Results 51 to 60 of about 11,143 (161)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

346 The contribution of interferon lambda to sle [PDF]

Poster Session, 2017
Background and aims Interferon lambda (IFN-λ) is a novel type of interferon produced by dendritic cells (DC). Despite its binding to a different receptor, IFN-λ shares functional similarities with type I IFN (IFN-I) by upregulating the expression of IFN-stimulated genes. The role of IFN-λ in DC biology and in autoimmunity remains unknown. to identify
C Macri, ES Pang, J Pooley, K Radford, M O’Keeffe   +4 more
openaire   +1 more source

Macrophages and neutrophils express IFNλs in granulomas from Mycobacterium tuberculosis-infected nonhuman primates

Frontiers in Immunology, 2022
Granulomas are the hallmark of Mycobacterium tuberculosis (Mtb) infection. Cytokine-mediated signaling can modulate immune function; thus, understanding the cytokine milieu in granulomas is critical for understanding immunity in tuberculosis (TB ...
Priyanka Talukdar, Priyanka Talukdar, Beth F. Junecko, Beth F. Junecko, Daniel S. Lane, Daniel S. Lane, Pauline Maiello, Pauline Maiello, Joshua T. Mattila, Joshua T. Mattila   +9 more
doaj   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo [PDF]

Journal of Virology, 2010
ABSTRACT The type I alpha/beta interferons (IFN-α/β) are known to play an important role in host defense against influenza A virus infection, but we have now discovered that the recently identified type III IFNs (IFN-λ) constitute the major response to intranasal infection with this virus.
Nancy A, Jewell, Troy, Cline, Sara E, Mertz, Sergey V, Smirnov, Emilio, Flaño, Christian, Schindler, Jessica L, Grieves, Russell K, Durbin, Sergei V, Kotenko, Joan E, Durbin   +9 more
openaire   +3 more sources

Interferon lambda 4 genotype and pathway in alcoholic hepatitis

Scandinavian Journal of Gastroenterology, 2021
Single nucleotide polymorphisms within the interferon lambda 4 (IFNL4) gene influence liver inflammation and fibrosis in chronic liver disease. We investigated whether this is also the case during acute liver disease, alcoholic hepatitis. We, therefore, related variants within the IFNL4 gene to the clinical course of acute alcoholic hepatitis, and ...
Sidsel Støy (286606), Ewa Terczynska-Dyla (10168167), Sanne Skovgård Veidal (10168170), Kristoffer Rigbolt (10168173), Hendrik Vilstrup (58370), Henning Grønbaek (4740789), Rune Hartmann (344261), Thomas D. Sandahl (8088377)   +7 more
openaire   +4 more sources

Favorable Genotypes of Type III Interferon Confer Risk of Dyslipidemia in the Population With Obesity

Frontiers in Endocrinology, 2022
BackgroundStudies have indicated that the chronic state of inflammation caused by obesity leads to dyslipidemia. However, how the polymorphisms involved in these inflammatory pathways affect the lipid metabolism in people with obesity is poorly ...
Tiantian Xu, Tiantian Xu, Tiantian Xu, Tiantian Xu, Bo Peng, Mengmeng Liu, Mengmeng Liu, Mengmeng Liu, Qingjing Liu, Qingjing Liu, Qingjing Liu, Junya Yang, Minli Qu, Minli Qu, Minli Qu, Na Liu, Na Liu, Na Liu, Lizhen Lin, Lizhen Lin, Lizhen Lin, Jing Wu, Jing Wu, Jing Wu, Jing Wu   +24 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Host and viral mechanisms of congenital Zika syndrome

Virulence, 2019
In 2015–2016, in the Americas, and especially in northeast Brazil, a significant number of cases of microcephaly and other congenital brain abnormalities were linked with an outbreak of Zika virus (ZIKV) infection in pregnant women.
Brooke Liang, José Paulo Guida, Maria Laura Costa, Indira U. Mysorekar   +3 more
doaj   +1 more source