Results 81 to 90 of about 606,510 (165)

Interferon Lambda: A New Sword in Cancer Immunotherapy

Clinical and Developmental Immunology, 2011
The discovery of the interferon-lambda (IFN-λ) family has considerably contributed to our understanding of the role of interferon not only in viral infections but also in cancer. IFN-λ proteins belong to the new type III IFN group.
Ahmed Lasfar, Walid Abushahba, Murugabaskar Balan, Karine A. Cohen-Solal   +3 more
doaj   +1 more source

Regulation and Function of Interferon-Lambda (IFNλ) and Its Receptor in Asthma

Frontiers in Immunology, 2021
Asthma is a chronic respiratory disease affecting people of all ages, especially children, worldwide. Origins of asthma are suggested to be placed in early life with heterogeneous clinical presentation, severity and pathophysiology.
Susanne Krammer, Cristina Sicorschi Gutu, Janina C. Grund, Mircea T. Chiriac, Sabine Zirlik, Susetta Finotto   +5 more
doaj   +1 more source

Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3 Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response

Journal of Virology, 2019
Type III interferons are potent antiviral cytokines important for regulation of viruses that infect at mucosal surfaces. Studies using mice lacking the Ifnlr1 gene encoding the type III interferon receptor have demonstrated that signaling through this ...
Stefan T. Peterson, E. Kennedy, Pamela H. Brigleb, G. Taylor, Kelly Urbanek, T. Bricker, Sanghyun Lee, Haina Shin, T. Dermody, A. Boon, Megan T. Baldridge   +10 more
semanticscholar   +1 more source

Critical role of type III interferon in controlling SARS-CoV-2 infection, replication and spread in primary human intestinal epithelial cells

bioRxiv, 2020
SARS-CoV-2 is an unprecedented worldwide health problem that requires concerted and global approaches to better understand the virus in order to develop novel therapeutic approaches to stop the COVID-19 pandemic and to better prepare against potential ...
M. Stanifer, Carmon Kee, M. Cortese, Sergio Triana, Markus Mukenhirn, H. Kraeusslich, T. Alexandrov, R. Bartenschlager, S. Boulant   +8 more
semanticscholar   +1 more source

Subtype-specific functions of basal IFNλs

Journal of Virology
Type III interferons (IFNλs) represent the newest interferon family, comprising four human subtypes (IFNλ1–4) that signal through the tissue-restricted IFNLR1 receptor. While traditionally characterized as antiviral cytokines protecting mucosal barriers,
Megan L. Stanifer
doaj   +1 more source

TLR7/8 regulates type I and type III interferon signalling in rhinovirus 1b-induced allergic asthma

European Respiratory Journal, 2020
Introduction Interferon (IFN) responses have been reported to be defective in rhinovirus (RV)-induced asthma. The heterodimeric receptor of type I IFN (IFN-α/β) is composed of IFN-αR1 and IFN-αR2.
Jasmin Krug, A. Kiefer, J. Koelle, T. Vuorinen, P. Xepapadaki, B. Stanić, M. Chiriac, M. Akdiş, T. Zimmermann, N. Papadopoulos, S. Finotto   +10 more
semanticscholar   +1 more source

Biological Effects of Chicken Type III Interferon on Expression of Interferon-Stimulated Genes in Chickens: Comparison with Type I and Type II Interferons

Journal of Veterinary Medical Science, 2012
Interferons (IFNs) are key mediators that activate host defense mechanisms against viruses. The recently identified mammalian Type III IFN has biological effects similar to type I IFN. However, the biological effects of type III IFN have not yet been characterized in birds. We compared the effects of chicken type III IFN (IFN-λ) with type I (IFN-β) and
MASUDA, Yasumitsu, MATSUDA, Akiko, USUI, Tatsufumi, SUGAI, Toru, ASANO, Atsushi, YAMANO, Yoshiaki   +5 more
openaire   +3 more sources

The U-Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell-Dependent Manner

mBio, 2020
Hepatitis E virus (HEV) is an important human pathogen causing both acute and chronic viral hepatitis E infection. Currently, the mechanisms of HEV replication and pathogenesis remain poorly understood.
Harini Sooryanarain, C. L. Heffron, Xiang‐Jin Meng   +2 more
semanticscholar   +1 more source

SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism. [PDF]

PLoS Pathogens, 2010
Severe acute respiratory syndrome coronavirus (SARS-CoV) infection often caused severe end stage lung disease and organizing phase diffuse alveolar damage, especially in the elderly.
Matthew B Frieman, Jun Chen, Thomas E Morrison, Alan Whitmore, William Funkhouser, Jerrold M Ward, Elaine W Lamirande, Anjeanette Roberts, Mark Heise, Kanta Subbarao, Ralph S Baric   +10 more
doaj   +1 more source

Hepatitis E virus persists in the presence of a type III interferon response

PLoS Pathogens, 2017
The RIG-I-like RNA helicase (RLR)-mediated interferon (IFN) response plays a pivotal role in the hepatic antiviral immunity. The hepatitis A virus (HAV) and the hepatitis C virus (HCV) counter this response by encoding a viral protease that cleaves the ...
Xin Yin, Xinlei Li, Charuta Ambardekar, Zhimin Hu, S. Lhomme, Zongdi Feng   +5 more
semanticscholar   +1 more source