Results 41 to 50 of about 9,940,893 (244)

Type III Interferons in Antiviral Defenses at Barrier Surfaces [PDF]

Trends in Immunology, 2018
Barrier surfaces such as the epithelium lining the respiratory and gastrointestinal (GI) tracts, the endothelium comprising the blood-brain barrier (BBB), and placental trophoblasts provide key physical and immunological protection against viruses. These barriers utilize nonredundant mechanisms to suppress viral infections including the production of ...
Wells, Alexandra I, Coyne, Carolyn B
openaire   +2 more sources

An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response [PDF]

, 2014
Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, IFN-dependent upregulation of IFN-stimulated genes (ISGs) and the activity of various ...
Fernández, Yolanda, Oliveros, JC, Randall, Richard E, Asensio, Víctor J, Killip, Marian J., Randall, RE, Oliveros, Juan Carlos, Killip, Marian J, Asensio, Víctor J., Bengoechea, Jose Antonio, Oliveros, Juan C., Pérez-Cidoncha, Maite, Pérez-Cidoncha, M, Bengoechea, JA, Bengoechea, José A; id_orcid, Ortín, Juan, Killip, MJ, Ortín, J, Asensio, Víctor José, Randall, Richard E., Bengoechea, José A., Asensio, VJ, Oliveros, Juan C, Fernández, Y   +23 more
core   +1 more source

TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma.

PLoS ONE, 2013
Defective Rhinovirus induced interferon-β and interferon-λ production has been reported in bronchial epithelial cells from asthmatics but the mechanisms of defective interferon induction in asthma are unknown.
Annemarie Sykes, Michael R Edwards, Jonathan Macintyre, Ajerico Del Rosario, Vera Gielen, Jennifer Haas, Onn Min Kon, Mark McHale, Sebastian L Johnston   +8 more
doaj   +1 more source

Life-Threatening Influenza, Hemophagocytic Lymphohistiocytosis and Probable Vaccine-Strain Varicella in a Novel Case of Homozygous STAT2 Deficiency

Frontiers in Immunology, 2021
STAT2 is a transcription factor that plays an essential role in antiviral immunity by mediating the activity of type I and III interferons (IFN-I and IFN-III).
Bishara J. Freij, Bishara J. Freij, Aidan T. Hanrath, Rui Chen, Sophie Hambleton, Sophie Hambleton, Christopher J. A. Duncan, Christopher J. A. Duncan   +7 more
doaj   +1 more source

Interferon signaling in viral hepatitis [PDF]

, 2013
Hepatitis C virus (HCV) is a single stranded positive RNA virus classified in 6 different genotypes. Hepatocytes are the main targets of HCV infection. It has been estimated that 60 to 70% of the infected patients develop chronic infection.
Trincucci, Gaia
core   +1 more source

The role of interferons type I, II and III in myositis: A review [PDF]

Brain Pathology, 2021
AbstractThe classification of idiopathic inflammatory myopathies (IIM) is based on clinical, serological and histological criteria. The identification of myositis‐specific antibodies has helped to define more homogeneous groups of myositis into four dominant subsets: dermatomyositis (DM), antisynthetase syndrome (ASyS), sporadic inclusion body myositis
Bolko, Loïs, Jiang, Wei, Tawara, Nozomu, Landon-Cardinal, Océane, Anquetil, Céline, Benveniste, Olivier, Allenbach, Yves   +6 more
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Astrocyte Control of Zika Infection Is Independent of Interferon Type I and Type III Expression

Biology, 2022
Zika virus (ZIKV) is a pathogenic neurotropic virus that infects the central nervous system (CNS) and results in various neurological complications. Astrocytes are the dominant CNS cell producer of the antiviral cytokine IFN-β, however little is known ...
Mithun Das, Monique L. Smith, Tomomi Furihata, Subir Sarker, Ross O’Shea, Karla J. Helbig   +5 more
doaj   +1 more source

Generation of replication-proficient Influenza Virus NS1 point mutants with interferon-hyperinducer phenotype [PDF]

, 2014
The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN.
Fernández, Yolanda, Juan Ortín, Randall, Richard E, Richard E. Randall (190211), Killip, Marian J, Víctor J Asensio, Bengoechea, José A, Pérez-Cidoncha, M, Marian J. Killip (571160), Marian J Killip, Maite Pérez-Cidoncha (195699), Ortín, Juan, Killip, MJ, Ortín, J, Richard E Randall, Juan Ortín (5649007), Yolanda Fernández, Fernández, Y, Asensio, Víctor J, Randall, RE, José A Bengoechea, José A. Bengoechea (124595), Pérez-Cidoncha, Maite, Bengoechea, JA, Víctor J. Asensio (571161), Bengoechea, José A; id_orcid, Maite Pérez-Cidoncha, Asensio, VJ, Yolanda Fernández (268684), Bengoechea, Jose Antonio, Asensio, Víctor José, Randall, Richard E.   +31 more
core   +2 more sources

Downregulation of type III interferons in patients with severe COVID‐19 [PDF]

Journal of Medical Virology, 2021
AbstractCoronavirus disease 2019 (COVID‐19) is globally rampant, and to curb the growing burden of this disease, in‐depth knowledge about its pathophysiology is needed. This was an observational study conducted at a single center to investigate serum cytokine and chemokine levels of COVID‐19 patients, based on disease severity.
Yosuke Fukuda, Tetsuya Homma, Hideki Inoue, Chisato Onitsuka, Hitoshi Ikeda, Yuiko Goto, Yoko Sato, Tomoyuki Kimura, Kuniaki Hirai, Shin Ohta, Mayumi Yamamoto, Sojiro Kusumoto, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara   +14 more
openaire   +2 more sources

Antiviral Type I and Type III Interferon Responses in the Central Nervous System

Viruses, 2013
The central nervous system (CNS) harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB) from toxic substances and pathogens
Thomas Michiels, Frédéric Sorgeloos, Marguerite Kreit, Cécile Lardinois, Pascale Hermant   +4 more
doaj   +1 more source