Results 41 to 50 of about 11,143 (161)
Interferon induction by the immunomodulating polyanion lambda carrageenan [PDF]
Infection and Immunity, 1979 The lambda fraction of carrageenan induced murine interferon, which was characterized by sensitivity to trypsin and inhibition by pretreatment of target cells with actinomycin D.
E V, Turner, G, Sonnenfeld
openaire +2 more sources
Interferon-Lambda: A New Addition to an Old Family [PDF]
Journal of Interferon & Cytokine Research, 2010 The discovery and initial description of the interferon-lambda (IFN-lambda) family in early 2003 opened an exciting new chapter in the field of IFN research. There are 3 IFN-lambda genes that encode 3 distinct but highly related proteins denoted IFN-lambda1, -lambda2, and -lambda3. These proteins are also known as interleukin-29 (IL-29), IL-28A, and IL-
Raymond P, Donnelly, Sergei V, Kotenko
openaire +2 more sources
Journal of Inflammation Research, 2021 Scott A Read,1– 3 Brian S Gloss,4 Christopher Liddle,3 Jacob George,3 Golo Ahlenstiel1– 3 1Blacktown Clinical School, Western Sydney University, Blacktown, NSW, 2148, Australia; 2Blacktown Hospital, WSLHD, Blacktown, NSW, 2148, Australia ...
Read SA +4 more
doaj
Interferon Lambda: Modulating Immunity in Infectious Diseases [PDF]
Frontiers in Immunology, 2017 Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the heterodimeric IFN-λ receptor (IFNLR), activating a STAT phosphorylation-dependent signaling cascade.
Syedbasha M, Egli A
openaire +3 more sources
IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment
EMBO Molecular Medicine, 2016 Influenza A virus (IAV)‐induced severe disease is characterized by infected lung epithelia, robust inflammatory responses and acute lung injury.
Sophia Davidson +7 more
doaj +1 more source
PLoS ONE, 2009 BackgroundType-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. However, their homologous relationship is difficult to detect on the basis of sequence alone. We have previously described
Brian A Fox +2 more
doaj +1 more source
Interferons lambda, new cytokines with antiviral activity
Acta virologica, 2013 Interferons (IFNs) are key cytokines in the establishment of a multifaceted antiviral response. Three distinct types of IFNs are now recognized (type I, type II, and type III) based on their receptor usage, structural features and biological activities.
K, Lopušná +6 more
openaire +3 more sources
PLoS ONE, 2014 BackgroundIL28B gene polymorphism is the best baseline predictor of response to interferon alfa-based antiviral therapies in chronic hepatitis C. Recently, a new IFN-L4 polymorphism was identified as first potential functional variant for induction of ...
Simone Susser +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Frontiers in Immunology, 2019 Type III interferon-lambda (IFN-λ) plays a critical role against infection, particularly in mucosal infection in the respiratory and gastrointestinal tract.
Liang Li +5 more
doaj +1 more source