Interferon Lambda Genetics and Biology in Regulation of Viral Control [PDF]
Frontiers in Immunology, 2017 Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral ...
Ram Savan, Michael Gale, Emily Hemann
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Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections [PDF]
Frontiers in Immunology, 2017 Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Sanghyun Lee, Megan Baldridge
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Interferons lambda – therapeutic application [PDF]
Сибирский научный медицинский журнал, 2020 Interferons are a group of protein molecules with a broad spectrum of effects on the human body. Interferon lambda (type III interferon) was discovered comparatively recently about 20 years ago and its action is still poorly understood.
N. A. Kikhtenko +4 more
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Lambda Interferons: New Cytokines with Old Functions [PDF]
Pharmaceuticals, 2010 Interferon lambda (IFN-λ) is a member of the class II cytokine family, and like the other members of this family, they are small helical proteins. Since their discovery significant efforts have been made to determine their role in innate and adaptive ...
Ole J. Hamming +3 more
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Interferon Lambda: A New Sword in Cancer Immunotherapy [PDF]
Clinical and Developmental Immunology, 2011 The discovery of the interferon-lambda (IFN-λ) family has considerably contributed to our understanding of the role of interferon not only in viral infections but also in cancer. IFN-λ proteins belong to the new type III IFN group.
Ahmed Lasfar +3 more
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Homeostatic pockets of interferon lambda-stimulated gene production in the intestine are associated with localized exposure to bacterial microbiota [PDF]
Gut MicrobesTolerance of enteric microbiota and clearance of potential pathogens is critical for gut homeostasis. We previously found that the healthy small intestine of mice contains discrete pockets of antiviral gene expression that depend on bacterial microbiota ...
David A. Constant +5 more
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Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda [PDF]
Cell ReportsSummary: Cell-intrinsic antiviral gene expression by intestinal epithelial cells (IECs) limits infection by enteric viral pathogens. Here, we find that neonatal IECs express antiviral genes at homeostasis that depend on interferon lambda (IFN-λ) and are ...
Bryan Ramirez Reyes +6 more
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Association of Interferon Lambda 3 and 4 Gene SNPs and Their Expression with COVID-19 Disease Severity: A Cross-Sectional Study [PDF]
Infection and Drug Resistance, 2023 Warisha Zahid,1,* Nida Farooqui,2,* Nida Zahid,3,* Khalid Ahmed,2 Muhammad Faraz Anwar,4 Syed Rizwan-ul-Hasan,5 Azhar R Hussain,2 Antonio Sarría-Santamera,6 Syed Hani Abidi2,6 1Department of Community Health Sciences, Aga Khan University ...
Zahid W +8 more
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Roles and Effects of Interferon Lambda Signaling in the Context of Bacterial Infections [PDF]
Journal of Interferon and Cytokine Research, 2023 Nicholas Carbonetti
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Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology [PDF]
mBioType III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investigated. We sought
Drake T. Philip +6 more
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