Herpesviruses and the Type III Interferon System. [PDF]
Virol Sin, 2021 Type III interferons (IFNs) represent the most recently discovered group of IFNs. Together with type I IFNs (e.g. IFN-α/β), type III IFNs (IFN-λ) are produced as part of the innate immune response to virus infection, and elicit an anti-viral state by inducing expression of interferon stimulated genes (ISGs).
Yin Y, Favoreel HW.
europepmc +5 more sources
Editorial: Type I and Type III Interferon Immune Responses in Asthma [PDF]
Frontiers in Immunology, 2022 Editorial on the Research Topic Type I and Type III Interferon Immune Responses in ...
Susetta Finotto +4 more
doaj +8 more sources
Type III interferon is a critical regulator of innate antifungal immunity. [PDF]
Sci Immunol, 2017 Type III interferons activate neutrophils to promote antifungal immune responses to Aspergillus fumigatus. Type III interferons prime neutrophils Type I interferons (IFNs) have a well-established role in antiviral immunity.
Espinosa V +11 more
europepmc +5 more sources
An Engineered Probiotic Produces a Type III Interferon IFNL1 and Reduces Inflammations in in vitro Inflammatory Bowel Disease Models. [PDF]
ACS Biomater Sci Eng, 2023 The etiology of inflammatory bowel diseases (IBDs) frequently results in the uncontrolled inflammation of intestinal epithelial linings and the local environment.
Chua KJ +6 more
europepmc +2 more sources
Synthetic Heterodimers of Type III Interferon Receptors Require TYK2 for STAT Activation. [PDF]
J Interferon Cytokine Res, 2023 Type III interferons (IFN-λ) are central to host defense against viral infection of epithelial barrier surfaces. IFN-λ binding to its receptor induces a JAK-STAT cascade through kinases Janus-associated kinase 1 (JAK1) and tyrosine kinase 2 (TYK2), which
Mesev EV +3 more
europepmc +2 more sources
Reducing off-target drug accumulation by exploiting a type-III interferon response. [PDF]
J Control Release, 2023 Nanomedicines have been touted as the future of cancer therapy for decades. However, the field of tumor-targeted nanomedicine has failed to significantly advance toward becoming the primary choice for cancer intervention.
Tilden SG +3 more
europepmc +2 more sources
A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. [PDF]
PLoS Pathog, 2022 Cryptosporidium is a leading cause of severe diarrhea and diarrheal-related death in children worldwide. As an obligate intracellular parasite, Cryptosporidium relies on intestinal epithelial cells to provide a niche for its growth and survival, but ...
Gibson AR +10 more
europepmc +2 more sources
Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Bronchial epithelia are the primary target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Here, we reconstituted bronchial epithelia from adult and child donors and show that SARS-CoV-2 infections spread fast ...
Beucher G +19 more
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USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING. [PDF]
Cell Death Dis, 2022 Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19 pandemic.
Karlowitz R +12 more
europepmc +2 more sources
Pseudorabies virus-induced expression and antiviral activity of type I or type III interferon depend on the type of infected epithelial cell [PDF]
Frontiers in Immunology, 2022 Type I and III Interferons (IFNs) are the initial antiviral cytokines produced in response to virus infection. These IFNs in turn bind to their respective receptors, trigger JAK-STAT signaling and induce the expression of IFN-stimulated genes (ISGs) to ...
Yue Yin +4 more
doaj +2 more sources