Results 61 to 70 of about 9,940,893 (244)

Dual regulation of antiviral IFN response by Scutellariae Radix: Therapeutic implications for influenza

Journal of Pharmaceutical Analysis
Scutellariae Radix (SR) is widely used in Chinese medicine for influenza treatment; however, the mechanisms underlying its effect remain unknown. Here, we report, for the first time, that the therapeutic effects of SR on influenza involve regulation of ...
Li Li, Manjing Jiang, Hong Wei, Linpan Liang, Yunlong Song, Dongni Xia, Qiang Luo, Huimin Huang, Xu Li, Haisheng Yang, Lijun Ning, Ying Wu   +11 more
doaj   +1 more source

Inhibition of Type III Interferon Expression in Intestinal Epithelial Cells—A Strategy Used by Coxsackie B Virus to Evade the Host’s Innate Immune Response at the Primary Site of Infection?

Microorganisms, 2021
Increasing evidence highlights the importance of the antiviral activities of the type III interferons (IFNλs; IL-28A, IL-28B, IL29, and IFNλ4) in the intestine.
Virginia M. Stone, Emma E. Ringqvist, Pär G. Larsson, Erna Domsgen, Ulrika Holmlund, Eva Sverremark-Ekström, Malin Flodström-Tullberg   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Transcriptional responses of tumor cell lines to interferon-alpha [PDF]

, 2013
Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production. [PDF]

PLoS ONE, 2016
Stress granules (SGs) are cytoplasmic granular aggregations that are induced by cellular stress, including viral infection. SGs have opposing antiviral and proviral roles, which depend on virus species. The exact function of SGs during viral infection is
Shin Hashimoto, Soh Yamamoto, Noriko Ogasawara, Toyotaka Sato, Keisuke Yamamoto, Hiroshi Katoh, Toru Kubota, Tsukasa Shiraishi, Takashi Kojima, Tetsuo Himi, Hiroyuki Tsutsumi, Shin-Ichi Yokota   +11 more
doaj   +1 more source

Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines

Frontiers in Cellular and Infection Microbiology, 2022
Ancestral RNA polymerase III (Pol III) is a multi-subunit polymerase responsible for transcription of short non-coding RNA, such as double-stranded short interspersed nuclear elements (SINEs).
Brianna M. Doratt, Elizabeth Vance, Elizabeth Vance, Elizabeth Vance, Delphine C. Malherbe, Mark T.W. Ebbert, Mark T.W. Ebbert, Mark T.W. Ebbert, Ilhem Messaoudi   +8 more
doaj   +1 more source

Posttreatment Downregulation of Type III Interferons in Patients with Acute Brucellosis

Mediators of Inflammation, 2021
There is a limited number of clinical studies on interferon (IFN) levels in human brucellosis. The novel group of interferons, type III interferons, which consists of four IFN‐ λ (lambda) molecules called IFN‐ λ 1 or interleukin‐29 (IL‐29), IFN‐
Mehran Shokri, Oreinab Ghaffari Khonakdar, Mousa Mohammadnia-Afrouzi, Mahmoud Sadeghi-Haddad-Zavareh, Amirhossein Hasanpour, Mohammad Barary, Soheil Ebrahimpour   +6 more
openaire   +3 more sources

Interferon, virus vaccines and antiviral drugs [PDF]

, 2008
The emergence of viruses with zoonotic potential, i.e. with the potential ability to cross species barriers to infect unnatural hosts, poses a huge threat to humans.
Rodrigues, Ana Mara Lopes
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source