Results 41 to 50 of about 606,510 (165)

Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1

Frontiers in Immunology, 2021
Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections.
Tamiris Azamor, Tamiris Azamor, Daniela Prado Cunha, Andréa Marques Vieira da Silva, Ohanna Cavalcanti de Lima Bezerra, Marcelo Ribeiro-Alves, Thyago Leal Calvo, Fernanda de Souza Gomes Kehdy, Fernanda Saloum de Neves Manta, Thiago Gomes de Toledo Pinto, Laís Pereira Ferreira, Elyzabeth Avvad Portari, Letícia da Cunha Guida, Leonardo Gomes, Maria Elisabeth Lopes Moreira, Elizeu Fagundes de Carvalho, Cynthia Chester Cardoso, Marcelo Muller, Ana Paula Dinis Ano Bom, Patrícia Cristina da Costa Neves, Zilton Vasconcelos, Milton Ozório Moraes   +21 more
doaj   +1 more source

Guarding the frontiers: the biology of type III interferons [PDF]

Nature Immunology, 2015
Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier tissues. IFN-λs thereby help to maintain healthy mucosal surfaces through immune protection, without
Andreas Wack, Ewa Terczyńska-Dyla, Rune Hartmann   +2 more
openaire   +4 more sources

Sarbecovirus ORF6 proteins hamper induction of interferon signaling

Cell Reports, 2021
Summary: The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses.
Izumi Kimura, Yoriyuki Konno, Keiya Uriu, Kristina Hopfensperger, Daniel Sauter, So Nakagawa, Kei Sato   +6 more
doaj   +1 more source

Regulation of apoptosis by type III interferons [PDF]

Cell Proliferation, 2008
Abstract.  Objective: Two types of interferons (IFNs), type I (IFN‐α/β) and type III (IFN‐λs), utilize distinct receptor complexes to induce similar signalling and biological activities, including recently demonstrated for IFN‐λs antitumour activity. However, ability of type III IFNs to regulate cell population growth remains largely uncharacterized ...
W, Li, A, Lewis-Antes, J, Huang, M, Balan, S V, Kotenko   +4 more
openaire   +2 more sources

The Role of Type III Interferons in Human Disease

Clinical and Investigative Medicine, 2021
Purpose This literature review summarizes the main immunological characteristics of type III interferons (IFN) and highlights the clinically relevant aspects and future therapeutic perspectives for these inflammatory molecules. Source Relevant articles in PubMed MEDLINE from the first publication (2003) until 2020.
Malik, Anikó Éva, Issekutz, Thomas B, Dérfalvi, Beáta   +2 more
openaire   +4 more sources

Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces

Frontiers in Immunology, 2020
Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs). The
Megan L. Stanifer, Cuncai Guo, Patricio Doldan, Steeve Boulant, Steeve Boulant   +4 more
doaj   +1 more source

Inhibition of SARS–CoV-2 by type I and type III interferons [PDF]

Journal of Biological Chemistry, 2020
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested the inhibitory activities of the antiviral interferons of type I (IFN-α) and type III (IFN-λ) against SARS-CoV-2 and compared them with those against SARS-CoV-1, which emerged in ...
Felgenhauer, Ulrike, Schoen, Andreas, Gad, Hans Henrik, Hartmann, Rune, Schaubmar, Andreas R., Failing, Klaus, Drosten, Christian, Weber, Friedemann   +7 more
openaire   +2 more sources

Human interferon-λ3 is a potent member of the type III interferon family [PDF]

Genes & Immunity, 2008
Type III interferon (IFN) or IFN-lambda is a recently discovered family of IFNs that signal through the same downstream transcription factors as type I IFN but use a separate receptor complex composed of the IL-10R2 and the unique IFN-lambdaR1 receptor chains.
Dellgren, C, Gad, Hans Henrik; id_orcid 0000-0001-8449-1115, Hamming, O J, Melchjorsen, J, Hartmann, R   +4 more
openaire   +3 more sources

Photochemotherapy Induces Interferon Type III Expression via STING Pathway

Cells, 2020
DNA-damaging cancer therapies induce interferon expression and stimulate the immune system, promoting therapy responses. The immune-activating STING (Stimulator of Interferon Genes) pathway is induced when DNA or double-stranded RNA (dsRNA) is detected ...
Edyta Biskup, Brian Daniel Larsen, Leonor Rib, Lasse Folkersen, Omid Niazi, Maria R. Kamstrup, Claus Storgaard Sørensen   +6 more
doaj   +1 more source

Shared and Distinct Functions of Type I and Type III Interferons [PDF]

Immunity, 2019
Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. However, recent discoveries have revealed context-specific functional differences.
Helen M, Lazear, John W, Schoggins, Michael S, Diamond   +2 more
openaire   +2 more sources