Antiviral Functions of Type I and Type III Interferons in the Olfactory Epithelium
Biomolecules, 2023 The olfactory neuroepithelium (OE) is one of the few neuronal tissues where environmental pathogens can gain direct access. Despite this vulnerable arrangement, little is known about the protective mechanisms in the OE to prevent viral infection and its ...
Ahmad Zedan +6 more
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Differential type I and type III interferon expression profiles in rheumatoid and juvenile idiopathic arthritis [PDF]
Frontiers in MedicineBackgroundThe role of type I and type III interferons (IFNs) in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) is still poorly understood.
Anikó E. Malik +12 more
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Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. [PDF]
PLoS Pathogens, 2018 It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces.
Kalliopi Pervolaraki +10 more
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Inhibition of Type III Interferon Expression in Intestinal Epithelial Cells—A Strategy Used by Coxsackie B Virus to Evade the Host’s Innate Immune Response at the Primary Site of Infection? [PDF]
Microorganisms, 2021 Increasing evidence highlights the importance of the antiviral activities of the type III interferons (IFNλs; IL-28A, IL-28B, IL29, and IFNλ4) in the intestine.
Virginia M. Stone +6 more
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The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Interferons (IFNs) are secreted proteins of the cytokine family that regulate innate and adaptive immune responses to infection. Although the importance of IFNs in the antiviral response has long been appreciated, their role in bacterial infections is ...
Olivier eDussurget +2 more
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The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis [PDF]
Frontiers in Microbiology, 2020 Porcine epidemic diarrhea virus (PEDV) is an economically important pathogen that has evolved several mechanisms to evade type I IFN responses. Type III interferon (IFN-λ), an innate cytokine that primarily targets the mucosal epithelia, is critical in ...
Changlin Wang +10 more
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Novel Nonviral Bioassays for Mouse Type I and Type III Interferon [PDF]
Journal of Interferon & Cytokine Research, 2011 We used embryo fibroblasts from Mx2-Luc transgenic mice that express Firefly luciferase under control of the interferon (IFN)-regulated mouse Mx2 promoter to develop simple nonviral bioassays for type I and type III IFN. Since type III IFN is acid-labile, Mx2-Luc fibroblasts detected the presence of type I IFN in acid-treated biological samples with ...
Kugel, Daniela +4 more
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Herpesviruses and the Type III Interferon System. [PDF]
Virol Sin, 2021 Type III interferons (IFNs) represent the most recently discovered group of IFNs. Together with type I IFNs (e.g. IFN-α/β), type III IFNs (IFN-λ) are produced as part of the innate immune response to virus infection, and elicit an anti-viral state by inducing expression of interferon stimulated genes (ISGs).
Yin Y, Favoreel HW.
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Type iii interferon for use as a biomarker to predict response to a cancer treatment
, 2021 The present invention relates to type III interferon, alone or in conjunction with Dendritic Cells subtypes markers, for use as a biomarker to predict response to a cancer treatment chosen from immunotherapies, targeted therapies, chemotherapies, and/or ...
Hubert, Margaux +2 more
core +5 more sources
Type I and type III interferon in opposition? [PDF]
Nat Rev Immunol, 2020 Park MD.
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