Results 11 to 20 of about 519,719 (306)
Bunyaviruses and the Type I Interferon System [PDF]
Viruses, 2009 The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott, Friedemann Weber
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Phleboviruses and the Type I Interferon Response [PDF]
Viruses, 2016 The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly ...
Jennifer Deborah Wuerth +1 more
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Cytotoxic lymphocytes counteract viral type I interferon immune evasion. [PDF]
PLoS PathogensViruses are recognized by host cell innate immunity through viral RNA/DNA sensing by cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING). However, many viruses evade cGAS-STING signaling and antiviral IFN-β response.
Michael Y Schakelaar +10 more
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Antiproliferative Properties of Type I and Type II Interferon [PDF]
Pharmaceuticals, 2010 The clinical possibilities of interferon (IFN) became apparent with early studies demonstrating that it was capable of inhibiting tumor cells in culture and in vivo using animal models.
Joseph Bekisz +4 more
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Context-dependent impact of type I interferon signaling in cancer [PDF]
Molecular CancerType I interferon (IFN) has long been known as a critical component of the molecular machinery that first responds to viral infection in multicellular eukaryotes.
Ainhoa Ruiz-Iglesias +3 more
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Type I Interferon in Human Autoimmunity [PDF]
Frontiers in Immunology, 2014 The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease. Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response ...
Timothy B. Niewold
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TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma [PDF]
, 2013 Defective Rhinovirus induced interferon-β and interferon-λ production has been reported in bronchial epithelial cells from asthmatics but the mechanisms of defective interferon induction in asthma are unknown.
Del Rosario, A +8 more
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Immunological Reviews, 2023 SummaryType I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant transformation, tumor progression, and response to therapy. On the one hand, robust, acute, and resolving type I IFN responses have been shown to mediate prominent anticancer effects, reflecting not only their direct cytostatic/cytotoxic activity on (at
Peter Holicek +6 more
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Cloning of human Type I interferon cDNAs
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2023 In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients.
Shigekazu NAGATA
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Type I Interferons in NeuroHIV [PDF]
Viral Immunology, 2019 Infection with Human Immunodeficiency Virus (HIV)-1 continues to cause HIV-associated neurocognitive disorders despite combined antiretroviral therapy. Interferons (IFNs) are important for any antiviral immune response, but the lasting production of IFNα causes exhaustive activation leading eventually to progression to AIDS.
Thaney, Victoria E, Kaul, Marcus
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