Results 41 to 50 of about 26,674,548 (252)

Fine-Tuning of Type I Interferon Response by STAT3

Frontiers in Immunology, 2019
Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation.
Ming-Hsun Tsai, Li-Mei Pai, Li-Mei Pai, Li-Mei Pai, Chien-Kuo Lee   +4 more
doaj   +1 more source

Immunomodulatory functions of type I interferons [PDF]

Nature Reviews Immunology, 2012
Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, indicating a broader physiological role for these ...
González Navajas, José Manuel, Lee, Jongdae, David, Michael, Raz, Eyal   +3 more
openaire   +3 more sources

The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. [PDF]

PLoS Pathogens, 2011
Gammaherpesviruses such as KSHV and EBV establish lifelong persistent infections through latency in lymphocytes. These viruses have evolved several strategies to counteract the various components of the innate and adaptive immune systems. We conducted an
Ronika Sitapara Leang, Ting-Ting Wu, Seungmin Hwang, Lidia T Liang, Leming Tong, Jennifer T Truong, Ren Sun   +6 more
doaj   +1 more source

Effects of type I interferons in malaria [PDF]

Immunology, 2018
SummaryType I interferons (IFNs) are a family of cytokines with a wide range of biological activities including anti‐viral and immune‐regulatory functions. Here, we focus on the protozoan parasitic disease malaria, and examine the effects of type I IFN‐signalling during Plasmodium infection of humans and experimental mice.
Ismail Sebina, Ashraful Haque
openaire   +5 more sources

Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection [PDF]

, 2013
Background & Aims: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most powerful predictors for sustained virologic response (SVR) in patients with chronic hepatitis C virus (HCV) infection, compared to other biochemical or ...
Simone Susser (48294), Annika Brodzinski, Thomas Berg (186372), Migaud, Pascal, Jacob George (205614), Brodzinski, Annika, Tobias Müller, Susser, Simone, Stephan Böhm (334611), Sarrazin, Christoph, Christoph Sarrazin (48298), Pascal Migaud, Schott, Eckart, Bömmel, Florian van, Heiko Witt, Florian van Bömmel, Janett Fischer, Christoph Sarrazin, Stewart, Graeme, Graeme Stewart, Witt, Heiko, Thomas Berg, Simone Susser, Balazs Fülöp, Fülöp, Balazs, Stephan Böhm, Annika Brodzinski (477753), Balazs Fülöp (477754), Müller, Tobias, Fischer, Janett, Böhm, Stephan, Berg, Thomas, Tobias Müller (163591), Janett Fischer (477751), Eckart Schott (320945), Graeme Stewart (208243), Jacob George, Heiko Witt (161481), Pascal Migaud (477752), George, Jacob, Eckart Schott, Florian van Bömmel (477755)   +41 more
core   +1 more source

Regulation of type I interferon responses [PDF]

Nature Reviews Immunology, 2013
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs).
Lionel B, Ivashkiv, Laura T, Donlin
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Signal Transduction by Type I Interferons [PDF]

BioTechniques, 2002
The two classes of interferons, type I (IFNalpha, IFNbeta, IFNomega, and IFNtau) and type II (IFNgamma) are pleiotropic cytokines that exhibit antiviral, antiproliferative, and immunomodulatory effects on their target cells. This article summarizes the advances made in elucidating the molecular events that mediate the biological responses to type I ...
openaire   +3 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Human interferon-ω: an underappreciated type I interferon

Frontiers in Immunology
Interferon-ω (IFN-ω) is a member of the human type I interferon family that has historically been overshadowed by IFN-α and IFN-β. Recent human “natural perturbations”, most notably selective neutralization of IFN-ω by autoantibodies in life-threatening ...
Ruyue Chen
doaj   +1 more source