Results 21 to 30 of about 26,674,548 (252)

Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes

Frontiers in Immunology, 2021
Type I interferons (IFN-I) were first discovered as an antiviral factor by Isaacs and Lindenmann in 1957, but they are now known to also modulate innate and adaptive immunity and suppress proliferation of cancer cells.
Megen C. Wittling, Shannon R. Cahalan, Eric A. Levenson, Ronald L. Rabin   +3 more
doaj   +1 more source

Loss of Ifnar1 in Pancreatic Acinar Cells Ameliorates the Disease Course of Acute Pancreatitis. [PDF]

PLoS ONE, 2015
Type I interferon constitutes an essential component of the combinational therapy against viral disease. Acute pancreatitis is one side effect of type I interferon-based therapy, implying that activation of type I interferon signaling affects the ...
Katharina J Miller, Susanne Raulefs, Bo Kong, Katja Steiger, Ivonne Regel, Andreas Gewies, Jörg Kleeff, Christoph W Michalski   +7 more
doaj   +1 more source

Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. [PDF]

PLoS ONE, 2014
The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease ...
Daniel P Beiting, Lucia Peixoto, Natalia S Akopyants, Stephen M Beverley, E John Wherry, David A Christian, Christopher A Hunter, Igor E Brodsky, David S Roos   +8 more
doaj   +1 more source

Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis [PDF]

, 2012
Contains fulltext : 108027.pdf (Publisher’s version ) (Open Access)Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains the leading cause of mortality from a single infectious agent.
Crevel, R. van, van Crevel, R., Hazel E E Wong, Sahiratmadja Edhyana, Zhang, M.M., Wong, Hazel EE, Ottenhoff, THM, van de Vosse, Esther, Yang, N., Ottenhoff, T.H., Martin L Hibberd, Ottenhoff Tom H. M., Khor C.C., Dass, Ranjeeta, Reinout van Crevel, Hibberd M.L., van Crevel Reinout, Dass R.H., Yang, N, Chiea Chuen Khor, Khor, C.C., Seielstad, M., Zhang Mingzi M., van de Vosse E., Zhang M.M., Ottenhoff, Tom HM, Tom H M Ottenhoff, van Crevel, Reinout, Ottenhoff, T.H.M., Yang, Ninghan, Sahiratmadja, Edhyana, Wong, H.E., Seielstad M., Sahiratmadja E., Alisjahbana Bachti, Marzuki, Sangkot, van Crevel R., Khor, CC, Edhyana Sahiratmadja, Bachti Alisjahbana, Yang Ninghan, Alisjahbana, B., Hibberd, M.L., Ninghan Yang, Alisjahbana, Bachti, van, R, van de Vosse, E., Wong, Hazel, Dass Ranjeeta Hari, Alisjahbana, B, Ranjeeta Hari Dass, Hibberd, Martin, Yang, N.H., Sangkot Marzuki, Dass, Ranjeeta Hari, Seielstad Mark, Khor Chiea Chuen, Ottenhoff, Tom, Marzuki, S., Dass, RH, Hibberd Martin L., Marzuki, S, Wong H.E.E., Marzuki S., Zhang, M.Z.M., Zhang, MM, Khor, Chiea, van de Vosse Esther, Khor, Chiea Chuen, Mark Seielstad, Vosse, E. van de, Marzuki Sangkot, Sahiratmadja, E., Dass, R.H., Yang N., Zhang, Mingzi, Seielstad, Mark, Wong, HEE, Hibberd, Martin L, Sahiratmadja, E, Ottenhoff T.H.M., Zhang, Mingzi M, Esther van de Vosse, Alisjahbana B., Wong Hazel E. E., Wong, H.E.E., Mingzi M Zhang   +86 more
core   +3 more sources

Influenza virus activation of the interferon system [PDF]

, 2015
This study was supported by the Wellcome Trust (grant number 087751/A/08/Z) and the Medical Research Council (grant number G0700848).The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to ...
Fodor, Ervin, Killip, Marian J., Randall, RE, Fodor, E., Killip, MJ, Randall, Richard E., Fodor, E, Killip, M.J., Randall, R.E.   +8 more
core   +1 more source

Type I interferon induces cancer stem cells-mediated chemotherapy resistance

OncoImmunology, 2022
In a recent study in Nature Immunology, Musella et al. demonstrate that suboptimal type I interferon (IFN-I) signaling in tumors undergoing immunogenic cell death (ICD) facilitates the accumulation of cancer stem cells (CSCs) by triggering the epigenetic
Mara De Martino, Claire Vanpouille-Box
doaj   +1 more source

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response [PDF]

, 2009
The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates
Fragkoudis, R., Kohl, A., Rodriguez-Andres, J., Kohl, Alain, Breakwell, L, Barry, G, Fazakerley, J.K., Breakwell, Lucy, Attarzadeh-Yazdi, G., Kohl, A, Barry, Gerald, Fazakerley, John K, Attarzadeh-Yazdi, G, Fazakerley, JK, Fragkoudis, R, Barry, G., Attarzadeh-Yazdi, Ghassem, Rodriguez-Andres, J, Breakwell, L., Rodriguez-Andres, Julio, Fragkoudis, Rennos   +20 more
core   +1 more source

Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]

, 2009
Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul, Johannsen, Eric, Haas, Juergen, Hyun Joo, Chul, Fossum, Even, Hutt-Fletcher, Lindsay M., Wu, L., Inn, Kyung-Soo, Jung, Jae U.   +8 more
core   +1 more source

Type I Interferon Induction in Cutaneous DNA Damage Syndromes

Frontiers in Immunology, 2021
Type I interferons (IFNs) as part of the innate immune system have an outstanding importance as antiviral defense cytokines that stimulate innate and adaptive immune responses.
Benjamin Klein, Claudia Günther
doaj   +1 more source

Antagonism of type I interferon by flaviviruses [PDF]

Biochemical and Biophysical Research Communications, 2017
The prompt and tightly controlled induction of type I interferon is a central event of the immune defense against viral infection. Flaviviruses comprise a large family of arthropod-borne positive-stranded RNA viruses, many of which represent a serious threat to global human health due to their high rates of morbidity and mortality.
Lisa, Miorin, Ana M, Maestre, Ana, Fernandez-Sesma, Adolfo, García-Sastre   +3 more
openaire   +2 more sources