Results 1 to 10 of about 28,369,893 (296)

Human interferon-ω: an underappreciated type I interferon [PDF]

Frontiers in Immunology
Interferon-ω (IFN-ω) is a member of the human type I interferon family that has historically been overshadowed by IFN-α and IFN-β. Recent human “natural perturbations”, most notably selective neutralization of IFN-ω by autoantibodies in life-threatening ...
Ruyue Chen
doaj   +2 more sources

Evasion of Type I Interferon by SARS-CoV-2

Cell Reports, 2020
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening
Hongjie Xia, Zengguo Cao, Xuping Xie, Xianwen Zhang, John Yun-Chung Chen, Hualei Wang, Vineet D. Menachery, Ricardo Rajsbaum, Pei-Yong Shi   +8 more
doaj   +2 more sources

Helicobacter pylori-induced immune priming requires type I interferon signaling [PDF]

Frontiers in Immunology
Helicobacter pylori (H. pylori) infection induces persistent colonization and chronic inflammation, yet the mechanisms by which bacterial exposure establishes sustained inflammatory responses remain incompletely understood.
Zhigang Rao, Zhigang Rao, Christof Regl, Christof Regl, Theresa Neuper, Theresa Neuper, Theresa Neuper, Hieu-Hoa Dang, Hieu-Hoa Dang, Gunda Ueblagger, Gunda Ueblagger, Andreas Völkerer, Andreas Völkerer, Christian G. Huber, Christian G. Huber, Jutta Horejs-Hoeck, Jutta Horejs-Hoeck, Jutta Horejs-Hoeck   +17 more
doaj   +2 more sources

Type I interferon in psoriasis: mechanisms and clinical implications [PDF]

Frontiers in Immunology
Psoriasis is a chronic, recurrent, immune-mediated inflammatory skin disease in which the TNF/IL-23/IL-17 axis plays a central role in the maintenance of mature plaques.
Chang Liu, Yidan Zhang, Xiaoqian Cui, Hailong Zhang, Jia Chen, Xiongwei Lian, Suqing Yang   +6 more
doaj   +2 more sources

Cloning of human Type I interferon cDNAs

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2023
In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients.
Shigekazu NAGATA
doaj   +1 more source

Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction

Viruses, 2021
Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis, Ben Jackson, Kay Childs, Mark Boyce, Stephen Goodbourn, Neil Blake, Miren Iturriza-Gomara, Julian Seago   +7 more
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Insights Into Type I and III Interferons in Asthma and Exacerbations

Frontiers in Immunology, 2020
Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich, Danielle Antos, Natalie R. Melton, John F. Alcorn, Michelle L. Manni   +4 more
doaj   +1 more source

Type I interferon: potential therapeutic target for psoriasis? [PDF]

PLoS ONE, 2008
BACKGROUND: Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation.
Yihong Yao, Laura Richman, Chris Morehouse, Melissa de los Reyes, Brandon W Higgs, Anmarie Boutrin, Barbara White, Anthony Coyle, James Krueger, Peter A Kiener, Bahija Jallal   +10 more
doaj   +1 more source

The Role of Interferons in the Pathogenesis of Sjögren’s Syndrome and Future Therapeutic Perspectives

Biomolecules, 2021
There is a great deal of evidence pointing to interferons (IFNs) as being key cytokines in the pathogenesis of different systemic autoimmune diseases, including primary Sjögren’s syndrome (pSS).
Nicoletta Del Papa, Antonina Minniti, Maurizio Lorini, Vincenzo Carbonelli, Wanda Maglione, Francesca Pignataro, Nicola Montano, Roberto Caporali, Claudio Vitali   +8 more
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Antiproliferative Properties of Type I and Type II Interferon

Pharmaceuticals, 2010
The clinical possibilities of interferon (IFN) became apparent with early studies demonstrating that it was capable of inhibiting tumor cells in culture and in vivo using animal models.
Joseph Bekisz, Samuel Baron, Corey Balinsky, Angel Morrow, Kathryn C. Zoon   +4 more
doaj   +1 more source