Results 71 to 80 of about 606,510 (165)
Interferon Lambda Genetics and Biology in Regulation of Viral Control
Frontiers in Immunology, 2017 Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral ...
Emily A. Hemann, Michael Gale, Ram Savan
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Regulation of type I and type III interferon induction in response to pathogen sensing.
Current Opinion in ImmunologyType I and III interferons (IFN-I and IFN-III) have a central role in the early antimicrobial response against invading pathogens. Induction of IFN-Is and IFN-IIIs arises due to the sensing by pattern recognition receptors of pathogen-associated ...
Hossam Gewaid, A. Bowie
semanticscholar +1 more source
Functions of IFNλs in Anti-Bacterial Immunity at Mucosal Barriers
Frontiers in Immunology, 2022 Type III interferons (IFNs), or IFNλs, are cytokines produced in response to microbial ligands. They signal through the IFNλ receptor complex (IFNLR), which is located on epithelial cells and select immune cells at barrier sites. As well as being induced
Noémie Alphonse +4 more
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Journal of Pharmaceutical AnalysisScutellariae Radix (SR) is widely used in Chinese medicine for influenza treatment; however, the mechanisms underlying its effect remain unknown. Here, we report, for the first time, that the therapeutic effects of SR on influenza involve regulation of ...
Li Li +11 more
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Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production. [PDF]
PLoS ONE, 2016 Stress granules (SGs) are cytoplasmic granular aggregations that are induced by cellular stress, including viral infection. SGs have opposing antiviral and proviral roles, which depend on virus species. The exact function of SGs during viral infection is
Shin Hashimoto +11 more
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Frontiers in Cellular and Infection Microbiology, 2022 Ancestral RNA polymerase III (Pol III) is a multi-subunit polymerase responsible for transcription of short non-coding RNA, such as double-stranded short interspersed nuclear elements (SINEs).
Brianna M. Doratt +8 more
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Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs
Frontiers in Immunology, 2017 Type III interferons (IFNs) (or IFN-λ) are the latest addition to the IFN family. Even though they share little protein homology with type I IFN, both exhibit remarkable functional similarities: each can be induced in response to viral infections, and ...
Ivan Zanoni +3 more
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Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size
iScience, 2022 Summary: The mucosal antiviral role of type I and III interferon in influenza virus infection is well established. However, much less is known about the antiviral mechanism of type II interferon (interferon-gamma).
Carol Ho-Yan Fong +7 more
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Type I and Type III Interferons Differ in Their Adjuvant Activities for Influenza Vaccines [PDF]
Journal of Virology, 2019 Interferons can shape antiviral immune responses, but it is not well understood how they influence vaccine efficacy. We find that type I IFN preferentially promotes the production of antigen-specific IgG2c and IgA antibodies after infection with a live attenuated influenza virus or after immunization with influenza subunit vaccines.
Ye, Liang +6 more
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Posttreatment Downregulation of Type III Interferons in Patients with Acute Brucellosis
Mediators of Inflammation, 2021 There is a limited number of clinical studies on interferon (IFN) levels in human brucellosis. The novel group of interferons, type III interferons, which consists of four IFN‐ λ (lambda) molecules called IFN‐ λ 1 or interleukin‐29 (IL‐29), IFN‐
Mehran Shokri +6 more
openaire +3 more sources