Results 41 to 50 of about 28,369,893 (296)
Fine-Tuning of Type I Interferon Response by STAT3
Frontiers in Immunology, 2019 Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation.
Ming-Hsun Tsai +4 more
doaj +1 more source
Interfering with interferon: developing a reporter system to study the interaction between hepatitus C viral proteins and the interferon signalling pathway [PDF]
, 2008 PhDThe aim of the project was to investigate the mechanism by which HCV evades therapeutic IFN treatment. This involved the development of novel testing systems and their application to patient samples.
Jones, Meleri
core +2 more sources
Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]
, 2013 Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Heiko Mühl, Heiko eMühl, Mühl, Heiko
core +1 more source
Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
Frontiers in Immunology, 2020 Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs). The
Megan L. Stanifer +4 more
doaj +1 more source
Immunomodulatory functions of type I interferons [PDF]
Nature Reviews Immunology, 2012 Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, indicating a broader physiological role for these ...
González Navajas, José Manuel +3 more
openaire +3 more sources
Effects of type I interferons in malaria [PDF]
Immunology, 2018 SummaryType I interferons (IFNs) are a family of cytokines with a wide range of biological activities including anti‐viral and immune‐regulatory functions. Here, we focus on the protozoan parasitic disease malaria, and examine the effects of type I IFN‐signalling during Plasmodium infection of humans and experimental mice.
Ismail Sebina, Ashraful Haque
openaire +5 more sources
The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. [PDF]
PLoS Pathogens, 2011 Gammaherpesviruses such as KSHV and EBV establish lifelong persistent infections through latency in lymphocytes. These viruses have evolved several strategies to counteract the various components of the innate and adaptive immune systems. We conducted an
Ronika Sitapara Leang +6 more
doaj +1 more source
Interferon-producing cells are enriched for defective influenza segments.
, 2021 (A) Differential gene expression analysis on interferon-enriched and -depleted populations. An A549 type I interferon reporter cell line was infected at an MOI of 0.1 and sorted using magnetic-activated cell sorting 14 hours post infection.
Marisa Mendes (11820361) +1 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Signal Transduction by Type I Interferons [PDF]
BioTechniques, 2002 The two classes of interferons, type I (IFNalpha, IFNbeta, IFNomega, and IFNtau) and type II (IFNgamma) are pleiotropic cytokines that exhibit antiviral, antiproliferative, and immunomodulatory effects on their target cells. This article summarizes the advances made in elucidating the molecular events that mediate the biological responses to type I ...
openaire +3 more sources