Different Mechanisms Are Utilized by Coronavirus Transmissible Gastroenteritis Virus To Regulate Interferon Lambda 1 and Interferon Lambda 3 Production. [PDF]
J Virol, 2022 Coronaviruses cause infectious diseases in various mammals and birds and exhibit an epithelial cell tropism in enteric and respiratory tracts. It is critical to explore how coronavirus infections modulate IFN-λ, a key innate cytokine against mucosal viral infection.
Xue M +7 more
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Investigations of Interferon-Lambda for the Treatment of Cancer [PDF]
Journal of Innate Immunity, 2015 Interferon-lambda (IFN-λ), a recently discovered cytokine, overlaps broadly with type I IFN signaling, producing antiviral, antiproliferative, and proapoptotic responses. In comparison to type I IFNs, IFN-λ has a limited spectrum of responsive tissues due to variation in expression of the IFN-λ receptor IFNLR1.
Andrew, Stiff, William, Carson
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Virology Journal, 2021 Background The recent pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has elevated several clinical and scientific questions.
Pooneh Rahimi +8 more
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An anti-influenza combined therapy assessed by single cell RNA-sequencing
Communications Biology, 2022 When combined with interferon lambda, virucidal sialylated cyclodextrins inhibit the replication of a clinical H1N1 influenza strain in ex vivo human airway epithelia more efficiently than when delivered alone.
Chiara Medaglia +10 more
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Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. [PDF]
, 2010 Specific differences in signaling and antiviral properties between the different Lambda-interferons, a novel group of interferons composed of IL-28A, IL-28B and IL-29, are currently unknown.
Ralf Bartenschlager +19 more
core +1 more source
, 1998 3 pages: Leadership Lambda, Inc. cover sheet, a 1998-1999 Seminar Series roster of participants, and a list of the 1998-1999 class.
Leadership Lambda, Inc.
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Interferon-Lambda: A New Addition to an Old Family [PDF]
Journal of Interferon & Cytokine Research, 2010 The discovery and initial description of the interferon-lambda (IFN-lambda) family in early 2003 opened an exciting new chapter in the field of IFN research. There are 3 IFN-lambda genes that encode 3 distinct but highly related proteins denoted IFN-lambda1, -lambda2, and -lambda3. These proteins are also known as interleukin-29 (IL-29), IL-28A, and IL-
Raymond P, Donnelly, Sergei V, Kotenko
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Interferon signalling in the liver : implications for the natural course and therapy of hepatitis C [PDF]
, 2012 Hepatitis C virus is a global health concern, estimated to infect 2-3% of the world's population. Inter-individual differences in the course of infection and response to therapy, highlighted by recent genomewide association studies, point to the crucial ...
Makowska, Zuzanna
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Interferon induction by the immunomodulating polyanion lambda carrageenan [PDF]
Infection and Immunity, 1979 The lambda fraction of carrageenan induced murine interferon, which was characterized by sensitivity to trypsin and inhibition by pretreatment of target cells with actinomycin D.
E V, Turner, G, Sonnenfeld
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Treatment with Ad5-Porcine Interferon-α Attenuates Ebolavirus Disease in Pigs
Pathogens, 2022 Under experimental conditions, pigs infected with Ebola Virus (EBOV) develop disease and can readily transmit the virus to non-human primates or pigs. In the event of accidental or intentional EBOV infection of domestic pigs, complex and time-consuming ...
Chandrika Senthilkumaran +10 more
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