Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo
Pathogens, 2022 Gammaherpesviruses, such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, are important human pathogens involved in lymphoproliferative disorders and tumorigenesis.
Johannes Schwerk +14 more
doaj +1 more source
Type I/II interferon in HIV-1-infected patients: expression in gut mucosa and in peripheral blood mononuclear cells and its modification upon probiotic supplementation [PDF]
, 2018 Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic ...
Antonelli, Guido +10 more
core +1 more source
Hantavirus Regulation of Type I Interferon Responses
Advances in Virology, 2012 Hantaviruses primarily infect human endothelial cells (ECs) and cause two highly lethal human diseases. Early addition of Type I interferon (IFN) to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to prevent early ...
Valery Matthys, Erich R. Mackow
doaj +1 more source
Viruses, 2012 Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules,
Xiuqing Wang, Jane Christopher-Hennings
doaj +1 more source
An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response. [PDF]
, 2014 Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, interferon (IFN)-dependent upregulation of IFN-stimulated genes (ISGs), and the activity
Asensio, VJ +7 more
core +2 more sources
Type I interferon in rheumatic diseases [PDF]
Nature Reviews Rheumatology, 2018 The type I interferon pathway has been implicated in the pathogenesis of a number of rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis, systemic sclerosis, and rheumatoid arthritis. In normal immune responses, type I interferons have a critical role in the defence against viruses, yet in many rheumatic diseases ...
Theresa L Wampler, Muskardin +1 more
openaire +2 more sources
Peripheral inflammation is associated with remote global gene expression changes in the brain [PDF]
, 2014 Background: Although the central nervous system (CNS) was once considered an immunologically privileged site, in recent years it has become increasingly evident that cross talk between the immune system and the CNS does occur. As a result, patients with
Cavanagh, Jonathan +3 more
core +2 more sources
Tick-Borne Flaviviruses and the Type I Interferon Response
Viruses, 2018 Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes.
Richard Lindqvist +2 more
doaj +1 more source
Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]
, 2013 Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core +5 more sources
A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages [PDF]
, 2017 Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded ...
Akira +67 more
core +3 more sources