TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma. [PDF]
PLoS ONE, 2013 Defective Rhinovirus induced interferon-β and interferon-λ production has been reported in bronchial epithelial cells from asthmatics but the mechanisms of defective interferon induction in asthma are unknown.
Annemarie Sykes +8 more
doaj +9 more sources
Differential Regulation of Type I and Type III Interferon Signaling [PDF]
International Journal of Molecular Sciences, 2019 Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III.
Megan L Stanifer +2 more
exaly +5 more sources
Insights Into Type I and III Interferons in Asthma and Exacerbations [PDF]
Frontiers in Immunology, 2020 Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich +4 more
doaj +3 more sources
Antiviral Functions of Type I and Type III Interferons in the Olfactory Epithelium
Biomolecules, 2023 The olfactory neuroepithelium (OE) is one of the few neuronal tissues where environmental pathogens can gain direct access. Despite this vulnerable arrangement, little is known about the protective mechanisms in the OE to prevent viral infection and its ...
Ahmad Zedan +6 more
doaj +5 more sources
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. [PDF]
PLoS Pathogens, 2018 It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces.
Kalliopi Pervolaraki +10 more
doaj +4 more sources
Antiviral Type I and Type III Interferon Responses in the Central Nervous System [PDF]
Viruses, 2013 The central nervous system (CNS) harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB) from toxic substances and pathogens
Thomas Michiels +4 more
doaj +4 more sources
The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Interferons (IFNs) are secreted proteins of the cytokine family that regulate innate and adaptive immune responses to infection. Although the importance of IFNs in the antiviral response has long been appreciated, their role in bacterial infections is ...
Olivier eDussurget +2 more
doaj +5 more sources
Herpesviruses and the Type III Interferon System. [PDF]
Virol Sin, 2021 Type III interferons (IFNs) represent the most recently discovered group of IFNs. Together with type I IFNs (e.g. IFN-α/β), type III IFNs (IFN-λ) are produced as part of the innate immune response to virus infection, and elicit an anti-viral state by inducing expression of interferon stimulated genes (ISGs).
Yin Y, Favoreel HW.
europepmc +4 more sources
Type I and type III interferon in opposition? [PDF]
Nat Rev Immunol, 2020 Park MD.
europepmc +4 more sources
Type III Interferons: Emerging Roles in Autoimmunity [PDF]
Frontiers in Immunology, 2021 Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs signal via their heterodimeric receptor, comprised of two subunits, IFNLR1 and interleukin (IL)10Rβ, which defines the cellular specificity of the responses to the ...
Sindhu Manivasagam +5 more
openaire +4 more sources