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Cytokine Storm Syndromes in Pediatric Patients

The Journal of Allergy and Clinical Immunology: In Practice, 2023
Cytokine storm syndromes (CSS) represent a diverse group of disorders characterized by severe overactivation of the immune system. In the majority of patients, CSS arise from a combination of host factors, including genetic risk and predisposing conditions, and acute triggers such as infections.
Caroline Diorio, David T. Teachey, Scott W. Canna   +2 more
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Bacteria-Associated Cytokine Storm Syndrome

2019
While viruses are considered the most common infectious triggers for cytokine storm syndromes (CSS), a growing list of bacterial pathogens, particularly intracellular organisms, have been frequently reported to be associated with this syndrome. Both familial and sporadic cases of CSS are often precipitated by acute infections.
Esraa M, Eloseily, Randy Q, Cron
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Criteria for Cytokine Storm Syndromes

In the past two decades, there has been a great deal of work aimed to devise diagnostic guidelines, classification criteria, and diagnostic scores for cytokine storm syndromes (CSSs). The most notable effort has been the large-scale multinational study that led to the development of the 2016 classification criteria for macrophage activation syndrome ...
Francesca, Minoia, Angelo, Ravelli
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Cytokine Storm of Acute Necrotizing Encephalopathy

Pediatric Neurology, 2011
Acute necrotizing encephalopathy is a rare, clinically distinct entity characterized by multiple, symmetric areas of edema and necrosis in the thalamus, cerebellum, brainstem, and white matter. It is postulated to arise from uncontrolled cytokine release during a febrile illness, and is most often seen in East Asia.
Sujay M, Kansagra, William B, Gallentine
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Predicting cytokine storms: it's about density

Blood, 2011
Romer and colleagues in this issue of Blood report that the density of T cells during culture increases sensitivity to the CD28 cosignaling agent TGN1412, providing an improved means of predicting cytokine release syndrome (CRS).[1][1] CRS is a common clinical event with antibody therapies such ...
Matthew J, Frigault, Carl H, June
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Calming the cytokine storm

Science, 2015
Lung Disease The innate immune response is poised to act quickly in the face of pathogenic invaders. However, this priming can incite a cytokine storm: excessive production of inflammatory cytokines that harm the host. Coon et al. now report that HECTD2, a ubiquitin E3 ligase, can degrade the anti-inflammatory protein PIAS1, enhancing this inflammatory
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Autoinflammatory Contributors to Cytokine Storm

Cytokine Storm is a complex and heterogeneous state of life-threatening systemic inflammation and immunopathology. Autoinflammation is a mechanistic category of immune dysregulation wherein immunopathology originates due to poor regulation of innate immunity.
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Cytokine Storms

Infectious Diseases in Clinical Practice, 2010
Allison Nazinitsky, Kenneth S. Rosenthal
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Kawasaki Disease-Associated Cytokine Storm Syndrome

Kawasaki disease (KD) is a hyperinflammatory syndrome manifesting as an acute systemic vasculitis characterized by fever, nonsuppurative conjunctival injection, rash, oral mucositis, extremity changes, and cervical lymphadenopathy. KD predominantly affects young children and shares clinical features and immunobiology with other hyperinflammation ...
Paul, Tsoukas, Rae S M, Yeung
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The signal pathways and treatment of cytokine storm in COVID-19

Signal Transduction and Targeted Therapy, 2021
Jinrong Fu, Damo Xu, Yufeng zhou
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