Results 11 to 20 of about 26,266 (223)

Infection of Human Neutrophils With Leishmania infantum or Leishmania major Strains Triggers Activation and Differential Cytokines Release [PDF]

Frontiers in Cellular and Infection Microbiology, 2019
Leishmaniases are neglected diseases, caused by intracellular protozoan parasites of the Leishmania (L.) genus. Although the principal host cells of the parasites are macrophages, neutrophils are the first cells rapidly recruited to the site of parasites
Rafeh Oualha, Rafeh Oualha, Mourad Barhoumi, Soumaya Marzouki, Emna Harigua-Souiai, Melika Ben Ahmed, Ikram Guizani   +6 more
doaj   +4 more sources

Aspidosperma nitidum reduces parasite load and modulates cytokines in BALB/c mice infected with Leishmania (Leishmania) amazonensis

Frontiers in Chemistry
The lack of vaccines shows the need for alternative leishmaniasis treatments. In vitro study previously demonstrated the leishmanicidal activity of A. nitidum extracts. This study describes for the first time, the antileishmanial activity of A.
Heliton Patrick Cordovil Brígido, Heliton Patrick Cordovil Brígido, Everton Luiz Pompeu Varela, Everton Luiz Pompeu Varela, Antônio Rafael Quadros Gomes, Antônio Rafael Quadros Gomes, Antônio Rafael Quadros Gomes, Antônio Rafael Quadros Gomes, Jorddy Neves Cruz, Juliana Correa-Barbosa, José Edson de Sousa Siqueira, Cristian Kallahan Silva Chagas, Andrey Moacir do Rosário Marinho, Liliane Almeida Carneiro, Márlia Regina Coelho-Ferreira, Sandro Percário, Sandro Percário, Maria Fâni Dolabela, Maria Fâni Dolabela, Maria Fâni Dolabela   +19 more
doaj   +3 more sources

Role of Host and Parasite MIF Cytokines during Leishmania Infection. [PDF]

Trop Med Infect Dis, 2020
Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine that has been extensively characterized in human disease and in mouse models. Its pro-inflammatory functions in mammals includes the retention of tissue macrophages and a unique ability to counteract the immunosuppressive activity of glucocorticoids.
Holowka T, Bucala R.
europepmc   +5 more sources

Lipophosphoglycan From Dermotropic New World Leishmania Upregulates Interleukin-32 and Proinflammatory Cytokines Through TLR4 and NOD2 Receptors

Frontiers in Cellular and Infection Microbiology, 2022
Interleukin-32 (IL-32) is produced during Leishmania infection, but the components of the parasite that induce its production are unknown. An important multivirulence factor of Leishmania spp.
Murilo Barros Silveira, Rodrigo Saar Gomes, Marina Tiemi Shio, Jeronimo Nunes Rugani, Larissa Ferreira Paranaiba, Rodrigo Pedro Soares, Fátima Ribeiro-Dias   +6 more
doaj   +3 more sources

Cortisol Regulates PD-1 and IL-12 in Canine Leishmaniasis. [PDF]

Parasite Immunol
ABSTRACT Canine visceral leishmaniasis (CanL) is a tropical zoonosis caused by Brazil's protozoan Leishmania (L.) infantum. Disorders in the hypothalamic–pituitary–adrenal (HPA) axis have been reported in human and experimental visceral leishmaniasis, but not yet in canine leishmaniasis.
Ito LTS, Umino GM, Guimarães MA, de Souza BMM, Soares SF, Pereira LEAL, de Lima VMF.   +6 more
europepmc   +2 more sources

The cytokine/chemokine response in Leishmania/HIV infection and co-infection

Heliyon, 2023
HIV infection progressively weakens the immune system by infecting and destroying cells involved in host defense. Viral infection symptoms are generated and aggravated as immunosuppression progresses, triggered by the presence of opportunistic infections: among these is leishmaniasis, a disease caused by the intracellular parasite Leishmania.
Semer Maksoud, Joelle El Hokayem
openaire   +3 more sources

Cytokine and Phenotypic Cell Profiles ofLeishmania infantumInfection in the Dog [PDF]

Journal of Tropical Medicine, 2012
Leishmaniasis has reemerged in recent years showing a wider geographic distribution and increased global incidence of human and canine disease than previously known. Dogs are the main domestic/peridomestic reservoir hosts of zoonotic visceral leishmaniasis caused byLeishmania infantum.
Carla Maia, Lenea Campino
openaire   +4 more sources

Cytokines and splenic remodelling during Leishmania donovani infection

Cytokine: X, 2020
Visceral leishmaniasis (VL) causes extensive splenic pathology that contributes to dysfunctional immune responses, in part through displacement and destruction of cell populations involved in maintaining splenic structural integrity. The expression of pro and anti-inflammatory cytokines and chemokines is crucial in orchestrating the delicate balance ...
Montes de Oca, Marcela, Engwerda, Christian R, Kaye, Paul M   +2 more
openaire   +4 more sources

Cytokine and phenotypic cell profiles in human cutaneous leishmaniasis caused byLeishmania donovani

PLOS ONE, 2022
AbstractBackgroundThe innate immune mediators are likely to influence the clinical phenotype of leishmaniasis by primary responses which limit or facilitate the spread of the parasite, as well as by modulating adaptive immunity. This study investigated the response of key innate immune cells in a focus which regularly reports localised cutaneous ...
Hiruni Wijesooriya, Nilakshi Samaranayake, Nadira D. Karunaweera   +2 more
openaire   +4 more sources

Suppression of LPS-induced inflammatory responses in macrophages infected with Leishmania

Journal of Inflammation, 2010
Background Chronic inflammation activated by macrophage innate pathogen recognition receptors such as TLR4 can lead to a range of inflammatory diseases, including atherosclerosis, Crohn's disease, arthritis and cancer.
Kelly Ben L, Lapara Nicholas J
doaj   +1 more source