Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production. [PDF]
PLoS ONE, 2016 Stress granules (SGs) are cytoplasmic granular aggregations that are induced by cellular stress, including viral infection. SGs have opposing antiviral and proviral roles, which depend on virus species. The exact function of SGs during viral infection is
Shin Hashimoto +11 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Ancestral RNA polymerase III (Pol III) is a multi-subunit polymerase responsible for transcription of short non-coding RNA, such as double-stranded short interspersed nuclear elements (SINEs).
Brianna M. Doratt +8 more
doaj +1 more source
Posttreatment Downregulation of Type III Interferons in Patients with Acute Brucellosis
Mediators of Inflammation, 2021 There is a limited number of clinical studies on interferon (IFN) levels in human brucellosis. The novel group of interferons, type III interferons, which consists of four IFN‐ λ (lambda) molecules called IFN‐ λ 1 or interleukin‐29 (IL‐29), IFN‐
Mehran Shokri +6 more
openaire +3 more sources
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Type I and Type III Interferons Differ in Their Adjuvant Activities for Influenza Vaccines [PDF]
Journal of Virology, 2019 Interferons can shape antiviral immune responses, but it is not well understood how they influence vaccine efficacy. We find that type I IFN preferentially promotes the production of antigen-specific IgG2c and IgA antibodies after infection with a live attenuated influenza virus or after immunization with influenza subunit vaccines.
Ye, Liang +6 more
openaire +4 more sources
Generation of replication-proficient Influenza Virus NS1 point mutants with interferon-hyperinducer phenotype [PDF]
, 2014 The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN.
Fernández, Yolanda +39 more
core +2 more sources
Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs
Frontiers in Immunology, 2017 Type III interferons (IFNs) (or IFN-λ) are the latest addition to the IFN family. Even though they share little protein homology with type I IFN, both exhibit remarkable functional similarities: each can be induced in response to viral infections, and ...
Ivan Zanoni +3 more
doaj +1 more source
Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size
iScience, 2022 Summary: The mucosal antiviral role of type I and III interferon in influenza virus infection is well established. However, much less is known about the antiviral mechanism of type II interferon (interferon-gamma).
Carol Ho-Yan Fong +7 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response [PDF]
, 2014 Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, IFN-dependent upregulation of IFN-stimulated genes (ISGs) and the activity of various ...
Fernández, Yolanda +24 more
core +1 more source