Results 31 to 40 of about 9,940,893 (244)
Bunyaviruses and the type I interferon system [PDF]
, 2009 The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott +7 more
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Roles of Type I and III Interferons in COVID-19
Yonsei Medical Journal, 2021 Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells.
Hojun Choi, Eui-Cheol Shin
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Interferon signalling in the liver : implications for the natural course and therapy of hepatitis C [PDF]
, 2012 Hepatitis C virus is a global health concern, estimated to infect 2-3% of the world's population. Inter-individual differences in the course of infection and response to therapy, highlighted by recent genomewide association studies, point to the crucial ...
Makowska, Zuzanna
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Viruses, 2022 Paramyxoviridae is a viral family within the order of Mononegavirales; they are negative single-strand RNA viruses that can cause significant diseases in both humans and animals.
Giuseppe Pisanelli +3 more
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Type III Interferons in Hepatitis C Virus Infection [PDF]
Frontiers in Immunology, 2016 The interferon (IFN)-λ family of type III cytokines includes the closely related interleukin (IL)-28A (IFN-λ2), IL-28B (IFN-λ3), and IL-29 (IFN-λ1). They signal through the Janus kinases (JAK)-signal transducers and activators of transcription pathway and promote an antiviral state by the induction of expression of several interferon-stimulated genes ...
Boisvert, Maude, Shoukry, Naglaa H.
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Virulence, 2020 Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear.
William O. Hahn +2 more
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Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection [PDF]
, 2013 Background & Aims: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most powerful predictors for sustained virologic response (SVR) in patients with chronic hepatitis C virus (HCV) infection, compared to other biochemical or ...
Simone Susser (48294) +41 more
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Type III Interferons in Viral Infection and Antiviral Immunity [PDF]
Cellular Physiology and Biochemistry, 2018 Interferons (IFNs) can serve as the first line of immune defense against viral infection. The identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral immune response to viruses contains more components than the type I IFNs that have been known for more than 50 years. IFN-λs are IFN-λ1 (IL-29), IFN-λ2 (IL-28a),
Jian-hua Zhou +5 more
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Viral Immunology, 2021 While an appropriately regulated production of interferons (IFNs) performs a fundamental role in the defense against coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), dysregulated overproduction of inflammatory mediators can play an important role in the development of SARS-CoV-2 infection-related complications, such ...
Jafarzadeh, Abdollah +4 more
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Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]
, 2009 Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul +8 more
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