Results 41 to 50 of about 521,269 (357)

Fine-Tuning of Type I Interferon Response by STAT3

Frontiers in Immunology, 2019
Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation.
Ming-Hsun Tsai, Li-Mei Pai, Li-Mei Pai, Li-Mei Pai, Chien-Kuo Lee   +4 more
doaj   +1 more source

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection [PDF]

, 2012
The innate immune response provides the first line of defense against viruses and other pathogens by responding to specific microbial molecules. Influenza A virus (IAV) produces double-stranded RNA as an intermediate during the replication life cycle ...
Maelfait, Jonathan, Roose, Kenny, Bogaert, Pieter, Sze, Mozes, Saelens, Xavier, Pasparakis, Manolis, Carpentier, Isabelle, van Loo, Geert, Beyaert, Rudi   +8 more
core   +2 more sources

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 [PDF]

, 2011
The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of viruses replicating in the cytoplasm of eukayotes have evolved 2'-O-methyltransferases to modify autonomously their mRNAs.
A Ghosh, A Nomoto, A Pichlmair, AM Waterhouse, B Morin, Benjamin W Neuman, BS Schnierle, Burkhard Ludewig, CA Janeway Jr., DJ Hui, E Decroly, EJ Snijder, F Terenzi, G Bocharov, G Uzé, H Hemmi, H Kato, H Zhou, J Reguera, JK Roth-Cross, John Ziebuhr, K Bryson, K Karikó, KK Eriksson, KM Rose, Kristy J Szretter, L Cervantes-Barragan, L Cervantes-Barragán, L Gitlin, Luisa Cervantes-Barragan, M Bouvet, M Feder, M Schlee, Matthias Habjan, Michael S Diamond, O Haller, O Le Gall, O Takeuchi, R Gosert, R Züst, Reinhard Maier, Roland Züst, S Daffis, S Shuman, S Wünschmann, SR Nallagatla, SR Nallagatla, Stuart G Siddell, Susan C Baker, V Hornung, V Thiel, Volker Thiel, Winfried Barchet, Y Chen, YM Loo, YM Loo   +55 more
core   +1 more source

The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. [PDF]

PLoS Pathogens, 2011
Gammaherpesviruses such as KSHV and EBV establish lifelong persistent infections through latency in lymphocytes. These viruses have evolved several strategies to counteract the various components of the innate and adaptive immune systems. We conducted an
Ronika Sitapara Leang, Ting-Ting Wu, Seungmin Hwang, Lidia T Liang, Leming Tong, Jennifer T Truong, Ren Sun   +6 more
doaj   +1 more source

Type I interferon-dependent and -independent signaling underlie autoantibody production in a murine lupus model. [PDF]

J Transl Autoimmun
Levine JS, Pilon C, Subang R, Salem D, Lonina E, Qureshi ST, Fonseca GJ, Gros P, Rauch J.   +8 more
europepmc   +2 more sources

Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction [PDF]

, 2012
This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD ...
Childs, Kay, Goodbourn, Stephen, Randall, Richard   +2 more
core   +1 more source

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

Type I Interferons in Host Defense [PDF]

Immunity, 2006
Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to viruses and other intracellular infections. In the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of type I IFNs have been identified and characterized.
Stetson, Daniel B., Medzhitov, Ruslan
openaire   +2 more sources

Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells [PDF]

, 2008
The objective of this study was to investigate the impact of cigarette smoke on innate antiviral defense mechanisms; specifically, we examined the effects of cigarette smoke on the induction of type I interferon (IFN).
Bauer, Carla M.T., DeWitte-Orr, Stephanie J., Hornby, Kyle R., Lichty, Brian D., Mossman, Karen L., Stämpfli, Martin R., Zavitz, Caleb C.J.   +6 more
core   +2 more sources

Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil [PDF]

, 2016
Background: The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern.
Biek, Roman, Brennan, Benjamin, Clark, Jordan J., Cordeiro, Marli T., Cumberworth, Stephanie L., Da Silva Filipe, Ana, Davis, Christopher, Donald, Claire L., Fall, Gamou, Freitas de Oliveira França, Rafael, Hughes, Joseph, Kohl, Alain, Lindenbach, Brett D., McLauchlan, John, Owsianka, Anna M., Patel, Arvind H., Pena, Lindomar J., Rehwinkel, Jan, Rezelj, Veronica V., Sall, Amadou A., Schnettler, Esther, Selinger, Martin, Varjak, Margus, Wilkie, Gavin S., Zuvanov, Luíza   +24 more
core   +3 more sources