentally observed enhancement of cytokine signaling by cytokine-neutralizing antibodies (CNAs).

, 2016
Experimentally observed enhancement of cytokine signaling by cytokine-neutralizing antibodies (CNAs).
Yuri Kosinsky (1778548), Boris Shulgin (1778545), Gabriel Helmlinger (704898)   +2 more
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health

Cells
Chronic inflammation is increasingly recognized as a critical factor in female reproductive health; influencing natural conception and the outcomes of assisted reproductive technologies such as in vitro fertilization (IVF).
Efthalia Moustakli, Sofoklis Stavros, Periklis Katopodis, Charikleia Skentou, Anastasios Potiris, Periklis Panagopoulos, Ekaterini Domali, Ioannis Arkoulis, Theodoros Karampitsakos, Eleftheria Sarafi, Theologos M. Michaelidis, Athanasios Zachariou, Athanasios Zikopoulos   +12 more
doaj   +1 more source

Nuclear localization of Suppressor of Cytokine Signaling (SOCS)-1 regulates local immunity in the lung

Frontiers in Immunology, 2016
Suppressor of cytokine signaling 1 (SOCS1) is a negative feedback inhibitor of cytoplasmic Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling.
Jana Zimmer, Michael Weitnauer, Sébastien Boutin, Sébastien Boutin, Sébastien Boutin, Günter Küblbeck, Sabrina Thiele, Patrick Walker, Felix Lasitschka, Lars Lunding, Lars Lunding, Zane Orinska, Zane Orinska, Christina Vock, Christina Vock, Bernd Arnold, Michael Wegmann, Michael Wegmann, Alexander Dalpke, Alexander Dalpke, Alexander Dalpke   +20 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

PCR measurements for cytokine-inducible SH-containing protein, suppressors of cytokine signaling-2 and suppressors of cytokine signaling-3

, 2011
Copyright information:Taken from "Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent ...
Anthony J Kee (38853), Michael J O'Leary (38849), Ross C Smith (38854), Christopher J Scarlett (38851), Aiqun Xue (38850), Andre Sevette (38852)   +5 more
core   +1 more source

Deep Learning-Based Modeling of Tumor-Associated Cytokine and Endocrine System Interactions

IEEE Access
The interactions between tumor-associated cytokine signaling and the endocrine system play a critical role in both the progression of malignancies and systemic physiological dysregulation.
Haiyan Xu, Yuanyuan Qin
doaj   +1 more source