Interferons lambda – therapeutic application [PDF]
Сибирский научный медицинский журнал, 2020 Interferons are a group of protein molecules with a broad spectrum of effects on the human body. Interferon lambda (type III interferon) was discovered comparatively recently about 20 years ago and its action is still poorly understood.
N. A. Kikhtenko +4 more
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Expression and function of interferon lambda receptor 1 variants [PDF]
FEBS LettersLambda interferons (IFNLs) provide critical host defense against pathogens encountered at mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell‐type restricted expression of the lambda interferon receptor 1 protein with expression restricted primarily to epithelial cells located at mucosal surfaces.
Eric Meissner
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Lambda Interferons: New Cytokines with Old Functions [PDF]
Pharmaceuticals, 2010 Interferon lambda (IFN-λ) is a member of the class II cytokine family, and like the other members of this family, they are small helical proteins. Since their discovery significant efforts have been made to determine their role in innate and adaptive ...
Ole J. Hamming +3 more
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Macrophage Coordination of the Interferon Lambda Immune Response [PDF]
Frontiers in Immunology, 2019 Lambda interferons (IFN-λs) are a major component of the innate immune defense to viruses, bacteria, and fungi. In human liver, IFN-λ not only drives antiviral responses, but also promotes inflammation and fibrosis in viral and non-viral diseases.
Scott A. Read +17 more
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Interferon Lambda: A New Sword in Cancer Immunotherapy [PDF]
Clinical and Developmental Immunology, 2011 The discovery of the interferon-lambda (IFN-λ) family has considerably contributed to our understanding of the role of interferon not only in viral infections but also in cancer. IFN-λ proteins belong to the new type III IFN group.
Ahmed Lasfar +3 more
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Association of Interferon Lambda 3 and 4 Gene SNPs and Their Expression with COVID-19 Disease Severity: A Cross-Sectional Study [PDF]
Infection and Drug Resistance, 2023 Warisha Zahid,1,* Nida Farooqui,2,* Nida Zahid,3,* Khalid Ahmed,2 Muhammad Faraz Anwar,4 Syed Rizwan-ul-Hasan,5 Azhar R Hussain,2 Antonio Sarría-Santamera,6 Syed Hani Abidi2,6 1Department of Community Health Sciences, Aga Khan University ...
Zahid W +8 more
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Roles and Effects of Interferon Lambda Signaling in the Context of Bacterial Infections [PDF]
Journal of Interferon and Cytokine Research, 2023 Nicholas Carbonetti
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Interferon Lambda Genetics and Biology in Regulation of Viral Control [PDF]
Frontiers in Immunology, 2017 Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral ...
Emily A. Hemann, Michael Gale, Ram Savan
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Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology [PDF]
mBioType III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investigated. We sought
Drake T. Philip +6 more
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Early Treatment with Pegylated Interferon Lambda for Covid-19 [PDF]
New England Journal of Medicine, 2023 Ofir Harari +2 more
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