Results 41 to 50 of about 11,209 (176)
Interferon induction by the immunomodulating polyanion lambda carrageenan [PDF]
Infection and Immunity, 1979 The lambda fraction of carrageenan induced murine interferon, which was characterized by sensitivity to trypsin and inhibition by pretreatment of target cells with actinomycin D.
E V, Turner, G, Sonnenfeld
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Journal of Inflammation Research, 2021 Scott A Read,1– 3 Brian S Gloss,4 Christopher Liddle,3 Jacob George,3 Golo Ahlenstiel1– 3 1Blacktown Clinical School, Western Sydney University, Blacktown, NSW, 2148, Australia; 2Blacktown Hospital, WSLHD, Blacktown, NSW, 2148, Australia ...
Read SA +4 more
doaj
Interferon Lambda: Modulating Immunity in Infectious Diseases [PDF]
Frontiers in Immunology, 2017 Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the heterodimeric IFN-λ receptor (IFNLR), activating a STAT phosphorylation-dependent signaling cascade.
Syedbasha M, Egli A
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IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment
EMBO Molecular Medicine, 2016 Influenza A virus (IAV)‐induced severe disease is characterized by infected lung epithelia, robust inflammatory responses and acute lung injury.
Sophia Davidson +7 more
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Interferon lambda 1 is associated with dengue severity in Thailand
International Journal of Infectious Diseases, 2020 Objectives: Patients with dengue exhibit a range of symptoms from an acute febrile illness (dengue fever, DF), to dengue hemorrhagic fever (DHF), and to the most severe outcome, dengue shock syndrome (DSS).
Unchana Arayasongsak +8 more
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PLoS ONE, 2009 BackgroundType-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. However, their homologous relationship is difficult to detect on the basis of sequence alone. We have previously described
Brian A Fox +2 more
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346 The contribution of interferon lambda to sle [PDF]
Poster Session, 2017 Background and aims Interferon lambda (IFN-λ) is a novel type of interferon produced by dendritic cells (DC). Despite its binding to a different receptor, IFN-λ shares functional similarities with type I IFN (IFN-I) by upregulating the expression of IFN-stimulated genes. The role of IFN-λ in DC biology and in autoimmunity remains unknown. to identify
C Macri +4 more
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PLoS ONE, 2014 BackgroundIL28B gene polymorphism is the best baseline predictor of response to interferon alfa-based antiviral therapies in chronic hepatitis C. Recently, a new IFN-L4 polymorphism was identified as first potential functional variant for induction of ...
Simone Susser +8 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
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Frontiers in Immunology, 2019 Type III interferon-lambda (IFN-λ) plays a critical role against infection, particularly in mucosal infection in the respiratory and gastrointestinal tract.
Liang Li +5 more
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