Results 21 to 30 of about 9,940,893 (244)

Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction [PDF]

, 2012
This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD ...
Childs, Kay, Randall, Richard, Goodbourn, Stephen   +2 more
core   +2 more sources

Inhibition of SARS–CoV-2 by type I and type III interferons [PDF]

Journal of Biological Chemistry, 2020
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested the inhibitory activities of the antiviral interferons of type I (IFN-α) and type III (IFN-λ) against SARS-CoV-2 and compared them with those against SARS-CoV-1, which emerged in ...
Felgenhauer, Ulrike, Schoen, Andreas, Gad, Hans Henrik, Hartmann, Rune, Schaubmar, Andreas R., Failing, Klaus, Drosten, Christian, Weber, Friedemann   +7 more
openaire   +2 more sources

Human interferon-λ3 is a potent member of the type III interferon family [PDF]

Genes & Immunity, 2008
Type III interferon (IFN) or IFN-lambda is a recently discovered family of IFNs that signal through the same downstream transcription factors as type I IFN but use a separate receptor complex composed of the IL-10R2 and the unique IFN-lambdaR1 receptor chains.
Dellgren, C, Gad, Hans Henrik; id_orcid 0000-0001-8449-1115, Hamming, O J, Melchjorsen, J, Hartmann, R   +4 more
openaire   +3 more sources

Shared and Distinct Functions of Type I and Type III Interferons [PDF]

Immunity, 2019
Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. However, recent discoveries have revealed context-specific functional differences.
Helen M, Lazear, John W, Schoggins, Michael S, Diamond   +2 more
openaire   +2 more sources

Influenza virus activation of the interferon system [PDF]

, 2015
This study was supported by the Wellcome Trust (grant number 087751/A/08/Z) and the Medical Research Council (grant number G0700848).The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to ...
Fodor, Ervin, Killip, Marian J., Randall, RE, Fodor, E., Killip, MJ, Randall, Richard E., Fodor, E, Killip, M.J., Randall, R.E.   +8 more
core   +1 more source

The regulation of type I interferon production by paramyxoviruses [PDF]

, 2009
Research supported by The Wellcome Trust (087751/A/08/Z)Experimentally, paramyxoviruses are conventionally considered good inducers of type I interferons (IFN-alpha/beta), and have been used as agents in the commercial production of human IFN-alpha ...
Goodbourn, S, Richard E. Randall, Stephen Goodbourn, Randall, Richard Edward   +3 more
core   +1 more source

Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis [PDF]

, 2012
Contains fulltext : 108027.pdf (Publisher’s version ) (Open Access)Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains the leading cause of mortality from a single infectious agent.
Crevel, R. van, van Crevel, R., Hazel E E Wong, Sahiratmadja Edhyana, Zhang, M.M., Wong, Hazel EE, Ottenhoff, THM, van de Vosse, Esther, Yang, N., Ottenhoff, T.H., Martin L Hibberd, Ottenhoff Tom H. M., Khor C.C., Dass, Ranjeeta, Reinout van Crevel, Hibberd M.L., van Crevel Reinout, Dass R.H., Yang, N, Chiea Chuen Khor, Khor, C.C., Seielstad, M., Zhang Mingzi M., van de Vosse E., Zhang M.M., Ottenhoff, Tom HM, Tom H M Ottenhoff, van Crevel, Reinout, Ottenhoff, T.H.M., Yang, Ninghan, Sahiratmadja, Edhyana, Wong, H.E., Seielstad M., Sahiratmadja E., Alisjahbana Bachti, Marzuki, Sangkot, van Crevel R., Khor, CC, Edhyana Sahiratmadja, Bachti Alisjahbana, Yang Ninghan, Alisjahbana, B., Hibberd, M.L., Ninghan Yang, Alisjahbana, Bachti, van, R, van de Vosse, E., Wong, Hazel, Dass Ranjeeta Hari, Alisjahbana, B, Ranjeeta Hari Dass, Hibberd, Martin, Yang, N.H., Sangkot Marzuki, Dass, Ranjeeta Hari, Seielstad Mark, Khor Chiea Chuen, Ottenhoff, Tom, Marzuki, S., Dass, RH, Hibberd Martin L., Marzuki, S, Wong H.E.E., Marzuki S., Zhang, M.Z.M., Zhang, MM, Khor, Chiea, van de Vosse Esther, Khor, Chiea Chuen, Mark Seielstad, Vosse, E. van de, Marzuki Sangkot, Sahiratmadja, E., Dass, R.H., Yang N., Zhang, Mingzi, Seielstad, Mark, Wong, HEE, Hibberd, Martin L, Sahiratmadja, E, Ottenhoff T.H.M., Zhang, Mingzi M, Esther van de Vosse, Alisjahbana B., Wong Hazel E. E., Wong, H.E.E., Mingzi M Zhang   +86 more
core   +3 more sources

Microbial pathogenesis and type III interferons

Cytokine & Growth Factor Reviews, 2016
The innate immune system possesses a multitude of pathways to sense and respond to microbial pathogens. One such family are the interferons (IFNs), a family of cytokines that are involved in several cellular functions. Type I IFNs are appreciated to be important in several viral and bacterial diseases, while the recently identified type III IFNs (IFNL1,
Cohen, Taylor S., Parker, Dane
openaire   +2 more sources

The Capsule of Acinetobacter baumannii Protects against the Innate Immune Response

Journal of Innate Immunity, 2022
Acinetobacter baumannii is an opportunistic pathogen that has recently emerged as a global threat associated with high morbidity, mortality, and antibiotic resistance. We determined the role of type I interferon (IFN) signaling in A. baumannii infection.
Lavoisier Akoolo, Silvia Pires, Jisun Kim, Dane Parker   +3 more
doaj   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source