Results 31 to 40 of about 28,369,893 (296)
Antagonism of type I interferon by flaviviruses [PDF]
Biochemical and Biophysical Research Communications, 2017 The prompt and tightly controlled induction of type I interferon is a central event of the immune defense against viral infection. Flaviviruses comprise a large family of arthropod-borne positive-stranded RNA viruses, many of which represent a serious threat to global human health due to their high rates of morbidity and mortality.
Lisa, Miorin +3 more
openaire +2 more sources
An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response [PDF]
, 2014 Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, IFN-dependent upregulation of IFN-stimulated genes (ISGs) and the activity of various ...
Fernández, Yolanda +24 more
core +1 more source
Hantavirus Regulation of Type I Interferon Responses
Advances in Virology, 2012 Hantaviruses primarily infect human endothelial cells (ECs) and cause two highly lethal human diseases. Early addition of Type I interferon (IFN) to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to prevent early ...
Valery Matthys, Erich R. Mackow
doaj +1 more source
Viruses, 2012 Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules,
Xiuqing Wang, Jane Christopher-Hennings
doaj +1 more source
Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo
Pathogens, 2022 Gammaherpesviruses, such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, are important human pathogens involved in lymphoproliferative disorders and tumorigenesis.
Johannes Schwerk +14 more
doaj +1 more source
Interferon signalling in the liver : implications for the natural course and therapy of hepatitis C [PDF]
, 2012 Hepatitis C virus is a global health concern, estimated to infect 2-3% of the world's population. Inter-individual differences in the course of infection and response to therapy, highlighted by recent genomewide association studies, point to the crucial ...
Makowska, Zuzanna
core +1 more source
Tick-Borne Flaviviruses and the Type I Interferon Response
Viruses, 2018 Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes.
Richard Lindqvist +2 more
doaj +1 more source
Type I interferon, anti-interferon antibodies, and COVID-19 [PDF]
The Lancet Rheumatology, 2021 Author(s): Calabrese, Leonard H; Winthrop, Kevin; Strand, Vibeke; Yazdany, Jinoos; Walter, Jolan ...
Calabrese, Leonard H +4 more
openaire +4 more sources
The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant [PDF]
, 2013 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials.
Cevayir Coban +35 more
core +1 more source
The human immune response to tuberculosis and its treatment: a view from the blood. [PDF]
, 2015 The immune response upon infection with the pathogen Mycobacterium tuberculosis is poorly understood, hampering the discovery of new treatments and the improvements in diagnosis.
van Helden, Paul +9 more
core +1 more source