Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction [PDF]
Viruses, 2021 Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis +7 more
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Type III interferon drives pathogenicity to Staphylococcus aureus via the airway epithelium [PDF]
mBioType III interferon signaling contributes to the pathogenesis of the important human pathogen Staphylococcus aureus in the airway. Little is known of the cellular factors important in this response.
Silvia Pires +2 more
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Differential Regulation of Type I and Type III Interferon Signaling [PDF]
International Journal of Molecular Sciences, 2019 Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I,
Kalliopi Pervolaraki +2 more
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Type III interferon exerts thymic stromal lymphopoietin in mediating adaptive antiviral immune response [PDF]
Frontiers in Immunology, 2023 Previously, it was believed that type III interferon (IFN-III) has functions similar to those of type I interferon (IFN-I). However, recently, emerging findings have increasingly indicated the non-redundant role of IFN-III in innate antiviral immune ...
Luhong Cao +4 more
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HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon [PDF]
Cell Reports, 2020 Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes simplex virus 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea.
Pallavi Chandra +2 more
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The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis [PDF]
Frontiers in Microbiology, 2020 Porcine epidemic diarrhea virus (PEDV) is an economically important pathogen that has evolved several mechanisms to evade type I IFN responses. Type III interferon (IFN-λ), an innate cytokine that primarily targets the mucosal epithelia, is critical in ...
Changlin Wang +10 more
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Inhibition of Type III Interferon Expression in Intestinal Epithelial Cells—A Strategy Used by Coxsackie B Virus to Evade the Host’s Innate Immune Response at the Primary Site of Infection? [PDF]
Microorganisms, 2021 Increasing evidence highlights the importance of the antiviral activities of the type III interferons (IFNλs; IL-28A, IL-28B, IL29, and IFNλ4) in the intestine.
Virginia M. Stone +6 more
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Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus. [PDF]
Gut Microbes, 2023 Cryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor settings. The majority of infections are caused by the human-specific pathogen C.
Greigert V +10 more
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Type III interferon drives thymic B cell activation and regulatory T cell generation. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance B cells are an important antigen presenting cell subset in the thymus that require activation to mediate T cell central tolerance. The process of thymic B cell activation, termed licensing, results in isotype class-switch recombination and ...
Martinez RJ +9 more
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SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas. [PDF]
Cell Host Microbe, 2023 SUMMARY Hemochorial placentas have evolved defense mechanisms to prevent vertical transmission of viruses to the immunologically underdeveloped fetus.
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