Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction [PDF]
Viruses, 2021 Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis +7 more
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Type III interferon exerts thymic stromal lymphopoietin in mediating adaptive antiviral immune response [PDF]
Frontiers in Immunology, 2023 Previously, it was believed that type III interferon (IFN-III) has functions similar to those of type I interferon (IFN-I). However, recently, emerging findings have increasingly indicated the non-redundant role of IFN-III in innate antiviral immune ...
Luhong Cao +4 more
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Context‐specific anti‐inflammatory roles of type III interferon signaling in the lung in nonviral injuries [PDF]
Physiological ReportsType III interferons (λ1, λ2, and λ3) are potent antiviral cytokines in the lung. However, their roles in nonviral lung injuries are less well understood. This study investigates the activation of type III interferon signaling in three distinct models of
Jingjing Feng +10 more
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Editorial: Type I and Type III Interferon Immune Responses in Asthma [PDF]
Frontiers in Immunology, 2022 Editorial on the Research Topic Type I and Type III Interferon Immune Responses in ...
Susetta Finotto +4 more
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Differential Regulation of Type I and Type III Interferon Signaling [PDF]
International Journal of Molecular Sciences, 2019 Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III.
Kalliopi Pervolaraki +2 more
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Pseudorabies virus-induced expression and antiviral activity of type I or type III interferon depend on the type of infected epithelial cell [PDF]
Frontiers in Immunology, 2022 Type I and III Interferons (IFNs) are the initial antiviral cytokines produced in response to virus infection. These IFNs in turn bind to their respective receptors, trigger JAK-STAT signaling and induce the expression of IFN-stimulated genes (ISGs) to ...
Yue Yin +4 more
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Insights Into Type I and III Interferons in Asthma and Exacerbations [PDF]
Frontiers in Immunology, 2020 Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich +4 more
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Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
Frontiers in Immunology, 2020 Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs). The
Megan L. Stanifer +4 more
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Type III interferon drives pathogenicity to Staphylococcus aureus via the airway epithelium [PDF]
mBioType III interferon signaling contributes to the pathogenesis of the important human pathogen Staphylococcus aureus in the airway. Little is known of the cellular factors important in this response.
Silvia Pires +2 more
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Photochemotherapy Induces Interferon Type III Expression via STING Pathway
Cells, 2020 DNA-damaging cancer therapies induce interferon expression and stimulate the immune system, promoting therapy responses. The immune-activating STING (Stimulator of Interferon Genes) pathway is induced when DNA or double-stranded RNA (dsRNA) is detected ...
Edyta Biskup +6 more
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