Results 61 to 70 of about 277,742 (285)

Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus [PDF]

, 2017
Lambda interferon (IFN-λ) has potent antiviral effects against multiple enteric viral pathogens, including norovirus and rotavirus, in both preventing and curing infection. Because the intestine includes a diverse array of cell types, however, the cell(s)
Baldridge, Megan T, Brown, Judy J, Dermody, Terence S, Lee, Sanghyun, McAllister, Nicole, Nice, Timothy J, Urbanek, Kelly, Virgin, Herbert W   +7 more
core   +2 more sources

Dual regulation of antiviral IFN response by Scutellariae Radix: Therapeutic implications for influenza

Journal of Pharmaceutical Analysis
Scutellariae Radix (SR) is widely used in Chinese medicine for influenza treatment; however, the mechanisms underlying its effect remain unknown. Here, we report, for the first time, that the therapeutic effects of SR on influenza involve regulation of ...
Li Li, Manjing Jiang, Hong Wei, Linpan Liang, Yunlong Song, Dongni Xia, Qiang Luo, Huimin Huang, Xu Li, Haisheng Yang, Lijun Ning, Ying Wu   +11 more
doaj   +1 more source

Porcine innate and adaptative immune responses to influenza and coronavirus infections [PDF]

, 2006
Both innate and adaptative immune responses contribute to the control of infectious diseases, including by limiting the spreading of zoonotic diseases from animal reservoirs to humans.
Asselin-Paturel, Baudoux, BERNARD CHARLEY, Brim, Charley, Charley, Charley, Chen, Chinsangaram, Corthier, Fitzgerald-Bocarsly, Guzylack-Piriou, Heinen, KRISTIEN VAN REETH, La Bonnardière, Laude, Laude, Le Bon, Lim, Liu, Palese, Peiris, Pestka, Riffault, Riffault, Riffault, Rothenfusser, SABINE RIFFAULT, Saif, Siegal, Summerfield, Tu, Tudor, Van Reeth, Van Reeth, van Reeth   +35 more
core   +2 more sources

Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production. [PDF]

PLoS ONE, 2016
Stress granules (SGs) are cytoplasmic granular aggregations that are induced by cellular stress, including viral infection. SGs have opposing antiviral and proviral roles, which depend on virus species. The exact function of SGs during viral infection is
Shin Hashimoto, Soh Yamamoto, Noriko Ogasawara, Toyotaka Sato, Keisuke Yamamoto, Hiroshi Katoh, Toru Kubota, Tsukasa Shiraishi, Takashi Kojima, Tetsuo Himi, Hiroyuki Tsutsumi, Shin-Ichi Yokota   +11 more
doaj   +1 more source

Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines

Frontiers in Cellular and Infection Microbiology, 2022
Ancestral RNA polymerase III (Pol III) is a multi-subunit polymerase responsible for transcription of short non-coding RNA, such as double-stranded short interspersed nuclear elements (SINEs).
Brianna M. Doratt, Elizabeth Vance, Elizabeth Vance, Elizabeth Vance, Delphine C. Malherbe, Mark T.W. Ebbert, Mark T.W. Ebbert, Mark T.W. Ebbert, Ilhem Messaoudi   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs

Frontiers in Immunology, 2017
Type III interferons (IFNs) (or IFN-λ) are the latest addition to the IFN family. Even though they share little protein homology with type I IFN, both exhibit remarkable functional similarities: each can be induced in response to viral infections, and ...
Ivan Zanoni, Ivan Zanoni, Francesca Granucci, Achille Broggi   +3 more
doaj   +1 more source

Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size

iScience, 2022
Summary: The mucosal antiviral role of type I and III interferon in influenza virus infection is well established. However, much less is known about the antiviral mechanism of type II interferon (interferon-gamma).
Carol Ho-Yan Fong, Lu Lu, Lin-Lei Chen, Man-Lung Yeung, Anna Jinxia Zhang, Hanjun Zhao, Kwok-Yung Yuen, Kelvin Kai-Wang To   +7 more
doaj   +1 more source

Type I and Type III Interferons Differ in Their Adjuvant Activities for Influenza Vaccines [PDF]

Journal of Virology, 2019
Interferons can shape antiviral immune responses, but it is not well understood how they influence vaccine efficacy. We find that type I IFN preferentially promotes the production of antigen-specific IgG2c and IgA antibodies after infection with a live attenuated influenza virus or after immunization with influenza subunit vaccines.
Ye, Liang, Ohnemus, Annette, Ong, Li Ching, Gad, Hans Henrik, Hartmann, Rune, Lycke, Nils, Staeheli, Peter   +6 more
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source