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Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction [PDF]

Viruses, 2021
Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis, Ben Jackson, Kay Childs, Mark Boyce, Stephen Goodbourn, Neil Blake, Miren Iturriza-Gomara, Julian Seago   +7 more
doaj   +5 more sources

Insights Into Type I and III Interferons in Asthma and Exacerbations [PDF]

Frontiers in Immunology, 2020
Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich, Danielle Antos, Natalie R. Melton, John F. Alcorn, Michelle L. Manni   +4 more
doaj   +3 more sources

Pseudorabies virus-induced expression and antiviral activity of type I or type III interferon depend on the type of infected epithelial cell

Frontiers in Immunology, 2022
Type I and III Interferons (IFNs) are the initial antiviral cytokines produced in response to virus infection. These IFNs in turn bind to their respective receptors, trigger JAK-STAT signaling and induce the expression of IFN-stimulated genes (ISGs) to ...
Yue Yin, Jinglin Ma, Cliff Van Waesberghe, Bert Devriendt, Herman W. Favoreel   +4 more
doaj   +3 more sources

Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs

Frontiers in Immunology, 2017
Type III interferons (IFNs) (or IFN-λ) are the latest addition to the IFN family. Even though they share little protein homology with type I IFN, both exhibit remarkable functional similarities: each can be induced in response to viral infections, and ...
Ivan Zanoni, Ivan Zanoni, Francesca Granucci, Achille Broggi   +3 more
doaj   +3 more sources

Type III interferon exerts thymic stromal lymphopoietin in mediating adaptive antiviral immune response

Frontiers in Immunology, 2023
Previously, it was believed that type III interferon (IFN-III) has functions similar to those of type I interferon (IFN-I). However, recently, emerging findings have increasingly indicated the non-redundant role of IFN-III in innate antiviral immune ...
Luhong Cao, Weiwei Qian, Wanlin Li, Zhiyue Ma, Shenglong Xie   +4 more
doaj   +3 more sources

Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1

Frontiers in Immunology, 2021
Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections.
Tamiris Azamor, Tamiris Azamor, Daniela Prado Cunha, Andréa Marques Vieira da Silva, Ohanna Cavalcanti de Lima Bezerra, Marcelo Ribeiro-Alves, Thyago Leal Calvo, Fernanda de Souza Gomes Kehdy, Fernanda Saloum de Neves Manta, Thiago Gomes de Toledo Pinto, Laís Pereira Ferreira, Elyzabeth Avvad Portari, Letícia da Cunha Guida, Leonardo Gomes, Maria Elisabeth Lopes Moreira, Elizeu Fagundes de Carvalho, Cynthia Chester Cardoso, Marcelo Muller, Ana Paula Dinis Ano Bom, Patrícia Cristina da Costa Neves, Zilton Vasconcelos, Milton Ozório Moraes   +21 more
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Sarbecovirus ORF6 proteins hamper induction of interferon signaling

Cell Reports, 2021
Summary: The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses.
Izumi Kimura, Yoriyuki Konno, Keiya Uriu, Kristina Hopfensperger, Daniel Sauter, So Nakagawa, Kei Sato   +6 more
doaj   +1 more source

Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces

Frontiers in Immunology, 2020
Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs). The
Megan L. Stanifer, Cuncai Guo, Patricio Doldan, Steeve Boulant, Steeve Boulant   +4 more
doaj   +1 more source

Photochemotherapy Induces Interferon Type III Expression via STING Pathway

Cells, 2020
DNA-damaging cancer therapies induce interferon expression and stimulate the immune system, promoting therapy responses. The immune-activating STING (Stimulator of Interferon Genes) pathway is induced when DNA or double-stranded RNA (dsRNA) is detected ...
Edyta Biskup, Brian Daniel Larsen, Leonor Rib, Lasse Folkersen, Omid Niazi, Maria R. Kamstrup, Claus Storgaard Sørensen   +6 more
doaj   +1 more source

The Role of Structure in the Biology of Interferon Signaling

Frontiers in Immunology, 2020
Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic programs that enhance resistance to viral infection. Induction of an antiviral state at the cell, tissue, organ, and organismal level is performed by three ...
Mark R. Walter
doaj   +1 more source