Results 31 to 40 of about 10,540,033 (277)

Type III Interferons: Emerging Roles in Autoimmunity [PDF]

Frontiers in Immunology, 2021
Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs signal via their heterodimeric receptor, comprised of two subunits, IFNLR1 and interleukin (IL)10Rβ, which defines the cellular specificity of the responses to the ...
Sindhu Manivasagam, Sindhu Manivasagam, Robyn S. Klein, Robyn S. Klein, Robyn S. Klein, Robyn S. Klein   +5 more
openaire   +4 more sources

Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1

Frontiers in Immunology, 2021
Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections.
Tamiris Azamor, Tamiris Azamor, Daniela Prado Cunha, Andréa Marques Vieira da Silva, Ohanna Cavalcanti de Lima Bezerra, Marcelo Ribeiro-Alves, Thyago Leal Calvo, Fernanda de Souza Gomes Kehdy, Fernanda Saloum de Neves Manta, Thiago Gomes de Toledo Pinto, Laís Pereira Ferreira, Elyzabeth Avvad Portari, Letícia da Cunha Guida, Leonardo Gomes, Maria Elisabeth Lopes Moreira, Elizeu Fagundes de Carvalho, Cynthia Chester Cardoso, Marcelo Muller, Ana Paula Dinis Ano Bom, Patrícia Cristina da Costa Neves, Zilton Vasconcelos, Milton Ozório Moraes   +21 more
doaj   +1 more source

Regulation of apoptosis by type III interferons [PDF]

Cell Proliferation, 2008
Abstract.  Objective: Two types of interferons (IFNs), type I (IFN‐α/β) and type III (IFN‐λs), utilize distinct receptor complexes to induce similar signalling and biological activities, including recently demonstrated for IFN‐λs antitumour activity. However, ability of type III IFNs to regulate cell population growth remains largely uncharacterized ...
W, Li, A, Lewis-Antes, J, Huang, M, Balan, S V, Kotenko   +4 more
openaire   +2 more sources

The Role of Type III Interferons in Human Disease

Clinical and Investigative Medicine, 2021
Purpose This literature review summarizes the main immunological characteristics of type III interferons (IFN) and highlights the clinically relevant aspects and future therapeutic perspectives for these inflammatory molecules. Source Relevant articles in PubMed MEDLINE from the first publication (2003) until 2020.
Malik, Anikó Éva, Issekutz, Thomas B, Dérfalvi, Beáta   +2 more
openaire   +4 more sources

Sarbecovirus ORF6 proteins hamper induction of interferon signaling

Cell Reports, 2021
Summary: The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses.
Izumi Kimura, Yoriyuki Konno, Keiya Uriu, Kristina Hopfensperger, Daniel Sauter, So Nakagawa, Kei Sato   +6 more
doaj   +1 more source

Inhibition of SARS–CoV-2 by type I and type III interferons [PDF]

Journal of Biological Chemistry, 2020
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested the inhibitory activities of the antiviral interferons of type I (IFN-α) and type III (IFN-λ) against SARS-CoV-2 and compared them with those against SARS-CoV-1, which emerged in ...
Felgenhauer, Ulrike, Schoen, Andreas, Gad, Hans Henrik, Hartmann, Rune, Schaubmar, Andreas R., Failing, Klaus, Drosten, Christian, Weber, Friedemann   +7 more
openaire   +2 more sources

Human interferon-λ3 is a potent member of the type III interferon family [PDF]

Genes & Immunity, 2008
Type III interferon (IFN) or IFN-lambda is a recently discovered family of IFNs that signal through the same downstream transcription factors as type I IFN but use a separate receptor complex composed of the IL-10R2 and the unique IFN-lambdaR1 receptor chains.
Dellgren, C, Gad, Hans Henrik; id_orcid 0000-0001-8449-1115, Hamming, O J, Melchjorsen, J, Hartmann, R   +4 more
openaire   +3 more sources

Shared and Distinct Functions of Type I and Type III Interferons [PDF]

Immunity, 2019
Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. However, recent discoveries have revealed context-specific functional differences.
Helen M, Lazear, John W, Schoggins, Michael S, Diamond   +2 more
openaire   +2 more sources

Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction [PDF]

, 2012
This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD ...
Childs, Kay, Randall, Richard, Goodbourn, Stephen, Randall, Richard; id_orcid   +3 more
core   +2 more sources

The Role of Structure in the Biology of Interferon Signaling

Frontiers in Immunology, 2020
Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic programs that enhance resistance to viral infection. Induction of an antiviral state at the cell, tissue, organ, and organismal level is performed by three ...
Mark R. Walter
doaj   +1 more source