Results 11 to 20 of about 772,973 (298)
Socs3b regulates the development and function of innate immune cells in zebrafish
Frontiers in Immunology, 2023 IntroductionSuppressor of cytokine signaling 3 (SOCS3) is a critical component of the negative feedback regulation that controls signaling by cytokines and other factors thereby ensuring that important processes such as hematopoiesis and inflammation ...
Mohamed L. Sobah +7 more
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Cytokine tuning of intestinal epithelial function [PDF]
, 2018 The intestine serves as both our largest single barrier to the external environment and the host of more immune cells than any other location in our bodies.
Andrews, Caroline +2 more
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Editorial: Cytokine signaling and innate host defense in modulation of viral infections and the viral evasion [PDF]
Frontiers in Cellular and Infection MicrobiologyM. Victoria Delpino, Jorge Quarleri
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Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain
Pharmaceuticals, 2023 Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical and ...
Anniina T. Virtanen +8 more
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Hematopoietic cytokine receptor signaling [PDF]
Oncogene, 2007 Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Proper culmination of these diverse pathways forms the basis for an orderly generation of different cell types. Recent studies conducted over the past 10-15 years have revealed that hematopoietic cytokine receptor ...
S J, Baker, S G, Rane, E P, Reddy
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Biotechnology & Biotechnological Equipment, 2021 Bone loss is caused by inflammation and is mediated by pro-inflammatory cytokines that control bone formation and bone resorption. The study aimed to determine the effect of secreted factors from human bone marrow-derived stromal cells (hBMSC) of no ...
Amer Mahmood* +3 more
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Frontiers in Immunology, 2023 AimsExpanded hemodialysis (HDx) therapy with improved molecular cut-off dialyzers exerts beneficial effects on lowering uremia-associated chronic systemic microinflammation, a driver of endothelial dysfunction and cardiovascular disease (CVD) in ...
Hongfan Zhao +15 more
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Cytokine Signaling Exposed [PDF]
Structure, 2011 In this issue, Lupardus et al. (2011) provide images, obtained by electron microscopy, of a complete cytokine signaling complex, offering clues into the mechanism by which binding of cytokines to their cognate receptors triggers trans-phosphorylation and activation of Janus kinases.
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Cells, 2022 Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses.
Devasahayam Arokia Balaya Rex +7 more
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Influence of lipopolysaccharide on proinflammatory gene expression in human corneal, conjunctival and meibomian gland epithelial cells [PDF]
, 2018 PURPOSE: Lipopolysaccharide (LPS), a bacterial endotoxin, is known to stimulate leuokotriene B4 (LTB4) secretion by human corneal (HCECs), conjunctival (HConjECs) and meibomian gland (HMGECs) epithelial cells.
Chen, Di +5 more
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