Results 11 to 20 of about 9,940,893 (244)
Editorial: Type I and Type III Interferon Immune Responses in Asthma [PDF]
Frontiers in Immunology, 2022 Editorial on the Research Topic Type I and Type III Interferon Immune Responses in ...
Susetta Finotto +4 more
doaj +8 more sources
Antiviral Functions of Type I and Type III Interferons in the Olfactory Epithelium
Biomolecules, 2023 The olfactory neuroepithelium (OE) is one of the few neuronal tissues where environmental pathogens can gain direct access. Despite this vulnerable arrangement, little is known about the protective mechanisms in the OE to prevent viral infection and its ...
Ahmad Zedan +6 more
doaj +5 more sources
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. [PDF]
PLoS Pathogens, 2018 It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces.
Kalliopi Pervolaraki +10 more
doaj +4 more sources
The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Interferons (IFNs) are secreted proteins of the cytokine family that regulate innate and adaptive immune responses to infection. Although the importance of IFNs in the antiviral response has long been appreciated, their role in bacterial infections is ...
Olivier eDussurget +2 more
doaj +5 more sources
Molecular characterization and antiviral analyses of porcine type III interferons [PDF]
Journal of Interferon & Cytokine Research, 2010 Type III interferons (IFNs) are a family of recently identified antiviral cytokines. One to 3 paralogs have been identified in several species; however, little information is available about type III IFNs in pigs.
Rowland, Raymond R. R. +5 more
core +4 more sources
Type III Interferons: Emerging Roles in Autoimmunity [PDF]
Frontiers in Immunology, 2021 Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs signal via their heterodimeric receptor, comprised of two subunits, IFNLR1 and interleukin (IL)10Rβ, which defines the cellular specificity of the responses to the ...
Sindhu Manivasagam +5 more
openaire +4 more sources
Herpesviruses and the Type III Interferon System
Virologica Sinica, 2021 Type III interferons (IFNs) represent the most recently discovered group of IFNs. Together with type I IFNs (e.g. IFN-α/β), type III IFNs (IFN-λ) are produced as part of the innate immune response to virus infection, and elicit an anti-viral state by inducing expression of interferon stimulated genes (ISGs).
Yue Yin, Herman W. Favoreel
openaire +3 more sources
Guarding the frontiers: the biology of type III interferons [PDF]
Nature Immunology, 2015 Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier tissues. IFN-λs thereby help to maintain healthy mucosal surfaces through immune protection, without
Andreas Wack +2 more
openaire +4 more sources
Regulation of apoptosis by type III interferons [PDF]
Cell Proliferation, 2008 Abstract. Objective: Two types of interferons (IFNs), type I (IFN‐α/β) and type III (IFN‐λs), utilize distinct receptor complexes to induce similar signalling and biological activities, including recently demonstrated for IFN‐λs antitumour activity. However, ability of type III IFNs to regulate cell population growth remains largely uncharacterized ...
W, Li +4 more
openaire +2 more sources
The Role of Type III Interferons in Human Disease
Clinical and Investigative Medicine, 2021 Purpose This literature review summarizes the main immunological characteristics of type III interferons (IFN) and highlights the clinically relevant aspects and future therapeutic perspectives for these inflammatory molecules. Source Relevant articles in PubMed MEDLINE from the first publication (2003) until 2020.
Malik, Anikó Éva +2 more
openaire +4 more sources