Results 111 to 120 of about 1,666,972 (256)

Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways

, 2011
Various cytokines are involved in the regulation of the immune system and inflammation. Dysregulation of cytokine signaling can cause a variety of diseases, including allergy, autoimmune diseases, inflammation, and cancer.
Hideo Yasukawa, Akihiko Yoshimura, Ikko Kashiwagi, Reiko Takahashi, Taiga Tamiya   +4 more
core   +1 more source

GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection

Infection and Immunity
The proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is required for host defense against a wide range of pathogens. During infection with the intracellular bacterial pathogen Legionella pneumophila, we previously found ...
Víctor R. Vázquez Marrero, Madison Dresler, Mikel D. Haggadone, Allyson Lu, Sunny Shin   +4 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

ESCRT proteins restrict constitutive NF-kappa B signaling by trafficking cytokine receptors

, 2016
Because signaling mediated by the transcription factor nuclear factor kappa B (NF-kappa B) is initiated by ligands and receptors that can undergo internalization, we investigated how endocytic trafficking regulated this key physiological pathway.
Maminska, Agnieszka, Banach-Orłowska, Magdalena, Simonsen, Anne, Piwocka, Katarzyna, Wolinska-Niziol, Lidia, Bartosik, Anna, Banach-Orlowska, Magdalena, Stenmark, Harald, Castanon, Irinka, Kowalczyk, Agata, Pilecka, Iwona, Poulain, Morgane, Torun, Anna, Castanon Ortega, Irinka, Fürthauer, Maximilian, Gonzalez Gaitan, Marcos, Jastrzebski, Kamil, Gonzalez-Gaitan, Marcos, Wolińska-Nizioł, Lidia, Zdzalik-Bielecka, Daria, Szymanska, Ewelina, Miaczynska, Marta, Neyen, Claudine, Fuerthauer, Maximilian, Piwocka K, Miaczynska M, Jastrzębski K, Mamińska A, Pilecka I, Banach-Orłowska M, Wolińska-Nizioł L, Szymańska E, Neyen C, González-Gaitán M, Simonsen A, Poulain M, Bartosik A, Zdżalik-Bielecka D, Toruń A, Kowalczyk A, Fürthauer M, Castanon I, Stenmark H   +42 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death

, 2009
Pancreatic beta cell damage caused by pro-inflammatory cytokines interleukin-1 beta (IL-1 beta), interferon-gamma (IFN gamma) and tumor necrosis factor-alpha (TNF alpha) is a key event in the pathogenesis of type 1 diabetes.
Sharoyko, Vladimir, Hultcrantz, Monica, Zaitsev, Sergei V., Flodstrom-Tullberg, Malin, Zaitseva, Irina I., Berggren, Per-Olof   +5 more
core   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The Effects of Cytokine Signaling and Memory Differentiation on Mammalian T-helper Cell Effector Phenotype Plasticity

, 2020
T-helper (Th) cells polarize towards different effector phenotypes, including Type 1 and Type 2, which coordinate the defense against different classes of pathogens.
Heilbronner, Alison
core   +2 more sources

Study on the Mechanism of UMI-77 in the Treatment of Sepsis-Induced Acute Lung Injury Based on Transcriptomics and Metabolomics

Journal of Inflammation Research
Jiatian Zhang,1,* Zhelin Xia,2,* Cuicui Dong,3 Jiaqi Zhu,3 Hang Ni,1 Yubin Xu,2,* Yinghe Xu4,* 1Department of Critical Care Medicine, Taizhou Hospital of Zhejiang Province, Shaoxing University, Shaoxing, 312000, People’s Republic of China;
Zhang J, Xia Z, Dong C, Zhu J, Ni H, Xu Y, Xu Y   +6 more
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