Results 51 to 60 of about 10,540,033 (277)

Interferon-producing cells are enriched for defective influenza segments.

, 2021
(A) Differential gene expression analysis on interferon-enriched and -depleted populations. An A549 type I interferon reporter cell line was infected at an MOI of 0.1 and sorted using magnetic-activated cell sorting 14 hours post infection.
Marisa Mendes (11820361), Alistair B. Russell (11820364)   +1 more
core   +1 more source

TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma.

PLoS ONE, 2013
Defective Rhinovirus induced interferon-β and interferon-λ production has been reported in bronchial epithelial cells from asthmatics but the mechanisms of defective interferon induction in asthma are unknown.
Annemarie Sykes, Michael R Edwards, Jonathan Macintyre, Ajerico Del Rosario, Vera Gielen, Jennifer Haas, Onn Min Kon, Mark McHale, Sebastian L Johnston   +8 more
doaj   +1 more source

Life-Threatening Influenza, Hemophagocytic Lymphohistiocytosis and Probable Vaccine-Strain Varicella in a Novel Case of Homozygous STAT2 Deficiency

Frontiers in Immunology, 2021
STAT2 is a transcription factor that plays an essential role in antiviral immunity by mediating the activity of type I and III interferons (IFN-I and IFN-III).
Bishara J. Freij, Bishara J. Freij, Aidan T. Hanrath, Rui Chen, Sophie Hambleton, Sophie Hambleton, Christopher J. A. Duncan, Christopher J. A. Duncan   +7 more
doaj   +1 more source

The role of interferons type I, II and III in myositis: A review [PDF]

Brain Pathology, 2021
AbstractThe classification of idiopathic inflammatory myopathies (IIM) is based on clinical, serological and histological criteria. The identification of myositis‐specific antibodies has helped to define more homogeneous groups of myositis into four dominant subsets: dermatomyositis (DM), antisynthetase syndrome (ASyS), sporadic inclusion body myositis
Bolko, Loïs, Jiang, Wei, Tawara, Nozomu, Landon-Cardinal, Océane, Anquetil, Céline, Benveniste, Olivier, Allenbach, Yves   +6 more
openaire   +2 more sources

Astrocyte Control of Zika Infection Is Independent of Interferon Type I and Type III Expression

Biology, 2022
Zika virus (ZIKV) is a pathogenic neurotropic virus that infects the central nervous system (CNS) and results in various neurological complications. Astrocytes are the dominant CNS cell producer of the antiviral cytokine IFN-β, however little is known ...
Mithun Das, Monique L. Smith, Tomomi Furihata, Subir Sarker, Ross O’Shea, Karla J. Helbig   +5 more
doaj   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source

Downregulation of type III interferons in patients with severe COVID‐19 [PDF]

Journal of Medical Virology, 2021
AbstractCoronavirus disease 2019 (COVID‐19) is globally rampant, and to curb the growing burden of this disease, in‐depth knowledge about its pathophysiology is needed. This was an observational study conducted at a single center to investigate serum cytokine and chemokine levels of COVID‐19 patients, based on disease severity.
Yosuke Fukuda, Tetsuya Homma, Hideki Inoue, Chisato Onitsuka, Hitoshi Ikeda, Yuiko Goto, Yoko Sato, Tomoyuki Kimura, Kuniaki Hirai, Shin Ohta, Mayumi Yamamoto, Sojiro Kusumoto, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara   +14 more
openaire   +2 more sources

Bunyaviruses and the type I interferon system [PDF]

, 2009
The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott, Weber, F., Richard Elliott, Elliott, Richard Michael, Friedemann Weber, Weber, F, Elliott, R.M.   +6 more
core   +1 more source

Antiviral Type I and Type III Interferon Responses in the Central Nervous System

Viruses, 2013
The central nervous system (CNS) harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB) from toxic substances and pathogens
Thomas Michiels, Frédéric Sorgeloos, Marguerite Kreit, Cécile Lardinois, Pascale Hermant   +4 more
doaj   +1 more source

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

, 2014
Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons.
Franz, Kate M., Evelyn Dixit, Lee Gehrke, Franz, Kate M, Boulant, Steeve, Fabrizia Stavru, Steeve Boulant, Stavru, Fabrizia, Bierne, Hélène, Fiegen Durbin, Ann, Durbin, Ann F, Odendall, Charlotte, Pascale Cossart, Fiegen, Ann, Charlotte Odendall, Gehrke, Lee, Durbin, Ann Fiegen, Kate M. Franz, Ann Fiegen Durbin, Jonathan C Kagan, Kagan, Jonathan C, Ann Fiegen, Cossart, Pascale, Dixit, Evelyn, Helene Bierne, Kagan, Jonathan, Jonathan C. Kagan, Kate M Franz   +27 more
core   +1 more source