Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
New statistical method identifes cytokines that distinguish stool microbiomes [PDF]
, 2019 Regressing an outcome or dependent variable onto a set of input or independent variables allows the analyst to measure associations between the two so that changes in the outcome can be described by and predicted by changes in the inputs. While there are
Deych, Elena +8 more
core +2 more sources
IFN-gamma is associated with risk of Schistosoma japonicum infection in China.
, 2003 Before the start of the schistosomiasis transmission season, 129 villagers resident on a Schistosoma japonicum-endemic island in Poyang Lake, Jiangxi Province, 64 of whom were stool-positive for S.
Bickle, QD +13 more
core +1 more source
Cytokines as cellular communicators
Mediators of Inflammation, 1996 Cytokines and their receptors are involved in the pathophysiology of many diseases. Here we present a detailed review on cytokines, receptors and signalling routes, and show that one important lesson from cytokine biology is the complex and diverse ...
R. Debets, H. F. J. Savelkoul
doaj +1 more source
IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis. [PDF]
, 1989 George B. Zavoico +3 more
openalex +1 more source
Molecular Oncology, Volume 19, Issue 5, Page 1291-1294, May 2025.Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger +2 more
wiley +1 more source
Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not β2-microglobulin in human synovial cells and fibroblasts [PDF]
, 1989 E.E. Golds, Patrizia Mason, P Nyirkos
openalex +1 more source
MIF as an oncogenic driver of low‐heterogeneity melanomas
Molecular Oncology, Volume 19, Issue 5, Page 1295-1298, May 2025.Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran +4 more
wiley +1 more source
Canadian Journal of Gastroenterology, 2001 Cytokines are pleiotropic peptides produced by virtually every nucleated cell in the body. In most tissues, including the liver, constitutive production of cytokines is absent or minimal.
Herbert Tilg
doaj +1 more source
Human endothelial cells prolong eosinophil survival. Regulation by cytokines and glucocorticoids. [PDF]
, 1989 Ana Lamas +2 more
openalex +1 more source