Results 1 to 10 of about 26,177 (142)

In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection [PDF]

BMC Immunology, 2011
Background Leishmania parasites have been reported to interfere and even subvert their host immune responses to enhance their chances of survival and proliferation.
Pereira Bernardo AS, Silva Franklin S, Rebello Karina M, Marín-Villa Marcel, Traub-Cseko Yara M, Andrade Thereza CB, Bertho Álvaro L, Caffarena Ernesto R, Alves Carlos R   +8 more
doaj   +3 more sources

Bidirectional cytokine-microRNA control: A novel immunoregulatory framework in leishmaniasis

PLoS Pathogens, 2022
As effector innate immune cells and as a host to the protozoan parasite Leishmania, macrophages play a dual role in antileishmanial immunoregulation.
Abdollah Jafarzadeh, Maryam Nemati, Najmeh Aminizadeh, Neelam Bodhale, Arup Sarkar, Sara Jafarzadeh, Iraj Sharifi, Bhaskar Saha   +7 more
doaj   +3 more sources

New Therapeutic Tools to Shape Monocyte Functional Phenotypes in Leishmaniasis

Frontiers in Immunology, 2021
In the innate immunity to Leishmania infection tissue-resident macrophages and inflammatory monocytes accumulate host-cell, effector, and efferocytosis functions.
Natália S. Vellozo, Thaís S. Rigoni, Marcela F. Lopes   +2 more
doaj   +1 more source

CD300a Receptor Blocking Enhances Early Clearance of Leishmania donovani From Its Mammalian Host Through Modulation of Effector Functions of Phagocytic and Antigen Experienced T Cells

Frontiers in Immunology, 2022
The parasites of the genus Leishmania survive and proliferate in the host phagocytic cells by taking control over their microbicidal functions. The parasite also promotes differentiation of antigen-specific anti-inflammatory cytokines producing effector ...
Rajan Singh, Anshul Anand, Arun K. Rawat, Shashi Saini, Baishakhi Mahapatra, Naveen K. Singh, Alok K. Mishra, Samer Singh, Nisha Singh, Dhiraj Kishore, Vinod Kumar, Pradeep Das, Rakesh K. Singh   +12 more
doaj   +1 more source

MHC class II restricted innate-like double negative T cells contribute to optimal primary and secondary immunity to Leishmania major. [PDF]

PLoS Pathogens, 2014
Although it is generally believed that CD4(+) T cells play important roles in anti-Leishmania immunity, some studies suggest that they may be dispensable, and that MHC II-restricted CD3(+)CD4(-)CD8(-) (double negative, DN) T cells may be more important ...
Zhirong Mou, Dong Liu, Ifeoma Okwor, Ping Jia, Kanami Orihara, Jude Ezeh Uzonna   +5 more
doaj   +1 more source

Transcription of toll-like receptors 2, 3, 4 and 9, FoxP3 and Th17 cytokines in a susceptible experimental model of canine Leishmania infantum infection [PDF]

, 2015
Canine leishmaniosis (CanL) due to Leishmania infantum is a chronic zoonotic systemic disease resulting from complex interactions between protozoa and the canine immune system.
A Ives, A Rodriguez, A Rodriguez-Cortes, A Rodriguez-Cortes, A Rodriguez-Cortes, AB Reis, AK House, AK Rai, Alhelí Rodríguez-Cortés, AM Elassad, BL Travi, C Gallego, C Gonzalez-Lombana, C Maia, C Maia, C Riera, CE O'Neil, CF Alves, CR Engwerda, D Menezes-Souza, D Sacks, D Strauss-Ayali, DA Vargas-Inchaustegui, Damer P. Blake, E Bourreau, F Chappuis, FF Tuon, FF Tuon, G Baneth, GA Cezario, GD Melo, GK Katara, GM Santos-Gomes, H Kumar, IR Peters, J Alvar, J Liese, J Moreno, J Sano, JF Flandin, JM Ehrchen, Jordi Alberola, K Ghosh, K Wolk, Karin Allenspach, KL Silva, L Solano-Gallego, L Solano-Gallego, Laia Solano-Gallego, LM Melo, LP Carvalho, MA Almeida, MG Pitta, MJ de Veer, MJ Rica-Capela, MM Figueiredo, MM Figueiredo, MS Nascimento, N Peters, O Courtenay, O Francino, OA Garden, OR Rodrigues, P Desjeux, P Holzmuller, P Kropf, R Kumar, S Lopez Kostka, S Nylen, S Schmitz, S Tiwananthagorn, S Tolouei, SH Wood, Shazia Hosein, T Korn, TM Castilho, VL da Matta, VS Boaventura, VS Raman, Y Belkaid, Yara M. Traub-Csekö, ZK Peng   +81 more
core   +12 more sources

The Comparison of the IFN-ɤ, TNF-α and IL-10 Cytokines in Healing and Non-healing Cutaneous Leishmaniasis

Iranian Journal of Parasitology, 2021
Background: Leishmaniasis is one of the main vectors borne and neglected tropical parasitic diseases. T cell cytokine responses are highly important in the presentations of disease such as control or progression, and understanding of the host ...
Mina Taraghian, Helena Hanif, Parisa Mousavi, Zahra Baharlooeyan cheshmeh, Azam Samei, Abbas Abdollahi, Hossein Vazini   +6 more
doaj   +1 more source

Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected by Leishmania major and Leishmania amazonensis: The Use of Gene Regulatory Networks in Modeling This Pathway

Frontiers in Cellular and Infection Microbiology, 2022
Leishmania amazonensis and Leishmania major are the causative agents of cutaneous and mucocutaneous diseases. The infections‘ outcome depends on host–parasite interactions and Th1/Th2 response, and in cutaneous form, regulation of Th17 cytokines has been
Leilane Oliveira Gonçalves, Leilane Oliveira Gonçalves, Andrés F. Vallejo Pulido, Fernando Augusto Siqueira Mathias, Alexandre Estevão Silvério Enes, Alexandre Estevão Silvério Enes, Maria Gabriela Reis Carvalho, Daniela de Melo Resende, Marta E. Polak, Jeronimo C. Ruiz   +9 more
doaj   +1 more source

Parasitology [PDF]

, 2005
Concomitant infections are common in nature and often involve parasites. A number of examples of the interactions between protozoa and viruses, protozoa and bacteria, protozoa and other protozoa, protozoa and helminths, helminths and viruses, helminths ...
Cox, F, Despommier, D, Gillespie, S, Wakelin, D   +3 more
core   +5 more sources

Cytokine profile in Leishmania-positive blood donors.

PLoS ONE, 2020
Serum levels of interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 17 (IL-17), interferon gamma (IFN-γ), tumor necrosis factor α (TNF-α), and interleukin 1β (IL-1β), cytokines involved in the immune ...
Adriana de Oliveira França, Luana Silva Soares, Mauricio Antonio Pompilio, Inês Aparecida Tozetti, Camila Mareti Bonin, Maria Elizabeth Moraes Cavalheiros Dorval   +5 more
doaj   +1 more source