Results 21 to 30 of about 12,132 (131)
Frontiers in Immunology, 2021 Interferon lambdas (IFNλ) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver, and gastrointestinal tract. Humans have four IFNλs (1–4), where IFNλ1–3 show ~80%–95% homology,
Cuncai Guo +11 more
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An anti-influenza combined therapy assessed by single cell RNA-sequencing
Communications Biology, 2022 When combined with interferon lambda, virucidal sialylated cyclodextrins inhibit the replication of a clinical H1N1 influenza strain in ex vivo human airway epithelia more efficiently than when delivered alone.
Chiara Medaglia +10 more
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Lambda Interferons: New Cytokines with Old Functions
Pharmaceuticals, 2010 Interferon lambda (IFN-λ) is a member of the class II cytokine family, and like the other members of this family, they are small helical proteins. Since their discovery significant efforts have been made to determine their role in innate and adaptive ...
Ole J. Hamming +3 more
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Treatment with Ad5-Porcine Interferon-α Attenuates Ebolavirus Disease in Pigs
Pathogens, 2022 Under experimental conditions, pigs infected with Ebola Virus (EBOV) develop disease and can readily transmit the virus to non-human primates or pigs. In the event of accidental or intentional EBOV infection of domestic pigs, complex and time-consuming ...
Chandrika Senthilkumaran +10 more
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COVID‐19: lambda interferon against viral load and hyperinflammation
EMBO Molecular Medicine, 2020 Coronavirus disease 2019 (COVID‐19), triggered by the betacoronavirus SARS‐CoV‐2, has become one of the worst pandemics of our time that has already caused more than 250,000 deaths (JHU data‐05/06/2020, https://coronavirus.jhu.edu/ ).
Evangelos Andreakos, Sotirios Tsiodras
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mSphere of Influence: Interferon Ultra Is a Means To Fight Viral Disease
mSphere, 2020 Connor G. G. Bamford works in the fields of virology and innate immunity. In this mSphere of Influence article, he reflects on how three papers by Manry et al. (J. Manry, G. Laval, E. Patin, S.
Connor G. G. Bamford
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PLoS ONE, 2016 BackgroundHepatitis C virus infection is a global health problem. New direct-acting antiviral agents have been recently approved. However, due to their high cost and some genotypes remaining difficult to treat, interferon-based therapy with pegylated ...
Ran Chen +4 more
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Macrophage Coordination of the Interferon Lambda Immune Response
Frontiers in Immunology, 2019 Lambda interferons (IFN-λs) are a major component of the innate immune defense to viruses, bacteria, and fungi. In human liver, IFN-λ not only drives antiviral responses, but also promotes inflammation and fibrosis in viral and non-viral diseases.
Scott A. Read +17 more
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Journal of Inflammation Research, 2021 Scott A Read,1– 3 Brian S Gloss,4 Christopher Liddle,3 Jacob George,3 Golo Ahlenstiel1– 3 1Blacktown Clinical School, Western Sydney University, Blacktown, NSW, 2148, Australia; 2Blacktown Hospital, WSLHD, Blacktown, NSW, 2148, Australia ...
Read SA +4 more
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Interferon lambda 1 is associated with dengue severity in Thailand
International Journal of Infectious Diseases, 2020 Objectives: Patients with dengue exhibit a range of symptoms from an acute febrile illness (dengue fever, DF), to dengue hemorrhagic fever (DHF), and to the most severe outcome, dengue shock syndrome (DSS).
Unchana Arayasongsak +8 more
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