Results 31 to 40 of about 11,209 (176)

Investigations of Interferon-Lambda for the Treatment of Cancer [PDF]

Journal of Innate Immunity, 2015
Interferon-lambda (IFN-λ), a recently discovered cytokine, overlaps broadly with type I IFN signaling, producing antiviral, antiproliferative, and proapoptotic responses. In comparison to type I IFNs, IFN-λ has a limited spectrum of responsive tissues due to variation in expression of the IFN-λ receptor IFNLR1.
Andrew, Stiff, William, Carson
openaire   +2 more sources

The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients

Virology Journal, 2021
Background The recent pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has elevated several clinical and scientific questions.
Pooneh Rahimi, Rahil Tarharoudi, Alireza Rahimpour, Jalal Mosayebi Amroabadi, Iraj Ahmadi, Enayat Anvari, Seyed Davar Siadat, Mohammadreza Aghasadeghi, Abolfazl Fateh   +8 more
doaj   +1 more source

Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins

Frontiers in Immunology, 2021
Interferon lambdas (IFNλ) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver, and gastrointestinal tract. Humans have four IFNλs (1–4), where IFNλ1–3 show ~80%–95% homology,
Cuncai Guo, Dorothee Reuss, Jonathon D. Coey, Swathi Sukumar, Benjamin Lang, John McLauchlan, Steeve Boulant, Steeve Boulant, Steeve Boulant, Megan L. Stanifer, Megan L. Stanifer, Connor G. G. Bamford   +11 more
doaj   +1 more source

An anti-influenza combined therapy assessed by single cell RNA-sequencing

Communications Biology, 2022
When combined with interferon lambda, virucidal sialylated cyclodextrins inhibit the replication of a clinical H1N1 influenza strain in ex vivo human airway epithelia more efficiently than when delivered alone.
Chiara Medaglia, Ilya Kolpakov, Arnaud Charles-Antoine Zwygart, Yong Zhu, Samuel Constant, Song Huang, Valeria Cagno, Emmanouil T. Dermitzakis, Francesco Stellacci, Ioannis Xenarios, Caroline Tapparel   +10 more
doaj   +1 more source

Interferon lambda receptor-1 isoforms differentially influence gene expression and HBV replication in stem cell-derived hepatocytes [PDF]

Antiviral Research
Grayson Evans, Eric Meissner, Haitao Guo   +2 more
exaly   +2 more sources

Treatment with Ad5-Porcine Interferon-α Attenuates Ebolavirus Disease in Pigs

Pathogens, 2022
Under experimental conditions, pigs infected with Ebola Virus (EBOV) develop disease and can readily transmit the virus to non-human primates or pigs. In the event of accidental or intentional EBOV infection of domestic pigs, complex and time-consuming ...
Chandrika Senthilkumaran, Andrea L. Kroeker, Gregory Smith, Carissa Embury-Hyatt, Brad Collignon, Elizabeth Ramirez-Medina, Paul A. Azzinaro, Bradley S. Pickering, Fayna Diaz-San Segundo, Hana M. Weingartl, Teresa de los Santos   +10 more
doaj   +1 more source

COVID‐19: lambda interferon against viral load and hyperinflammation

EMBO Molecular Medicine, 2020
Coronavirus disease 2019 (COVID‐19), triggered by the betacoronavirus SARS‐CoV‐2, has become one of the worst pandemics of our time that has already caused more than 250,000 deaths (JHU data‐05/06/2020, https://coronavirus.jhu.edu/ ).
Evangelos Andreakos, Sotirios Tsiodras
doaj   +1 more source

mSphere of Influence: Interferon Ultra Is a Means To Fight Viral Disease

mSphere, 2020
Connor G. G. Bamford works in the fields of virology and innate immunity. In this mSphere of Influence article, he reflects on how three papers by Manry et al. (J. Manry, G. Laval, E. Patin, S.
Connor G. G. Bamford
doaj   +1 more source

Interferon-Lambda: A New Addition to an Old Family [PDF]

Journal of Interferon & Cytokine Research, 2010
The discovery and initial description of the interferon-lambda (IFN-lambda) family in early 2003 opened an exciting new chapter in the field of IFN research. There are 3 IFN-lambda genes that encode 3 distinct but highly related proteins denoted IFN-lambda1, -lambda2, and -lambda3. These proteins are also known as interleukin-29 (IL-29), IL-28A, and IL-
Raymond P, Donnelly, Sergei V, Kotenko
openaire   +2 more sources

Intrinsic Viral Factors Are the Dominant Determinants of the Hepatitis C Virus Response to Interferon Alpha Treatment in Chimeric Mice.

PLoS ONE, 2016
BackgroundHepatitis C virus infection is a global health problem. New direct-acting antiviral agents have been recently approved. However, due to their high cost and some genotypes remaining difficult to treat, interferon-based therapy with pegylated ...
Ran Chen, Michelle Kobewka, William Addison, Gerald Lachance, D Lorne Tyrrell   +4 more
doaj   +1 more source