Results 51 to 60 of about 9,940,893 (244)

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response [PDF]

, 2009
The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates
Fragkoudis, R., Kohl, A., Rodriguez-Andres, J., Kohl, Alain, Breakwell, L, Barry, G, Fazakerley, J.K., Breakwell, Lucy, Attarzadeh-Yazdi, G., Kohl, A, Barry, Gerald, Fazakerley, John K, Attarzadeh-Yazdi, G, Fazakerley, JK, Fragkoudis, R, Barry, G., Attarzadeh-Yazdi, Ghassem, Rodriguez-Andres, J, Breakwell, L., Rodriguez-Andres, Julio, Fragkoudis, Rennos   +20 more
core   +1 more source

Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line

BMC Molecular and Cell Biology, 2020
Background Interferon-alpha (IFNα) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic side-effects limited its clinical application. Interferon-lambda (IFNλ) with comparable antiviral activity and less
Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng, Ping Chen   +6 more
doaj   +1 more source

Novel Nonviral Bioassays for Mouse Type I and Type III Interferon [PDF]

Journal of Interferon & Cytokine Research, 2011
We used embryo fibroblasts from Mx2-Luc transgenic mice that express Firefly luciferase under control of the interferon (IFN)-regulated mouse Mx2 promoter to develop simple nonviral bioassays for type I and type III IFN. Since type III IFN is acid-labile, Mx2-Luc fibroblasts detected the presence of type I IFN in acid-treated biological samples with ...
Kugel, Daniela, Pulverer, Julia Elisabeth, Köster, Mario, Hauser, Hansjörg, Stäheli, Peter   +4 more
openaire   +4 more sources

Differential host responses by the type I and III interferons in primary differentiated human nasal epithelial cells are a determinant of antiviral activity

Frontiers in Pharmacology
BackgroundThe interferon (IFN) response is a crucial innate antiviral defence mechanism at the airway epithelium. The epithelial IFN response is predominantly mediated by the type I (IFN-β1) and III (IFN-λ) IFNs, which activate a transcriptional program ...
Douglas Jie Wen Tay, Douglas Jie Wen Tay, Hui Yi Tay, Hui Yi Tay, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Kai Sen Tan, Kai Sen Tan   +8 more
doaj   +1 more source

Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection

mBio, 2016
Much of the morbidity and mortality associated with influenza virus respiratory infection is due to bacterial coinfection with pathogens that colonize the upper respiratory tract such as methicillin-resistant Staphylococcus aureus (MRSA) and ...
Paul J. Planet, Dane Parker, Taylor S. Cohen, Hannah Smith, Justinne D. Leon, Chanelle Ryan, Tobin J. Hammer, Noah Fierer, Emily I. Chen, Alice S. Prince   +9 more
doaj   +1 more source

Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a. [PDF]

, 2004
S100B belongs to a family of calcium-binding proteins implicated in intracellular and extracellular regulatory activities. This study of serum S100B in primary progressive multiple sclerosis (PPMS) is based on data obtained from a randomized, controlled ...
Lim, Ee Tuan, Leary, Siobhan M, Geoff Keir, Petzold, Axel, Thompson, Alan J, Gavin Giovannoni, Siobhan M Leary, Altmann, Daniel R, Keir, Geoff, Ee Tuan Lim, David H Miller, Ed J Thompson, Giovannoni, Gavin, Miller, David H, Alan J Thompson, Daniel R Altmann, Thompson, Ed J, Axel Petzold   +17 more
core   +2 more sources

Interferon Lambda Genetics and Biology in Regulation of Viral Control

Frontiers in Immunology, 2017
Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral ...
Emily A. Hemann, Michael Gale, Ram Savan
doaj   +1 more source

Studies on interferon (IFN) induction and isolation of IFN-inducing mutant viruses [PDF]

, 2011
The interferon (IFN) system is a powerful antiviral defense system. Host cell pattern recognition receptors (PRRs) recognise pathogen-associated molecule patterns (PAMPs) which when activated, lead to the transcription of the IFN-β gene. As a consequence
Chen, Shu
core   +2 more sources

Functions of IFNλs in Anti-Bacterial Immunity at Mucosal Barriers

Frontiers in Immunology, 2022
Type III interferons (IFNs), or IFNλs, are cytokines produced in response to microbial ligands. They signal through the IFNλ receptor complex (IFNLR), which is located on epithelial cells and select immune cells at barrier sites. As well as being induced
Noémie Alphonse, Noémie Alphonse, Ruth E. Dickenson, Abrar Alrehaili, Charlotte Odendall   +4 more
doaj   +1 more source

Interfering with interferon: developing a reporter system to study the interaction between hepatitus C viral proteins and the interferon signalling pathway [PDF]

, 2008
PhDThe aim of the project was to investigate the mechanism by which HCV evades therapeutic IFN treatment. This involved the development of novel testing systems and their application to patient samples.
Jones, Meleri
core   +4 more sources