Results 21 to 30 of about 606,510 (165)

Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2. [PDF]

Nat Commun
Conventional dendritic cell and plasmacytoid dendritic cell (pDC) subsets have specialized functions that can be modulated by the tumor microenvironment, and produce different interferons that are central to antitumor immune responses. While the function
Sakref C, Saby A, Rodriguez C, Ardin M, Moudombi L, Doffin AC, Gobbini E, Voissiere A, Besson L, Laoubi L, Böttcher J, Depil S, Hubert M, Bendriss-Vermare N, Caux C, Valladeau-Guilemond J.   +15 more
europepmc   +2 more sources

Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responses. [PDF]

J Immunother Cancer
Background Interferons (IFNs) are essential for activating an effective immune response and play a central role in immunotherapy-mediated immune cell reactivation for tumor regression.
Wang B, Zhou B, Chen J, Sun X, Yang W, Yang T, Yu H, Chen P, Chen K, Huang X, Fan X, He W, Huang J, Lin T.   +13 more
europepmc   +2 more sources

Enterovirus 71 Antagonizes Antiviral Effects of Type III Interferon and Evades the Clearance of Intestinal Intraepithelial Lymphocytes. [PDF]

Front Microbiol, 2021
Enterovirus 71 (EV71) is the major pathogen causing severe neurological complications and hand, foot, and mouth disease. The intestinal mucosal immune system has a complete immune response and immune regulation mechanism, consisting of densely arranged ...
Dong Y, Liu J, Lu N, Zhang C.
europepmc   +2 more sources

Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals. [PDF]

BMC Immunol, 2022
Background Plasmacytoid and myeloid dendritic cells play a vital role in the protection against viral infections. In COVID-19, there is an impairment of dendritic cell (DC) function and interferon secretion which has been correlated with disease severity.
Rajamanickam A, Kumar NP, Pandiaraj AN, Selvaraj N, Munisankar S, Renji RM, Venkatramani V, Murhekar M, Thangaraj JWV, Kumar MS, Kumar CPG, Bhatnagar T, Ponnaiah M, Sabarinathan R, Saravanakumar V, Babu S.   +15 more
europepmc   +2 more sources

Increased Sensitivity of SARS-CoV-2 to Type III Interferon in Human Intestinal Epithelial Cells. [PDF]

J Virol, 2022
SARS-CoV-2 infection is not restricted to the respiratory tract and a large number of COVID-19 patients experience gastrointestinal distress. Interferons are key molecules produced by the cell to combat virus infection.
Metz-Zumaran C, Kee C, Doldan P, Guo C, Stanifer ML, Boulant S.   +5 more
europepmc   +2 more sources

Insights Into Type I and III Interferons in Asthma and Exacerbations [PDF]

Frontiers in Immunology, 2020
Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich, Danielle Antos, Natalie R. Melton, John F. Alcorn, Michelle L. Manni   +4 more
doaj   +3 more sources

Context‐specific anti‐inflammatory roles of type III interferon signaling in the lung in nonviral injuries [PDF]

Physiological Reports
Type III interferons (λ1, λ2, and λ3) are potent antiviral cytokines in the lung. However, their roles in nonviral lung injuries are less well understood. This study investigates the activation of type III interferon signaling in three distinct models of
Jingjing Feng, Jooyoung Kim, Victoria D. Wang, De Chang, Hongbo Liu, William G. Bain, Keven M. Robinson, Zhijun Jie, Sergei V. Kotenko, Charles S. Dela Cruz, Lokesh Sharma   +10 more
doaj   +2 more sources

The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon. [PDF]

Nat Microbiol, 2020
Evidence has accumulated to demonstrate that the intestinal microbiota enhances mammalian enteric virus infections1. For example, we and others previously reported that commensal bacteria stimulate acute and persistent murine norovirus infections2–4 ...
Grau KR, Zhu S, Peterson ST, Helm EW, Philip D, Phillips M, Hernandez A, Turula H, Frasse P, Graziano VR, Wilen CB, Wobus CE, Baldridge MT, Karst SM.   +13 more
europepmc   +2 more sources

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.

Cell Rep, 2020
Summary Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is an unprecedented worldwide health problem that requires concerted and global approaches to stop the coronavirus 2019 (COVID-19) pandemic.
Stanifer ML, Kee C, Cortese M, Zumaran CM, Triana S, Mukenhirn M, Kraeusslich HG, Alexandrov T, Bartenschlager R, Boulant S.   +9 more
europepmc   +2 more sources

Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon Induction by Targeting RIG-I Signaling. [PDF]

J Virol, 2020
MERS-CoV causes death of about 35% of patients. Published studies showed that some coronaviruses are capable of suppressing interferon (IFN) expression in the early phase of infection and MERS-CoV proteins can modulate host immune response. In this study,
Chang CY, Liu HM, Chang MF, Chang SC.
europepmc   +2 more sources