Results 61 to 70 of about 10,540,033 (277)

Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection [PDF]

, 2013
Background & Aims: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most powerful predictors for sustained virologic response (SVR) in patients with chronic hepatitis C virus (HCV) infection, compared to other biochemical or ...
Simone Susser (48294), Annika Brodzinski, Thomas Berg (186372), Migaud, Pascal, Jacob George (205614), Brodzinski, Annika, Tobias Müller, Susser, Simone, Stephan Böhm (334611), Sarrazin, Christoph, Christoph Sarrazin (48298), Pascal Migaud, Schott, Eckart, Bömmel, Florian van, Heiko Witt, Florian van Bömmel, Janett Fischer, Christoph Sarrazin, Stewart, Graeme, Graeme Stewart, Witt, Heiko, Thomas Berg, Simone Susser, Balazs Fülöp, Fülöp, Balazs, Stephan Böhm, Annika Brodzinski (477753), Balazs Fülöp (477754), Müller, Tobias, Fischer, Janett, Böhm, Stephan, Berg, Thomas, Tobias Müller (163591), Janett Fischer (477751), Eckart Schott (320945), Graeme Stewart (208243), Jacob George, Heiko Witt (161481), Pascal Migaud (477752), George, Jacob, Eckart Schott, Florian van Bömmel (477755), Witt Heiko, Fischer, J;Bohm, S;Müller, T;Witt, H;Sarrazin, C;Susser, S;Migaud, P;Schott, E;Stewart, G;Brodzinski, A;Fülöp, B;Van Bömmel, F;George, J;Berg, T, Böhm Stephan, Susser Simone, Müller Tobias, Fülöp Balazs, Stewart Graeme, Fischer Janett, George Jacob, Brodzinski Annika, Migaud Pascal, Berg Thomas, Sarrazin Christoph, Schott Eckart, van Bömmel Florian   +56 more
core   +1 more source

Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line

BMC Molecular and Cell Biology, 2020
Background Interferon-alpha (IFNα) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic side-effects limited its clinical application. Interferon-lambda (IFNλ) with comparable antiviral activity and less
Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng, Ping Chen   +6 more
doaj   +1 more source

Differential host responses by the type I and III interferons in primary differentiated human nasal epithelial cells are a determinant of antiviral activity

Frontiers in Pharmacology
BackgroundThe interferon (IFN) response is a crucial innate antiviral defence mechanism at the airway epithelium. The epithelial IFN response is predominantly mediated by the type I (IFN-β1) and III (IFN-λ) IFNs, which activate a transcriptional program ...
Douglas Jie Wen Tay, Douglas Jie Wen Tay, Hui Yi Tay, Hui Yi Tay, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Kai Sen Tan, Kai Sen Tan   +8 more
doaj   +1 more source

Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection

mBio, 2016
Much of the morbidity and mortality associated with influenza virus respiratory infection is due to bacterial coinfection with pathogens that colonize the upper respiratory tract such as methicillin-resistant Staphylococcus aureus (MRSA) and ...
Paul J. Planet, Dane Parker, Taylor S. Cohen, Hannah Smith, Justinne D. Leon, Chanelle Ryan, Tobin J. Hammer, Noah Fierer, Emily I. Chen, Alice S. Prince   +9 more
doaj   +1 more source

The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant [PDF]

, 2013
5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials.
Cevayir Coban, Kenji Mizuguchi, Junichi Ito, Etsushi Kuroda, Coban, C, Ishii, KJ, Choon Kit Tang, Shizuo Akira, Jounai, N, Benoit H Dessailly, Ito, J, Keiichi Ohata, Tang, CK, Akira, S, Mizuguchi, K, Ken J Ishii, Kouji Kobiyama, Ohata, K, Nao Jounai, Kuroda, E, Kobiyama, K, Dessailly, BH, Aoshi, T, Taiki Aoshi, Mizuguchi Kenji, Tang Choon Kit, Aoshi Taiki, Jounai Nao, Ishii Ken J., Ito Junichi, Akira Shizuo, Dessailly Benoit H., Kuroda Etsushi, Ohata Keiichi, Kobiyama Kouji, Coban Cevayir   +35 more
core   +1 more source

Interferon Lambda Genetics and Biology in Regulation of Viral Control

Frontiers in Immunology, 2017
Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral ...
Emily A. Hemann, Michael Gale, Ram Savan
doaj   +1 more source

Functions of IFNλs in Anti-Bacterial Immunity at Mucosal Barriers

Frontiers in Immunology, 2022
Type III interferons (IFNs), or IFNλs, are cytokines produced in response to microbial ligands. They signal through the IFNλ receptor complex (IFNLR), which is located on epithelial cells and select immune cells at barrier sites. As well as being induced
Noémie Alphonse, Noémie Alphonse, Ruth E. Dickenson, Abrar Alrehaili, Charlotte Odendall   +4 more
doaj   +1 more source

Dual regulation of antiviral IFN response by Scutellariae Radix: Therapeutic implications for influenza

Journal of Pharmaceutical Analysis
Scutellariae Radix (SR) is widely used in Chinese medicine for influenza treatment; however, the mechanisms underlying its effect remain unknown. Here, we report, for the first time, that the therapeutic effects of SR on influenza involve regulation of ...
Li Li, Manjing Jiang, Hong Wei, Linpan Liang, Yunlong Song, Dongni Xia, Qiang Luo, Huimin Huang, Xu Li, Haisheng Yang, Lijun Ning, Ying Wu   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source