Results 181 to 190 of about 26,266 (223)

Role of host genetics and cytokines in Leishmania infection

Cytokine, 2021
Cytokines and chemokines are important regulators of innate and specific responses in leishmaniasis, a disease that currently affects 12 million people. We overviewed the current information about influences of genetically engineered mouse models of cytokine and chemokine on leishmaniasis.
Imtissal, Krayem, Marie, Lipoldová
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Cytokines and metabolic regulation: A framework of bidirectional influences affecting Leishmania infection

Cytokine, 2021
Leishmania, a protozoan parasite inflicting the complex of diseases called Leishmaniases, resides and replicates as amastigotes within mammalian macrophages. As macrophages are metabolically highly active and can generate free radicals that can destroy this parasite, Leishmania also devise strategies to modulate the host cell metabolism.
Neelam Bodhale, Mareike Ohms, Carolina Ferreira, Inês Mesquita, Arkajyoti Mukherjee, Sónia André, Arup Sarkar, Jérôme Estaquier, Tamás Laskay, Bhaskar Saha, Ricardo Silvestre   +10 more
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Metabolic regulation of cytokine production in leishmania resistance and susceptibility

The Journal of Immunology, 2020
Abstract Leishmania, a protozoan parasite, ensures its survival inside its mammalian host by modulating host metabolism and immune response. Recent advances in the field of immune-metabolism have shown that the metabolic enzymes and metabolites have immune-modulatory functions.
Neelam Prakash Bodhale, Arup Sarkar, Debprasad Chattopadhyay, Bhaskar Saha, Maitree Bhattacharyya   +4 more
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Role of pro-inflammatory cytokine IL-17 in Leishmania pathogenesis and in protective immunity by Leishmania vaccines

Cellular Immunology, 2016
The clinical outcome of Leishmania pathogenesis ranges from active skin lesions to fatal visceral dissemination and severely impaired T cell immunity. It is well established that a strong Th1 immune response is protective against cutaneous forms of the disease, however a mixed Th1/Th2 response is most commonly observed against visceral infections as ...
Antara, Banerjee, Parna, Bhattacharya, Amritanshu B, Joshi, Nevien, Ismail, Ranadhir, Dey, Hira L, Nakhasi   +5 more
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Leishmania DNA load and cytokine expression levels in asymptomatic naturally infected dogs

Veterinary Parasitology, 2006
The factors responsible for the clinical progress of visceral leishmaniasis (VL) in dogs have not been yet established. The starting hypothesis was the possibility of associating the changing level of a specific type of cytokines with the evolution of the infection towards infection-manifested disease or resistant behaviour.
Laura, Manna, Stefano, Reale, Elisabetta, Viola, Fabrizio, Vitale, Valentina, Foglia Manzillo, Luigi Michele, Pavone, Pavone Luigi, Michele, Santo, Caracappa, Angelo Elio, Gravino   +8 more
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P010 Cytokine milieu and nitrite release during early challenge of human PBMC by Leishmania infantum and Leishmania major

Cytokine, 2012
Introduction Although Th1/Th2 paradigma may account for experimental Leishmaniasis pathogenesis in animals, data on cellular immunity mediators in early phase of human Leishmania infections are still limited and controversial. Therefore the aim of this study was to investigate some Th1 and Th2 cytokines, MCP-1, among the monocyte chemokines, and ...
G. Matera, A. Quirino, L. Rametti, M. Arvaniti, M.C. Liberto, A. Focà   +5 more
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Cytokine profile and nitric oxide levels in macrophages exposed to Leishmania infantum FML

Experimental Parasitology, 2019
Fucose-mannose ligand (FML) is a soluble antigen purified from Leishmania donovani complex and used for diagnosis, prognosis, and vaccine development against visceral leishmaniasis (VL). We aimed to explore the effects of FML on the production of cytokines, chemokines and nitric oxide (NO) by macrophages in vitro.
Shafiei Reza, Namdar Ahmadabad Hasan, Nezafat Firizi Maryam, BakhshiJoibari Fahimeh, Amirali Ghahremani, Hatam GholamReza, Ghatee Mohammad Amin   +6 more
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Monocyte cytokine and costimulatory molecule expression in patients infected with Leishmania mexicana

Parasite Immunology, 2006
SUMMARYLeishmania mexicana causes localized and diffuse cutaneous leishmaniasis. Patients with localized cutaneous leishmaniasis (LCL) develop a benign disease, whereas patients with diffuse cutaneous leishmaniasis (DCL) suffer from a progressive disease associated with anergy of the cellular response towards Leishmania antigens.
G, Carrada, C, Cañeda, N, Salaiza, J, Delgado, A, Ruiz, B, Sanchez, L, Gutiérrez-Kobeh, M, Aguirre, I, Becker   +8 more
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Effect of Leishmania RNA virus 2 on virulence factors and cytokines gene expression in a human macrophage infected with Leishmania major: A preliminary study

Experimental Parasitology, 2023
Cutaneous leishmaniasis (CL) is one of the most important infectious parasitic diseases in the world caused by the Leishmania parasite. In recent decades, the presence of a virus from the Totiviridae family has been proven in some Leishmania species.
Milad, Rahmanipour, Mehdi, Mohebali, Mona, Koosha, Elham, Kazemirad, Setayesh, Yasami-Khiabani, Hamed, Mirjalali, Homa, Hajjaran   +6 more
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Enhanced production of pro-inflammatory cytokines and chemokines in Ethiopian cutaneous leishmaniasis upon exposure to Leishmania aethiopica

Cytokine, 2021
The clinical course and outcome of cutaneous leishmaniasis (CL) vary due to the infecting Leishmania species and host genetic makeup that result in different immune responses against the parasites. The host immune response to Leishmania aethiopica (L.aethiopica), the causative agent of CL in Ethiopia, is poorly understood.
Menberework Chanyalew, Markos Abebe, Birtukan Endale, Selfu Girma, Geremew Tasew, Ger van Zandbergen, Uwe Ritter, Endalamaw Gadisa, Abraham Aseffa, Tamás Laskay   +9 more
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