Results 191 to 200 of about 26,266 (223)

Leishmania major: Low infection dose causes short-lived hyperalgesia and cytokines upregulation in mice

Experimental Parasitology, 2006
Neural involvement was traditionally associated with leprosy. However, more recent studies have shown the presence of a persistent hyperalgesia in cutaneous leishmaniasis caused by the infection of BALB/c mice with a high dose of Leishmania major. In this study, we report the presence of hyperalgesia within the first two weeks of infection caused by a ...
Karam, MC, Hamdan, HG, Abi Chedid, NA, Baroody, GM, Bodman-Smith, KB, Eales-Reynolds, L-JE   +5 more
openaire   +3 more sources

Chlorogenic acid acts upon Leishmania donovani arresting cell cycle and modulating cytokines and nitric oxide in vitro

Parasite Immunology, 2020
AbstractAimsVisceral leishmaniasis (VL), caused by Leishmania donovani in India, is fatal if untreated, having serious concern of limited chemotherapeutic options. In this study, we evaluated antileishmanial efficacy of purified chlorogenic acid (CGA) against promastigotes and intracellular amastigotes infected into RAW264.7 macrophages.Methods and ...
Nilanjana Majumder, Subhrajit Ganguly, Arijit Kumar Ghosh, Shreetoma Kundu, Antara Banerjee, Samiran Saha   +5 more
openaire   +2 more sources

Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex

Journal of Neuroimmunology, 2016
Neurological symptoms have been associated with Leishmania infection, however little is known about how the nervous system is affected in leishmaniasis. This work aimed to analyze parasitic load, production of cytokines/neurotrophins in the prefrontal cortex and behavioral changes in BALB/c mice infected with Leishmania amazonensis.
Alex, Portes, Elizabeth, Giestal-de-Araujo, Aline, Fagundes, Pablo, Pandolfo, Arnaldo, de Sá Geraldo, Marie Luce Flores, Lira, Veronica Figueiredo, Amaral, Jussara, Lagrota-Candido   +7 more
openaire   +2 more sources

Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells

Acta Tropica, 2006
Specific immune responses by CD4+ and CD8+ T cells, from two infected mice strains (BALB/c and C57BL/6), induced by High, Inter and Low protein fractions released by Leishmania infantum, were assessed through the evaluation of IL-12, IFN-gamma and IL-10 mRNA by real-time PCR and respective protein production by ELISA.
Ricardo, Rosa, Cláudia, Marques, Olivia Roos, Rodrigues, Gabriela M, Santos-Gomes   +3 more
openaire   +2 more sources

CD40 signaling induces reciprocal outcomes in Leishmania-infected macrophages; roles of host genotype and cytokine milieu

Microbes and Infection, 2005
We investigated the influence of CD40-CD40 ligand-mediated signaling on induction of microbicidal activity against Leishmania major in macrophages from resistant (B6) and susceptible (BALB) mouse strains. CD40 engagement induced leishmanicidal activity in resistant macrophages, but increased parasite replication in susceptible macrophages.
Marise P, Nunes, Lea, Cysne-Finkelstein, Bruna C, Monteiro, Daniel M, de Souza, Nitza A, Gomes, George A, DosReis   +5 more
openaire   +2 more sources

[Leishmania-macrophage interactions: role of cytokines and molecules co-involved in killing].

Parassitologia, 1996
In this review we have summarized the main data concerning Leishmania-macrophage interactions, with particular emphasis on receptors involved in adhesion, activating or deactivating cytokines and toxic molecules responsible for parasite killing. At present it is also known that a different T helper (Th)1- or Th2-cell response may be critical for the ...
S M, Faliero, R, Marzio, M A, Panaro, O, Brandonisio   +3 more
openaire   +1 more source

Nitric oxide production by Leishmania-infected macrophages and modulation by cytokines and prostaglandins.

Parassitologia, 2002
Nitric oxide (NO) produced by an inducible nitric oxide synthase (iNOS or NOS2) plays a major microbicidal role in murine macrophages and its importance is now emerging also in the dog and human models. In dogs we demonstrated that macrophages in vitro infected with Leishmania infantum produced NO, after stimulation with cytokine-enriched peripheral ...
BRANDONISIO O., ACQUAFREDDA A., LEOGRANDE D., MITOLO V., PANARO, Maria Antonietta, SISTO, MARGHERITA, FUMAROLA, Luciana   +6 more
openaire   +1 more source

In situ cytokines (IL-4, IL-10, IL-12, IFN-γ) and chemokines (MCP-1, MIP-1α) gene expression in human Leishmania (Leishmania) mexicana infection

Cytokine, 2014
Crucial to the defense against Leishmania is the ability of the host to mount a cell-mediated immune response capable of controlling and/or eliminating the parasite. The composition of the cell populations recruited in the early phase of the infection seems to be essential for defining the infection outcomes.
Guillermo, Valencia-Pacheco, Elsy Nalleli, Loría-Cervera, Erika Ivett, Sosa-Bibiano, Elsy B, Canché-Pool, Alberto, Vargas-Gonzalez, Peter C, Melby, Fernando J, Andrade-Narvaez   +6 more
openaire   +2 more sources

Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model.

European cytokine network, 1999
The murine Leishmania major model has proven fertile ground for the elucidation of CD4+ T cell effector subset differentiation in vivo. The availability of a highly susceptible inbred strain, BALB/c, that develops progressive disease due to the aberrant differentiation of Th2, as opposed to protective Th1, responses, has allowed the identification of ...
D J, Fowell, M, Bix, K, Shinkai, D, Lacy, R M, Locksley   +4 more
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
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