Cell Reports, 2020 Alternative splicing is well understood to enhance proteome diversity as cells respond to stimuli. However, mechanistic understanding for how the spliceosome processes precursor messenger RNA (mRNA) transcripts to achieve template diversification is ...
Tao Xie +2 more
exaly +2 more sources
Antiviral Functions of Type I and Type III Interferons in the Olfactory Epithelium
Biomolecules, 2023 The olfactory neuroepithelium (OE) is one of the few neuronal tissues where environmental pathogens can gain direct access. Despite this vulnerable arrangement, little is known about the protective mechanisms in the OE to prevent viral infection and its ...
Ahmad Zedan +6 more
doaj +5 more sources
Differential type I and type III interferon expression profiles in rheumatoid and juvenile idiopathic arthritis [PDF]
Frontiers in MedicineBackgroundThe role of type I and type III interferons (IFNs) in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) is still poorly understood.
Anikó E. Malik +12 more
doaj +2 more sources
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. [PDF]
PLoS Pathogens, 2018 It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces.
Kalliopi Pervolaraki +10 more
doaj +4 more sources
Diverse intracellular pathogens activate type III interferon expression from peroxisomes
Nature Immunology, 2014 Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons.
Steeve Boulant +2 more
exaly +2 more sources
The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Interferons (IFNs) are secreted proteins of the cytokine family that regulate innate and adaptive immune responses to infection. Although the importance of IFNs in the antiviral response has long been appreciated, their role in bacterial infections is ...
Olivier eDussurget +2 more
doaj +5 more sources
mBio, 2017 Yellow fever virus (YFV) is an arthropod-borne flavivirus, infecting ~200,000 people worldwide annually and causing about 30,000 deaths. The live attenuated vaccine strain, YFV-17D, has significantly contributed in controlling the global burden of yellow
Florian Douam +6 more
doaj +2 more sources
Pseudorabies Virus Inhibits Type I and Type III Interferon-Induced Signaling via Proteasomal Degradation of Janus Kinases. [PDF]
J Virol, 2021 Yin Y, Romero N, Favoreel HW.
europepmc +2 more sources
Type I and type III interferon in opposition? [PDF]
Nat Rev Immunol, 2020 Park MD.
europepmc +4 more sources
Type III Interferons: Emerging Roles in Autoimmunity [PDF]
Frontiers in Immunology, 2021 Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs signal via their heterodimeric receptor, comprised of two subunits, IFNLR1 and interleukin (IL)10Rβ, which defines the cellular specificity of the responses to the ...
Sindhu Manivasagam +5 more
openaire +4 more sources