Results 41 to 50 of about 277,742 (285)
Peripheral inflammation is associated with remote global gene expression changes in the brain [PDF]
, 2014 Background: Although the central nervous system (CNS) was once considered an immunologically privileged site, in recent years it has become increasingly evident that cross talk between the immune system and the CNS does occur. As a result, patients with
Cavanagh, Jonathan +3 more
core +2 more sources
Type III Interferons in Hepatitis C Virus Infection [PDF]
Frontiers in Immunology, 2016 The interferon (IFN)-λ family of type III cytokines includes the closely related interleukin (IL)-28A (IFN-λ2), IL-28B (IFN-λ3), and IL-29 (IFN-λ1). They signal through the Janus kinases (JAK)-signal transducers and activators of transcription pathway and promote an antiviral state by the induction of expression of several interferon-stimulated genes ...
Boisvert, Maude, Shoukry, Naglaa H.
openaire +2 more sources
Induction of a type I interferon signature in normal human monocytes by gadolinium-based contrast agents: comparison of linear and macrocyclic agents. [PDF]
, 2013 The gadolinium-based contrast agent (GdBCA) Omniscan activates human macrophages through Toll-like receptor (TLR)-4 and TLR-7 signalling. To explore the mechanisms responsible we compared the ability of linear and macrocyclic GdBCA to induce a type I ...
Jimenez, Sergio A., Wermuth, Peter J
core +2 more sources
Virulence, 2020 Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear.
William O. Hahn +2 more
doaj +1 more source
Type III Interferons in Viral Infection and Antiviral Immunity [PDF]
Cellular Physiology and Biochemistry, 2018 Interferons (IFNs) can serve as the first line of immune defense against viral infection. The identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral immune response to viruses contains more components than the type I IFNs that have been known for more than 50 years. IFN-λs are IFN-λ1 (IL-29), IFN-λ2 (IL-28a),
Jian-hua Zhou +5 more
openaire +3 more sources
Type III Interferons in Antiviral Defenses at Barrier Surfaces [PDF]
Trends in Immunology, 2018 Barrier surfaces such as the epithelium lining the respiratory and gastrointestinal (GI) tracts, the endothelium comprising the blood-brain barrier (BBB), and placental trophoblasts provide key physical and immunological protection against viruses. These barriers utilize nonredundant mechanisms to suppress viral infections including the production of ...
Wells, Alexandra I, Coyne, Carolyn B
openaire +2 more sources
Viral Immunology, 2021 While an appropriately regulated production of interferons (IFNs) performs a fundamental role in the defense against coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), dysregulated overproduction of inflammatory mediators can play an important role in the development of SARS-CoV-2 infection-related complications, such ...
Jafarzadeh, Abdollah +4 more
openaire +2 more sources
The role of interferons type I, II and III in myositis: A review [PDF]
Brain Pathology, 2021 AbstractThe classification of idiopathic inflammatory myopathies (IIM) is based on clinical, serological and histological criteria. The identification of myositis‐specific antibodies has helped to define more homogeneous groups of myositis into four dominant subsets: dermatomyositis (DM), antisynthetase syndrome (ASyS), sporadic inclusion body myositis
Bolko, Loïs +6 more
openaire +2 more sources
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
core +1 more source
Frontiers in Immunology, 2021 STAT2 is a transcription factor that plays an essential role in antiviral immunity by mediating the activity of type I and III interferons (IFN-I and IFN-III).
Bishara J. Freij +7 more
doaj +1 more source