Loss of Ifnar1 in Pancreatic Acinar Cells Ameliorates the Disease Course of Acute Pancreatitis. [PDF]
PLoS ONE, 2015 Type I interferon constitutes an essential component of the combinational therapy against viral disease. Acute pancreatitis is one side effect of type I interferon-based therapy, implying that activation of type I interferon signaling affects the ...
Katharina J Miller +7 more
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Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes
Frontiers in Immunology, 2021 Type I interferons (IFN-I) were first discovered as an antiviral factor by Isaacs and Lindenmann in 1957, but they are now known to also modulate innate and adaptive immunity and suppress proliferation of cancer cells.
Megen C. Wittling +3 more
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Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. [PDF]
PLoS ONE, 2014 The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease ...
Daniel P Beiting +8 more
doaj +1 more source
STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]
, 2013 UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R +6 more
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Antagonism of type I interferon by flaviviruses [PDF]
Biochemical and Biophysical Research Communications, 2017 The prompt and tightly controlled induction of type I interferon is a central event of the immune defense against viral infection. Flaviviruses comprise a large family of arthropod-borne positive-stranded RNA viruses, many of which represent a serious threat to global human health due to their high rates of morbidity and mortality.
Lisa, Miorin +3 more
openaire +2 more sources
Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]
, 2013 Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core +5 more sources
EHMT1 Protein Binds to Nuclear Factor-κB p50 and Represses Gene Expression [PDF]
, 2012 Transcriptional homeostasis relies on the balance between positive and negative regulation of gene transcription. Methylation of histone H3 lysine 9 (H3K9) is commonly correlated with gene repression.
Baltimore, David +3 more
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Type I interferons in infectious disease [PDF]
Nature Reviews Immunology, 2015 Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction of other mediators. Type I IFNs are important for host defence against viruses.
Finlay McNab +4 more
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Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction [PDF]
, 2012 This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD ...
Childs, Kay +2 more
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Type I interferon, anti-interferon antibodies, and COVID-19 [PDF]
The Lancet Rheumatology, 2021 Author(s): Calabrese, Leonard H; Winthrop, Kevin; Strand, Vibeke; Yazdany, Jinoos; Walter, Jolan ...
Calabrese, Leonard H +4 more
openaire +4 more sources