Results 51 to 60 of about 606,510 (165)
The Role of Structure in the Biology of Interferon Signaling
Frontiers in Immunology, 2020 Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic programs that enhance resistance to viral infection. Induction of an antiviral state at the cell, tissue, organ, and organismal level is performed by three ...
Mark R. Walter
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Roles of Type I and III Interferons in COVID-19
Yonsei Medical Journal, 2021 Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells.
Hojun Choi, Eui-Cheol Shin
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The Capsule of Acinetobacter baumannii Protects against the Innate Immune Response
Journal of Innate Immunity, 2022 Acinetobacter baumannii is an opportunistic pathogen that has recently emerged as a global threat associated with high morbidity, mortality, and antibiotic resistance. We determined the role of type I interferon (IFN) signaling in A. baumannii infection.
Lavoisier Akoolo +3 more
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Microbial pathogenesis and type III interferons
Cytokine & Growth Factor Reviews, 2016 The innate immune system possesses a multitude of pathways to sense and respond to microbial pathogens. One such family are the interferons (IFNs), a family of cytokines that are involved in several cellular functions. Type I IFNs are appreciated to be important in several viral and bacterial diseases, while the recently identified type III IFNs (IFNL1,
Cohen, Taylor S., Parker, Dane
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Viruses, 2022 Paramyxoviridae is a viral family within the order of Mononegavirales; they are negative single-strand RNA viruses that can cause significant diseases in both humans and animals.
Giuseppe Pisanelli +3 more
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Virulence, 2020 Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear.
William O. Hahn +2 more
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Type III Interferons in Hepatitis C Virus Infection [PDF]
Frontiers in Immunology, 2016 The interferon (IFN)-λ family of type III cytokines includes the closely related interleukin (IL)-28A (IFN-λ2), IL-28B (IFN-λ3), and IL-29 (IFN-λ1). They signal through the Janus kinases (JAK)-signal transducers and activators of transcription pathway and promote an antiviral state by the induction of expression of several interferon-stimulated genes ...
Boisvert, Maude, Shoukry, Naglaa H.
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The role of interferons type I, II and III in myositis: A review [PDF]
Brain Pathology, 2021 AbstractThe classification of idiopathic inflammatory myopathies (IIM) is based on clinical, serological and histological criteria. The identification of myositis‐specific antibodies has helped to define more homogeneous groups of myositis into four dominant subsets: dermatomyositis (DM), antisynthetase syndrome (ASyS), sporadic inclusion body myositis
Bolko, Loïs +6 more
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Type III Interferons in Viral Infection and Antiviral Immunity [PDF]
Cellular Physiology and Biochemistry, 2018 Interferons (IFNs) can serve as the first line of immune defense against viral infection. The identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral immune response to viruses contains more components than the type I IFNs that have been known for more than 50 years. IFN-λs are IFN-λ1 (IL-29), IFN-λ2 (IL-28a),
Jian-hua Zhou +5 more
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Viral Immunology, 2021 While an appropriately regulated production of interferons (IFNs) performs a fundamental role in the defense against coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), dysregulated overproduction of inflammatory mediators can play an important role in the development of SARS-CoV-2 infection-related complications, such ...
Jafarzadeh, Abdollah +4 more
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