Results 21 to 30 of about 11,143 (161)

Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology [PDF]

mBio
Type III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investigated. We sought
Drake T. Philip, Nigel M. Goins, Nicholas J. Catanzaro, Ichiro Misumi, Jason K. Whitmire, Hannah M. Atkins, Helen M. Lazear   +6 more
doaj   +2 more sources

Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections [PDF]

Frontiers in Immunology, 2017
Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Sanghyun Lee, Megan T. Baldridge
doaj   +4 more sources

Potential of Interferon Lambda as an Inhibitor of SARS-CoV-2. [PDF]

Mol Biol, 2023
The study provides an overview of scientific results on the feasibility of using type III interferons against SARS-CoV-2. We have analyzed data obtained from the PubMed electronic database for the period 2020‒2022. The results of our own studies of pharmacological substances based on recombinant IFN-λ1 and its pegylated form are also presented ...
Oleinik LA, Madonov PG, Pykhtina MB.
europepmc   +4 more sources

Interferon lambda 4 is a gut antimicrobial protein. [PDF]

Proc Natl Acad Sci U S A
To withstand complex microbial challenges, the mammalian gut largely depends on the secretion of diverse antimicrobial proteins. Type III interferons (IFNλs) are ordinarily considered inducible antiviral cytokines involved in intestinal immunity. Unlike other IFNλs, we found that newly identified IFNλ4 is an intestinal antibacterial protein.
Xiao X, Wang J, Ma J, Peng X, Wu S, Chen X, Lu H, Tan C, Fang L, Xiao S.   +9 more
europepmc   +3 more sources

Interferon lambda in inflammation and autoimmune rheumatic diseases. [PDF]

Nat Rev Rheumatol, 2021
Interferons are potent antiviral cytokines that modulate immunity in response to infection or other danger signals. In addition to their antiviral functions, type I interferons (IFNα and IFNβ) are important in the pathogenesis of autoimmune diseases.
Goel RR, Kotenko SV, Kaplan MJ.
europepmc   +4 more sources

Interferon lambdas: the next cytokine storm [PDF]

Gut, 2011
For two decades the scientific community has sought to understand why some people clear hepatitis C virus (HCV) and others do not. Recently, several large genome-wide association studies have identified single nucleotide polymorphisms (SNPs) linked to interferon lambda 3 (IFNλ3) that are associated with the spontaneous resolution and successful ...
Kelly, C, Klenerman, P, Barnes, E
openaire   +5 more sources

Investigation of the antiviral activity of the recombinant human interferon lambda 1 in human conjunctiva cell culture

Сибирский научный медицинский журнал, 2021
The aim of the study was to determine the efficacy of recombinant human interferon lambda 1 (IFN-λ1) against human adenovirus serotype 5 in a culture of human conjunctival cells Chang conjunctiva clone 1-5c-4. Material and methods.
N. A. Kikhtenko, T. N. Ilyicheva, A. G. Durymanov, A. Zh. Fursova, P. G. Madonov   +4 more
doaj   +1 more source

Different Mechanisms Are Utilized by Coronavirus Transmissible Gastroenteritis Virus To Regulate Interferon Lambda 1 and Interferon Lambda 3 Production. [PDF]

J Virol, 2022
Coronaviruses cause infectious diseases in various mammals and birds and exhibit an epithelial cell tropism in enteric and respiratory tracts. It is critical to explore how coronavirus infections modulate IFN-λ, a key innate cytokine against mucosal viral infection.
Xue M, Wang W, He H, Li L, Zhang X, Shi H, Liu P, Feng L.   +7 more
europepmc   +3 more sources

INTERFERON LAMBDA-3 AS A NEW CANDIDATE GENE INVOLVED IN THE PROGRESSION OF IDIOPATHIC PULMONARY FIBROSIS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2022
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial respiratory illness with an unknown origin, which leads to inevitably fatal outcomes in the majority of cases. The pro-inflammatory cytokine interferon lambda-3 (IFN-λ3) has been
Eman Hamdi, Amany Abdelrehim, Aliaa Higazi, Abo Bakr Ahmed, Khaled Thabet   +4 more
doaj   +1 more source

Antiviral Activity of Lambda Interferon in Chickens [PDF]

Journal of Virology, 2014
ABSTRACTInterferons (IFNs) are essential components of the antiviral defense system of vertebrates. In mammals, functional receptors for type III IFN (lambda interferon [IFN-λ]) are found mainly on epithelial cells, and IFN-λ was demonstrated to play a crucial role in limiting viral infections of mucosal surfaces.
Reuter, Antje, Soubies, S., Härtle, Sonja, Schusser, Benjamin, Kaspers, Bernd, Stäheli, Peter, Rubbenstroth, Dennis, García-Sastre, Adolfo   +7 more
openaire   +3 more sources