Interferon Lambda in the Pathogenesis of Inflammatory Bowel Diseases [PDF]
Frontiers in Immunology, 2021 Interferon λ (IFN-λ) is critical for host viral defense at mucosal surfaces and stimulates immunomodulatory signals, acting on epithelial cells and few other cell types due to restricted IFN-λ receptor expression. Epithelial cells of the intestine play a
David A Constant, Timothy J Nice
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Macrophage Coordination of the Interferon Lambda Immune Response [PDF]
Frontiers in Immunology, 2019 Lambda interferons (IFN-λs) are a major component of the innate immune defense to viruses, bacteria, and fungi. In human liver, IFN-λ not only drives antiviral responses, but also promotes inflammation and fibrosis in viral and non-viral diseases.
Vincent Lam, Scott Read, David Booth
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Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza [PDF]
Frontiers in Immunology, 2021 Interferon lambda (IFNλ) signaling is a promising therapeutic target against viral infection in murine models, yet little is known about its molecular regulation and its cognate receptor, interferon lambda receptor 1 (IFNLR1) in human lung.
James Londino +2 more
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Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling [PDF]
Viruses, 2023 Interferon lambdas (IFNLs) are innate immune cytokines that induce antiviral cellular responses by signaling through a heterodimer composed of IL10RB and the interferon lambda receptor 1 (IFNLR1). Multiple IFNLR1 transcriptional variants are expressed in
Grayson Evans +2 more
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Interferon lambda in respiratory viral infection: immunomodulatory functions and antiviral effects in epithelium [PDF]
Frontiers in ImmunologyType III interferon (IFN-λ), a new member of the IFN family, was initially considered to possess antiviral functions similar to those of type I interferon, both of which are induced via the JAK/STAT pathway.
Yong-Hong Liao +2 more
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Interferon Lambda: The Next Frontier in Antiviral Therapy? [PDF]
PharmaceuticalsType III interferons (IFN-λ) are the most recently identified members of the interferon family, distantly related to type I interferons and members of the interleukin-10 (IL-10).
Sofia Chronopoulou, Ilias Tsochantaridis
doaj +2 more sources
Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir
Microorganisms, 2021 Influenza viruses are a leading cause of morbidity and mortality worldwide. These air-borne pathogens are able to cross the species barrier, leading to regular seasonal epidemics and sporadic pandemics.
Caroline Tapparel Vu +2 more
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Interferon Lambda Signaling Restrains Experimental Autoimmune Encephalomyelitis [PDF]
BiomedicinesIFN-λ is a type III interferon (IFN) with pleiotropic functions in modulating immune responses. To address its function in autoimmune neuroinflammation, we evaluated the development and progression of experimental autoimmune encephalitis (EAE) in IFNLR1 ...
Mohammad Asif Sherwani +4 more
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Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice [PDF]
Virus ResearchRecent studies indicate that treatment of chronic hepatitis D virus (HDV) with either pegylated interferon (IFN)λ or pegylated IFNα monotherapy leads to a dramatic decline in HDV RNA. Herein, we investigated the innate antiviral efficacy of IFNλ and IFNα
Sarah Duehren +12 more
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Frontiers in Immunology, 2021 Interferon lambdas (IFNλ) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver, and gastrointestinal tract. Humans have four IFNλs (1–4), where IFNλ1–3 show ~80%–95% homology,
Steeve Boulant +2 more
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