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Guarding the frontiers: the biology of type III interferons [PDF]
Nature Immunology, 2015 Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier tissues. IFN-λs thereby help to maintain healthy mucosal surfaces through immune protection, without
Andreas Wack +2 more
openaire +4 more sources
Regulation of apoptosis by type III interferons [PDF]
Cell Proliferation, 2008 Abstract. Objective: Two types of interferons (IFNs), type I (IFN‐α/β) and type III (IFN‐λs), utilize distinct receptor complexes to induce similar signalling and biological activities, including recently demonstrated for IFN‐λs antitumour activity. However, ability of type III IFNs to regulate cell population growth remains largely uncharacterized ...
W, Li +4 more
openaire +2 more sources
Sarbecovirus ORF6 proteins hamper induction of interferon signaling
Cell Reports, 2021 Summary: The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses.
Izumi Kimura +6 more
doaj +1 more source
The Role of Type III Interferons in Human Disease
Clinical and Investigative Medicine, 2021 Purpose This literature review summarizes the main immunological characteristics of type III interferons (IFN) and highlights the clinically relevant aspects and future therapeutic perspectives for these inflammatory molecules. Source Relevant articles in PubMed MEDLINE from the first publication (2003) until 2020.
Malik, Anikó Éva +2 more
openaire +4 more sources
Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
Frontiers in Immunology, 2020 Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs). The
Megan L. Stanifer +4 more
doaj +1 more source
HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon [PDF]
Cell Reports, 2020 Jonathan J Miner +2 more
exaly +2 more sources
Interferon-lambda: A potent regulator of intestinal viral infections [PDF]
, 2017 Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Baldridge, Megan T, Lee, Sanghyun
core +8 more sources
Inhibition of SARS–CoV-2 by type I and type III interferons [PDF]
Journal of Biological Chemistry, 2020 The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested the inhibitory activities of the antiviral interferons of type I (IFN-α) and type III (IFN-λ) against SARS-CoV-2 and compared them with those against SARS-CoV-1, which emerged in ...
Felgenhauer, Ulrike +7 more
openaire +2 more sources
Human interferon-λ3 is a potent member of the type III interferon family [PDF]
Genes & Immunity, 2008 Type III interferon (IFN) or IFN-lambda is a recently discovered family of IFNs that signal through the same downstream transcription factors as type I IFN but use a separate receptor complex composed of the IL-10R2 and the unique IFN-lambdaR1 receptor chains.
Dellgren, C +4 more
openaire +3 more sources
Photochemotherapy Induces Interferon Type III Expression via STING Pathway
Cells, 2020 DNA-damaging cancer therapies induce interferon expression and stimulate the immune system, promoting therapy responses. The immune-activating STING (Stimulator of Interferon Genes) pathway is induced when DNA or double-stranded RNA (dsRNA) is detected ...
Edyta Biskup +6 more
doaj +1 more source