Results 31 to 40 of about 1,666,972 (256)

3’UTR of SARS-CoV-2 spike gene hijack host miR-296 or miR-520h to disturb cell proliferation and cytokine signaling

Frontiers in Immunology, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has becoming globally public health threat. Recently studies were focus on SARS-CoV-2 RNA to design vaccine and drugs.
Jinjin Yuan, Ziheng Feng, Qiaowen Wang, Lifen Han, Shenchan Guan, Lijuan Liu, Hanhui Ye, Lili Xu, Xiao Han, Xiao Han   +9 more
doaj   +1 more source

Retrovirus Entry by Endocytosis and Cathepsin Proteases

Advances in Virology, 2012
Retroviruses include infectious agents inducing severe diseases in humans and animals. In addition, retroviruses are widely used as tools to transfer genes of interest to target cells.
Yoshinao Kubo, Hideki Hayashi, Toshifumi Matsuyama, Hironori Sato, Naoki Yamamoto   +4 more
doaj   +1 more source

Antioxidant Effects of PS5, a Peptidomimetic of Suppressor of Cytokine Signaling 1, in Experimental Atherosclerosis

Antioxidants, 2020
The chronic activation of the Janus kinase/signal transducer and activator of the transcription (JAK/STAT) pathway is linked to oxidative stress, inflammation and cell proliferation.
Sara La Manna, Laura Lopez-Sanz, Susana Bernal, Luna Jimenez-Castilla, Ignacio Prieto, Giancarlo Morelli, Carmen Gomez-Guerrero, Daniela Marasco   +7 more
doaj   +1 more source

Dysregulated peripheral proteome reveals NASH-specific signatures identifying patient subgroups with distinct liver biology

Frontiers in Immunology, 2023
Background and aimsNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. The prognosis may vary from simple steatosis to more severe outcomes such as nonalcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular ...
Natalie Stiglund, Hannes Hagström, Hannes Hagström, Per Stål, Per Stål, Martin Cornillet, Niklas K. Björkström   +6 more
doaj   +1 more source

Transcriptional responses of tumor cell lines to interferon-alpha [PDF]

, 2013
Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core   +1 more source

Structure-Activity Relationship Investigations of Novel Constrained Chimeric Peptidomimetics of SOCS3 Protein Targeting JAK2

Pharmaceuticals, 2022
SOCS3 (suppressor of cytokine signaling 3) protein suppresses cytokine-induced inflammation and its deletion in neurons or immune cells increases the pathological growth of blood vessels. Recently, we designed several SOCS3 peptidomimetics by assuming as
Sara La Manna, Marilisa Leone, Flavia Anna Mercurio, Daniele Florio, Daniela Marasco   +4 more
doaj   +1 more source

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells [PDF]

, 2012
This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/3.0/). Copyright @ 2012 Elsevier Inc.Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However,
Miao, T, Bhullar, P, Liu, M, Wang, P, Sebastian, M, Ghaffari, E, Li, S, Symonds, ALJ   +7 more
core   +1 more source

PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling

Frontiers in Immunology, 2020
Arginine methylation is a post-translational modification that regulates many biological processes. However, the role of arginine methylation in immune cells is not well studied.
Yukinori Tanaka, Yasuhiro Nagai, Mariko Okumura, Mark I. Greene, Taku Kambayashi   +4 more
doaj   +1 more source

SOCS1 (suppressor of cytokine signaling 1) [PDF]

, 2008
Review on SOCS1 (suppressor of cytokine signaling 1), with data on DNA, on the protein encoded, and where the gene is ...
Lin, LI, Tien, HF
core   +1 more source

Acute cytokine treatment stimulates glucose uptake and glycolysis in human keratinocytes

, 2023
During inflammation, cellular glucose uptake and glycolysis are upregulated to meet an increased energy demand. For example, keratinocyte glycolysis is essential for progression of psoriasis.
Holt, Vance, Colbert, Robert A., Morén, Björn, Fryklund, Claes, Stenkula, Karin G., Morén, Björn,, Stenkula, Karin G.,, Fryklund, Claes,, Colbert, Robert A.,, Lund University., Holt, Vance,   +10 more
core   +2 more sources