Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes [PDF]
, 2019 Type 1 diabetes (T1D) is characterized by the immune-mediated destruction of insulin-producing islet β cells. Biomarkers capable of identifying T1D risk and dissecting disease-related heterogeneity represent an unmet clinical need.
Evans-Molina, Carmella +4 more
core +2 more sources
Placental-mediated increased cytokine response to lipopolysaccharides: a potential mechanism for enhanced inflammation susceptibility of the preterm fetus. [PDF]
, 2012 BackgroundCerebral palsy is a nonprogressive motor impairment syndrome that has no effective cure. The etiology of most cases of cerebral palsy remains unknown; however, recent epidemiologic data have demonstrated an association between fetal neurologic ...
Belkacemi, Louiza +4 more
core +1 more source
Frontiers in Immunology, 2019 SATB1 is a genome organizer protein that is expressed in a lineage specific manner in CD4+ T-cells. SATB1 plays a crucial role in expression of multiple genes throughout the thymic development and peripheral differentiation of T cells.
Satyajeet P. Khare +10 more
doaj +1 more source
T-Cell activation: a queuing theory analysis at low agonist density [PDF]
, 2006 We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Wedagedera, J. R., Burroughs, Nigel John
core +1 more source
Impact of dietary manganese on intestinal barrier and inflammatory response in broilers challenged with Salmonella Typhimurium [PDF]
, 2020 Growing concern for public health and food safety has prompted a special interest in developing nutritional strategies for removing waterborne and foodborne pathogens, including Salmonella.
Bai, Jie +11 more
core +2 more sources
Cytokine Signaling in Tumor Progression [PDF]
Immune Network, 2017 Cytokines are molecules that play critical roles in the regulation of a wide range of normal functions leading to cellular proliferation, differentiation and survival, as well as in specialized cellular functions enabling host resistance to pathogens.
Lee, Myungmi, Rhee, Inmoo
openaire +2 more sources
Torsional stability of interference screws derived from bovine bone - a biomechanical study [PDF]
, 2010 Introduction: It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its signaling system showed an ...
Joscha Bauer +66 more
core +1 more source
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
eLife, 2019 Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes.
Jonathan Martinez-Fabregas +12 more
doaj +1 more source
Global landscape of mouse and human cytokine transcriptional regulation [PDF]
, 2018 Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that recruit ...
Fuxman Bass, Juan Ignacio +8 more
core +1 more source
A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies. [PDF]
PLoS ONE, 2016 Enhancement or inhibition of cytokine signaling and corresponding immune cells responses are critical factors in various disease treatments. Cytokine signaling may be inhibited by cytokine-neutralizing antibodies (CNAs), which prevents further activation
Boris Shulgin +2 more
doaj +1 more source