Results 61 to 70 of about 606,510 (165)

Coronavirus Endoribonuclease Activity in Porcine Epidemic Diarrhea Virus Suppresses Type I and Type III Interferon Responses

Journal of Virology, 2019
Coronaviruses (CoVs) can emerge from an animal reservoir into a naive host species to cause pandemic respiratory or gastrointestinal diseases with significant mortality in humans or domestic animals.
Xufang Deng, Albert G M van Geelen, A. Buckley, A. O’Brien, A. Pillatzki, K. Lager, K. Faaberg, S. Baker   +7 more
semanticscholar   +1 more source

Type III Interferons in Antiviral Defenses at Barrier Surfaces [PDF]

Trends in Immunology, 2018
Barrier surfaces such as the epithelium lining the respiratory and gastrointestinal (GI) tracts, the endothelium comprising the blood-brain barrier (BBB), and placental trophoblasts provide key physical and immunological protection against viruses. These barriers utilize nonredundant mechanisms to suppress viral infections including the production of ...
Wells, Alexandra I, Coyne, Carolyn B
openaire   +2 more sources

TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma.

PLoS ONE, 2013
Defective Rhinovirus induced interferon-β and interferon-λ production has been reported in bronchial epithelial cells from asthmatics but the mechanisms of defective interferon induction in asthma are unknown.
Annemarie Sykes, Michael R Edwards, Jonathan Macintyre, Ajerico Del Rosario, Vera Gielen, Jennifer Haas, Onn Min Kon, Mark McHale, Sebastian L Johnston   +8 more
doaj   +1 more source

Life-Threatening Influenza, Hemophagocytic Lymphohistiocytosis and Probable Vaccine-Strain Varicella in a Novel Case of Homozygous STAT2 Deficiency

Frontiers in Immunology, 2021
STAT2 is a transcription factor that plays an essential role in antiviral immunity by mediating the activity of type I and III interferons (IFN-I and IFN-III).
Bishara J. Freij, Bishara J. Freij, Aidan T. Hanrath, Rui Chen, Sophie Hambleton, Sophie Hambleton, Christopher J. A. Duncan, Christopher J. A. Duncan   +7 more
doaj   +1 more source

Astrocyte Control of Zika Infection Is Independent of Interferon Type I and Type III Expression

Biology, 2022
Zika virus (ZIKV) is a pathogenic neurotropic virus that infects the central nervous system (CNS) and results in various neurological complications. Astrocytes are the dominant CNS cell producer of the antiviral cytokine IFN-β, however little is known ...
Mithun Das, Monique L. Smith, Tomomi Furihata, Subir Sarker, Ross O’Shea, Karla J. Helbig   +5 more
doaj   +1 more source

Oncolytic parainfluenza virus combines with NK cells to mediate killing of infected and non-infected lung cancer cells within 3D spheroids: role of type I and type III interferon signaling

Journal for ImmunoTherapy of Cancer, 2021
Background There is intense interest in developing novel oncolytic viruses, which can be used in cancer therapies along with immune cells such as natural killer (NK) cells.
N. Varudkar, Jeremiah L Oyer, Alicja J Copik, G. Parks   +3 more
semanticscholar   +1 more source

Antiviral Type I and Type III Interferon Responses in the Central Nervous System

Viruses, 2013
The central nervous system (CNS) harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB) from toxic substances and pathogens
Thomas Michiels, Frédéric Sorgeloos, Marguerite Kreit, Cécile Lardinois, Pascale Hermant   +4 more
doaj   +1 more source

Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line

BMC Molecular and Cell Biology, 2020
Background Interferon-alpha (IFNα) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic side-effects limited its clinical application. Interferon-lambda (IFNλ) with comparable antiviral activity and less
Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng, Ping Chen   +6 more
doaj   +1 more source

Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection

mBio, 2016
Much of the morbidity and mortality associated with influenza virus respiratory infection is due to bacterial coinfection with pathogens that colonize the upper respiratory tract such as methicillin-resistant Staphylococcus aureus (MRSA) and ...
Paul J. Planet, Dane Parker, Taylor S. Cohen, Hannah Smith, Justinne D. Leon, Chanelle Ryan, Tobin J. Hammer, Noah Fierer, Emily I. Chen, Alice S. Prince   +9 more
doaj   +1 more source

Novel Nonviral Bioassays for Mouse Type I and Type III Interferon [PDF]

Journal of Interferon & Cytokine Research, 2011
We used embryo fibroblasts from Mx2-Luc transgenic mice that express Firefly luciferase under control of the interferon (IFN)-regulated mouse Mx2 promoter to develop simple nonviral bioassays for type I and type III IFN. Since type III IFN is acid-labile, Mx2-Luc fibroblasts detected the presence of type I IFN in acid-treated biological samples with ...
Kugel, Daniela, Pulverer, Julia Elisabeth, Köster, Mario, Hauser, Hansjörg, Stäheli, Peter   +4 more
openaire   +4 more sources